Tags

Type your tag names separated by a space and hit enter

The mechanism of histamine release induced by the ionophore X537A from isolated rat mast cells. I. Significance of monovalent cations, calcium, metabolic energy and temperature.
Acta Physiol Scand. 1978 Mar; 102(3):265-73.AP

Abstract

Histamine release induced by X537A from isolated rat mast cells was dependent on the presence of sodium or potassium but not on calcium in the incubation medium. The rate of release was faster in potassium than in sodium, but the final release was the same after prolonged incubation. Extracellular calcium as well as metabolic inhibitors depressed the rate or release induced by X537A. Pretreatment of mast cells with either EDTA or the ionophore A23187 in the absence of extracellular calcium did not influence subsequent release induced by X537A. The findings of release at 45 degrees C and lack of release at 0 degrees C distinguish the mechanism of action of X537A from calcium- energy-dependent releasing agents like compound 48/80 and A23187 on the one hand and the simple lytic action of decylamine on the other.

Authors

Kazimierczak W
No affiliation info available
Patkar SA
No affiliation info available
Diamant B
No affiliation info available

MeSH

AnimalsAnti-Bacterial AgentsCalcimycinCalciumCells, CulturedCulture MediaEdetic AcidFemaleHistamine ReleaseLasalocidMaleMast CellsPotassiumRatsSodiumTemperaturep-Methoxy-N-methylphenethylamine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

77122

Citation

Kazimierczak, W, et al. "The Mechanism of Histamine Release Induced By the Ionophore X537A From Isolated Rat Mast Cells. I. Significance of Monovalent Cations, Calcium, Metabolic Energy and Temperature." Acta Physiologica Scandinavica, vol. 102, no. 3, 1978, pp. 265-73.
Kazimierczak W, Patkar SA, Diamant B. The mechanism of histamine release induced by the ionophore X537A from isolated rat mast cells. I. Significance of monovalent cations, calcium, metabolic energy and temperature. Acta Physiol Scand. 1978;102(3):265-73.
Kazimierczak, W., Patkar, S. A., & Diamant, B. (1978). The mechanism of histamine release induced by the ionophore X537A from isolated rat mast cells. I. Significance of monovalent cations, calcium, metabolic energy and temperature. Acta Physiologica Scandinavica, 102(3), 265-73.
Kazimierczak W, Patkar SA, Diamant B. The Mechanism of Histamine Release Induced By the Ionophore X537A From Isolated Rat Mast Cells. I. Significance of Monovalent Cations, Calcium, Metabolic Energy and Temperature. Acta Physiol Scand. 1978;102(3):265-73. PubMed PMID: 77122.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The mechanism of histamine release induced by the ionophore X537A from isolated rat mast cells. I. Significance of monovalent cations, calcium, metabolic energy and temperature. AU - Kazimierczak,W, AU - Patkar,S A, AU - Diamant,B, PY - 1978/3/1/pubmed PY - 1978/3/1/medline PY - 1978/3/1/entrez SP - 265 EP - 73 JF - Acta physiologica Scandinavica JO - Acta Physiol Scand VL - 102 IS - 3 N2 - Histamine release induced by X537A from isolated rat mast cells was dependent on the presence of sodium or potassium but not on calcium in the incubation medium. The rate of release was faster in potassium than in sodium, but the final release was the same after prolonged incubation. Extracellular calcium as well as metabolic inhibitors depressed the rate or release induced by X537A. Pretreatment of mast cells with either EDTA or the ionophore A23187 in the absence of extracellular calcium did not influence subsequent release induced by X537A. The findings of release at 45 degrees C and lack of release at 0 degrees C distinguish the mechanism of action of X537A from calcium- energy-dependent releasing agents like compound 48/80 and A23187 on the one hand and the simple lytic action of decylamine on the other. SN - 0001-6772 UR - https://www.unboundmedicine.com/medline/citation/77122/The_mechanism_of_histamine_release_induced_by_the_ionophore_X537A_from_isolated_rat_mast_cells__I__Significance_of_monovalent_cations_calcium_metabolic_energy_and_temperature_ L2 - https://doi.org/10.1111/j.1748-1716.1978.tb06073.x DB - PRIME DP - Unbound Medicine ER -