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Polysaccharides in Fungi. XXXIV. A polysaccharide from the fruiting bodies of Amanita muscaria and the antitumor activity of its carboxymethylated product.
Biol Pharm Bull. 1994 Nov; 17(11):1460-2.BP

Abstract

A water-insoluble, alkali-soluble, glucan (AM-APP), [alpha]D +160 degrees in 0.4 M NaOH, was isolated from the alkaline extract of the fruiting bodies of Amanita muscaria. The results of chemical and spectroscopic investigations indicate that AM-APP is a linear (1 --> 3)-alpha-D-glucan with a molecular weigh estimated by gel chromatography of about 42000. Its carboxymethylated product (AM-APP-CM) showed potent antitumor activity against sarcoma 180 in mice, although the native polysaccharide (AM-APP) had little effect. The distribution of carboxymethyl groups in the molecule was analyzed by gas chromatography and mass spectrometry. The degree of substitution of carboxymethyl groups was 0.95 and the substituents were located at O-2, at O-4, at O-6, at O-2 and O-6, and at O-4 and O-6 on glucose.

Authors+Show Affiliations

Gifu Pharmaceutical University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

7703963

Citation

Kiho, T, et al. "Polysaccharides in Fungi. XXXIV. a Polysaccharide From the Fruiting Bodies of Amanita Muscaria and the Antitumor Activity of Its Carboxymethylated Product." Biological & Pharmaceutical Bulletin, vol. 17, no. 11, 1994, pp. 1460-2.
Kiho T, Yoshida I, Katsuragawa M, et al. Polysaccharides in Fungi. XXXIV. A polysaccharide from the fruiting bodies of Amanita muscaria and the antitumor activity of its carboxymethylated product. Biol Pharm Bull. 1994;17(11):1460-2.
Kiho, T., Yoshida, I., Katsuragawa, M., Sakushima, M., Usui, S., & Ukai, S. (1994). Polysaccharides in Fungi. XXXIV. A polysaccharide from the fruiting bodies of Amanita muscaria and the antitumor activity of its carboxymethylated product. Biological & Pharmaceutical Bulletin, 17(11), 1460-2.
Kiho T, et al. Polysaccharides in Fungi. XXXIV. a Polysaccharide From the Fruiting Bodies of Amanita Muscaria and the Antitumor Activity of Its Carboxymethylated Product. Biol Pharm Bull. 1994;17(11):1460-2. PubMed PMID: 7703963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polysaccharides in Fungi. XXXIV. A polysaccharide from the fruiting bodies of Amanita muscaria and the antitumor activity of its carboxymethylated product. AU - Kiho,T, AU - Yoshida,I, AU - Katsuragawa,M, AU - Sakushima,M, AU - Usui,S, AU - Ukai,S, PY - 1994/11/1/pubmed PY - 1994/11/1/medline PY - 1994/11/1/entrez SP - 1460 EP - 2 JF - Biological & pharmaceutical bulletin JO - Biol Pharm Bull VL - 17 IS - 11 N2 - A water-insoluble, alkali-soluble, glucan (AM-APP), [alpha]D +160 degrees in 0.4 M NaOH, was isolated from the alkaline extract of the fruiting bodies of Amanita muscaria. The results of chemical and spectroscopic investigations indicate that AM-APP is a linear (1 --> 3)-alpha-D-glucan with a molecular weigh estimated by gel chromatography of about 42000. Its carboxymethylated product (AM-APP-CM) showed potent antitumor activity against sarcoma 180 in mice, although the native polysaccharide (AM-APP) had little effect. The distribution of carboxymethyl groups in the molecule was analyzed by gas chromatography and mass spectrometry. The degree of substitution of carboxymethyl groups was 0.95 and the substituents were located at O-2, at O-4, at O-6, at O-2 and O-6, and at O-4 and O-6 on glucose. SN - 0918-6158 UR - https://www.unboundmedicine.com/medline/citation/7703963/Polysaccharides_in_Fungi__XXXIV__A_polysaccharide_from_the_fruiting_bodies_of_Amanita_muscaria_and_the_antitumor_activity_of_its_carboxymethylated_product_ DB - PRIME DP - Unbound Medicine ER -