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Atrial natriuretic peptide response to postural change and medication in familial dysautonomia.
Clin Auton Res. 1994 Dec; 4(6):311-8.CA

Abstract

Circulating atrial natriuretic peptide (ANP) was assayed before and after postural change and exercise in 54 patients with familial dysautonomia (FD) and 20 controls. ANP levels were compared with blood pressure, heart rate, plasma catecholamines and parameters of renal function. Compared with controls supine FD subjects had elevated blood pressures, heart rates and ANP levels (39 +/- 4 pg/ml vs. 23 +/- 3 pg/ml, p < 0.01). With the erect posture and exercise in FD subjects, blood pressure fell below control values, with ANP lowered. In FD subjects, blood pressure was correlated with ANP levels when supine and when erect and with heart rate post exercise. In controls, ANP levels did not correlate with other parameters. In FD patients on metoclopramide, supine and erect blood pressure and ANP levels were higher. FD subjects treated with fludrocortisone, had elevated supine and erect noradrenaline (p < 0.05 and p = 0.06); and those on diazepam had lower erect and post exercise noradrenaline (p < 0.05), but ANP levels were similar. In conclusion, sympathetic denervation may increase FD patients' responsiveness to other regulators of cardiovascular integrity, such as ANP. In addition, circulating ANP and catecholamines in FD subjects appear to be influenced by commonly used medications, such as metoclopramide.

Authors+Show Affiliations

Department of Pediatrics, New York University Medical Center, NY 10016, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7711467

Citation

Axelrod, F B., et al. "Atrial Natriuretic Peptide Response to Postural Change and Medication in Familial Dysautonomia." Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society, vol. 4, no. 6, 1994, pp. 311-8.
Axelrod FB, Krey L, Glickstein JS, et al. Atrial natriuretic peptide response to postural change and medication in familial dysautonomia. Clin Auton Res. 1994;4(6):311-8.
Axelrod, F. B., Krey, L., Glickstein, J. S., Friedman, D., Weider, J., Metakis, L. J., Porges, V. M., Mineo, M., & Notterman, D. (1994). Atrial natriuretic peptide response to postural change and medication in familial dysautonomia. Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society, 4(6), 311-8.
Axelrod FB, et al. Atrial Natriuretic Peptide Response to Postural Change and Medication in Familial Dysautonomia. Clin Auton Res. 1994;4(6):311-8. PubMed PMID: 7711467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atrial natriuretic peptide response to postural change and medication in familial dysautonomia. AU - Axelrod,F B, AU - Krey,L, AU - Glickstein,J S, AU - Friedman,D, AU - Weider,J, AU - Metakis,L J, AU - Porges,V M, AU - Mineo,M, AU - Notterman,D, PY - 1994/12/1/pubmed PY - 1994/12/1/medline PY - 1994/12/1/entrez SP - 311 EP - 8 JF - Clinical autonomic research : official journal of the Clinical Autonomic Research Society JO - Clin Auton Res VL - 4 IS - 6 N2 - Circulating atrial natriuretic peptide (ANP) was assayed before and after postural change and exercise in 54 patients with familial dysautonomia (FD) and 20 controls. ANP levels were compared with blood pressure, heart rate, plasma catecholamines and parameters of renal function. Compared with controls supine FD subjects had elevated blood pressures, heart rates and ANP levels (39 +/- 4 pg/ml vs. 23 +/- 3 pg/ml, p < 0.01). With the erect posture and exercise in FD subjects, blood pressure fell below control values, with ANP lowered. In FD subjects, blood pressure was correlated with ANP levels when supine and when erect and with heart rate post exercise. In controls, ANP levels did not correlate with other parameters. In FD patients on metoclopramide, supine and erect blood pressure and ANP levels were higher. FD subjects treated with fludrocortisone, had elevated supine and erect noradrenaline (p < 0.05 and p = 0.06); and those on diazepam had lower erect and post exercise noradrenaline (p < 0.05), but ANP levels were similar. In conclusion, sympathetic denervation may increase FD patients' responsiveness to other regulators of cardiovascular integrity, such as ANP. In addition, circulating ANP and catecholamines in FD subjects appear to be influenced by commonly used medications, such as metoclopramide. SN - 0959-9851 UR - https://www.unboundmedicine.com/medline/citation/7711467/Atrial_natriuretic_peptide_response_to_postural_change_and_medication_in_familial_dysautonomia_ L2 - http://www.diseaseinfosearch.org/result/3379 DB - PRIME DP - Unbound Medicine ER -