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No association between serum ferritin and asymptomatic carotid atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study.

Abstract

A possible association between body iron stores, measured as serum ferritin, and carotid arterial intima-media thickening was investigated in the Atherosclerosis Risk in Communities Study during 1990-1992 using a matched case-control design. For a 143-micrograms/liter greater serum ferritin concentration (the interquartile range), the odds ratio for cases with carotid intima-media thickening versus controls was 1.12 (95% confidence interval 0.97-1.30). However, there was no association (odds ratio = 1.00) after adjusting for major cardiovascular risk factors. This analysis of carotid arterial intima-media thickening, a measure of early atherosclerosis, in relation to serum ferritin does not support the hypothesis that increased body iron stores increase the risk of atherosclerotic cardiovascular disease.

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  • Authors+Show Affiliations

    ,

    Mayo Graduate School of Medicine, Rochester, MN, USA.

    , ,

    Source

    American journal of epidemiology 141:8 1995 Apr 15 pg 719-23

    MeSH

    Arteriosclerosis
    Carotid Artery Diseases
    Case-Control Studies
    Diet
    Female
    Ferritins
    Humans
    Iron
    Male
    Middle Aged
    Odds Ratio
    Risk Factors
    Tunica Intima
    Tunica Media

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    7709914

    Citation

    Moore, M, et al. "No Association Between Serum Ferritin and Asymptomatic Carotid Atherosclerosis. the Atherosclerosis Risk in Communities (ARIC) Study." American Journal of Epidemiology, vol. 141, no. 8, 1995, pp. 719-23.
    Moore M, Folsom AR, Barnes RW, et al. No association between serum ferritin and asymptomatic carotid atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study. Am J Epidemiol. 1995;141(8):719-23.
    Moore, M., Folsom, A. R., Barnes, R. W., & Eckfeldt, J. H. (1995). No association between serum ferritin and asymptomatic carotid atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study. American Journal of Epidemiology, 141(8), pp. 719-23.
    Moore M, et al. No Association Between Serum Ferritin and Asymptomatic Carotid Atherosclerosis. the Atherosclerosis Risk in Communities (ARIC) Study. Am J Epidemiol. 1995 Apr 15;141(8):719-23. PubMed PMID: 7709914.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - No association between serum ferritin and asymptomatic carotid atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study. AU - Moore,M, AU - Folsom,A R, AU - Barnes,R W, AU - Eckfeldt,J H, PY - 1995/4/15/pubmed PY - 1995/4/15/medline PY - 1995/4/15/entrez SP - 719 EP - 23 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 141 IS - 8 N2 - A possible association between body iron stores, measured as serum ferritin, and carotid arterial intima-media thickening was investigated in the Atherosclerosis Risk in Communities Study during 1990-1992 using a matched case-control design. For a 143-micrograms/liter greater serum ferritin concentration (the interquartile range), the odds ratio for cases with carotid intima-media thickening versus controls was 1.12 (95% confidence interval 0.97-1.30). However, there was no association (odds ratio = 1.00) after adjusting for major cardiovascular risk factors. This analysis of carotid arterial intima-media thickening, a measure of early atherosclerosis, in relation to serum ferritin does not support the hypothesis that increased body iron stores increase the risk of atherosclerotic cardiovascular disease. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/7709914/No_association_between_serum_ferritin_and_asymptomatic_carotid_atherosclerosis__The_Atherosclerosis_Risk_in_Communities__ARIC__Study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/oxfordjournals.aje.a117493 DB - PRIME DP - Unbound Medicine ER -