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Abortion and the risk of breast cancer: a case-control study in Greece.

Abstract

We have examined the association between induced or spontaneous abortion and breast cancer risk in Greece. In a hospital-based case-control study in Athens, 820 patients with confirmed breast cancer were compared with 795 orthopedic patient controls and 753 healthy visitor controls, matched to cases by age and interviewer. Logistic regression was used to analyze the data, controlling for demographic, reproductive and nutritional variables. Odds ratio (OR) patterns were similar for the 2 control series, which were therefore combined to increase precision of the estimates. The risk for breast cancer was not increased for women who had a history of abortion, compared to nulliparous women with no history of abortion. Thus ORs and 95% confidence intervals were for nulliparous women with spontaneous abortion, 1.17 (0.64-2.13); for nulliparous women with induced abortion, 0.98 (0.56-1.73); for parous women with no abortion, 0.56 (0.31-1.01); for parous women with spontaneous abortion, 0.61 (0.33-1.14) and for parous women with induced abortion, 0.99 (0.56-1.74). When the analysis was restricted to parous women, using parous women with no history of abortion as the baseline, ORs and 95% confidence intervals were for induced abortion before first full-term pregnancy, 2.06 (1.45-2.90); for induced abortion after first full-term pregnancy, 1.59 (1.24-2.04) and for spontaneous abortion, 1.10 (0.82-1.40). Our findings suggest that an interrupted pregnancy does not impart the long-term protective effect of a full-term pregnancy attributable to terminal differentiation.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.

    , , ,

    Source

    International journal of cancer 61:2 1995 Apr 10 pg 181-4

    MeSH

    Abortion, Induced
    Abortion, Spontaneous
    Adult
    Breast Neoplasms
    Case-Control Studies
    Female
    Greece
    Humans
    Parity
    Pregnancy
    Risk Factors

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    7705945

    Citation

    Lipworth, L, et al. "Abortion and the Risk of Breast Cancer: a Case-control Study in Greece." International Journal of Cancer, vol. 61, no. 2, 1995, pp. 181-4.
    Lipworth L, Katsouyanni K, Ekbom A, et al. Abortion and the risk of breast cancer: a case-control study in Greece. Int J Cancer. 1995;61(2):181-4.
    Lipworth, L., Katsouyanni, K., Ekbom, A., Michels, K. B., & Trichopoulos, D. (1995). Abortion and the risk of breast cancer: a case-control study in Greece. International Journal of Cancer, 61(2), pp. 181-4.
    Lipworth L, et al. Abortion and the Risk of Breast Cancer: a Case-control Study in Greece. Int J Cancer. 1995 Apr 10;61(2):181-4. PubMed PMID: 7705945.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Abortion and the risk of breast cancer: a case-control study in Greece. AU - Lipworth,L, AU - Katsouyanni,K, AU - Ekbom,A, AU - Michels,K B, AU - Trichopoulos,D, PY - 1995/4/10/pubmed PY - 1995/4/10/medline PY - 1995/4/10/entrez KW - Abortion, Induced KW - Abortion, Spontaneous KW - Biology KW - Breast Cancer KW - Cancer KW - Case Control Studies KW - Correlation Studies KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Europe KW - Family Planning KW - Fertility KW - Fertility Control, Postconception KW - Fertility Measurements KW - Greece KW - Mediterranean Countries KW - Neoplasms KW - Parity KW - Population KW - Population Dynamics KW - Pregnancy Complications KW - Research Methodology KW - Risk Factors KW - Southern Europe KW - Statistical Studies KW - Studies SP - 181 EP - 4 JF - International journal of cancer JO - Int. J. Cancer VL - 61 IS - 2 N2 - We have examined the association between induced or spontaneous abortion and breast cancer risk in Greece. In a hospital-based case-control study in Athens, 820 patients with confirmed breast cancer were compared with 795 orthopedic patient controls and 753 healthy visitor controls, matched to cases by age and interviewer. Logistic regression was used to analyze the data, controlling for demographic, reproductive and nutritional variables. Odds ratio (OR) patterns were similar for the 2 control series, which were therefore combined to increase precision of the estimates. The risk for breast cancer was not increased for women who had a history of abortion, compared to nulliparous women with no history of abortion. Thus ORs and 95% confidence intervals were for nulliparous women with spontaneous abortion, 1.17 (0.64-2.13); for nulliparous women with induced abortion, 0.98 (0.56-1.73); for parous women with no abortion, 0.56 (0.31-1.01); for parous women with spontaneous abortion, 0.61 (0.33-1.14) and for parous women with induced abortion, 0.99 (0.56-1.74). When the analysis was restricted to parous women, using parous women with no history of abortion as the baseline, ORs and 95% confidence intervals were for induced abortion before first full-term pregnancy, 2.06 (1.45-2.90); for induced abortion after first full-term pregnancy, 1.59 (1.24-2.04) and for spontaneous abortion, 1.10 (0.82-1.40). Our findings suggest that an interrupted pregnancy does not impart the long-term protective effect of a full-term pregnancy attributable to terminal differentiation. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/7705945/Abortion_and_the_risk_of_breast_cancer:_a_case_control_study_in_Greece_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0020-7136&date=1995&volume=61&issue=2&spage=181 DB - PRIME DP - Unbound Medicine ER -