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Effect of oral isotretinoin treatment on skin androgen receptor levels in male acneic patients.
J Clin Endocrinol Metab. 1995 Apr; 80(4):1158-61.JC

Abstract

An oral daily dose (mean +/- SD, 0.75 +/- 0.05 mg/kg) of isotretinoin was administered for 3 months to six male patients with acne (scores of 4 and 5 according to Rosenfield). The therapy resulted in complete resolution of acne in four patients and improved acne significantly (score 1) in two patients. In accordance with recent findings, no change in serum testosterone and significant decreases in 5 alpha-dihydrotestosterone, 5 alpha-androstane-3 alpha,17 beta-diol glucosiduronate, and androsterone glucosiduronate levels were observed after treatment. Androgen receptor status was investigated in back skin biopsies obtained in acne areas before and after 3 months of isotretinoin treatment. The treatment did not modify the binding affinity constant of skin androgen receptor (0.44 vs. 0.32 nmol/L), but it did induce a 2.6-fold decrease in its binding capacity constant (62 vs. 24 fmol/mg cytosolic protein), as assessed by Scatchard plot and confirmed immunologically by Western blot analysis. These data clearly showed that skin androgen receptor was sensitive to oral isotretinoin administration in acneic patients. The decrease in skin androgen receptor levels (this study) and the recently reported suppression of skin 5 alpha-dihydrotestosterone production by isotretinoin treatment appeared consistent with the involvement of androgen receptor and 5 alpha-dihydrotestosterone in the pathogenesis of acne. Indeed, sebum production is under androgen control, and an abnormal response of the pilosebaceous unit to androgens appears to be implicated in the pathogenesis of acne. These observations were consistent with the absence of sebum in complete androgen-insensitive patients and normal sebum production in male pseudohermaphrodites.

Authors+Show Affiliations

Department of Hormonal Biology, St. Louis University Hospital, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

7714084

Citation

Boudou, P, et al. "Effect of Oral Isotretinoin Treatment On Skin Androgen Receptor Levels in Male Acneic Patients." The Journal of Clinical Endocrinology and Metabolism, vol. 80, no. 4, 1995, pp. 1158-61.
Boudou P, Soliman H, Chivot M, et al. Effect of oral isotretinoin treatment on skin androgen receptor levels in male acneic patients. J Clin Endocrinol Metab. 1995;80(4):1158-61.
Boudou, P., Soliman, H., Chivot, M., Villette, J. M., Vexiau, P., Belanger, A., & Fiet, J. (1995). Effect of oral isotretinoin treatment on skin androgen receptor levels in male acneic patients. The Journal of Clinical Endocrinology and Metabolism, 80(4), 1158-61.
Boudou P, et al. Effect of Oral Isotretinoin Treatment On Skin Androgen Receptor Levels in Male Acneic Patients. J Clin Endocrinol Metab. 1995;80(4):1158-61. PubMed PMID: 7714084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of oral isotretinoin treatment on skin androgen receptor levels in male acneic patients. AU - Boudou,P, AU - Soliman,H, AU - Chivot,M, AU - Villette,J M, AU - Vexiau,P, AU - Belanger,A, AU - Fiet,J, PY - 1995/4/1/pubmed PY - 1995/4/1/medline PY - 1995/4/1/entrez SP - 1158 EP - 61 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 80 IS - 4 N2 - An oral daily dose (mean +/- SD, 0.75 +/- 0.05 mg/kg) of isotretinoin was administered for 3 months to six male patients with acne (scores of 4 and 5 according to Rosenfield). The therapy resulted in complete resolution of acne in four patients and improved acne significantly (score 1) in two patients. In accordance with recent findings, no change in serum testosterone and significant decreases in 5 alpha-dihydrotestosterone, 5 alpha-androstane-3 alpha,17 beta-diol glucosiduronate, and androsterone glucosiduronate levels were observed after treatment. Androgen receptor status was investigated in back skin biopsies obtained in acne areas before and after 3 months of isotretinoin treatment. The treatment did not modify the binding affinity constant of skin androgen receptor (0.44 vs. 0.32 nmol/L), but it did induce a 2.6-fold decrease in its binding capacity constant (62 vs. 24 fmol/mg cytosolic protein), as assessed by Scatchard plot and confirmed immunologically by Western blot analysis. These data clearly showed that skin androgen receptor was sensitive to oral isotretinoin administration in acneic patients. The decrease in skin androgen receptor levels (this study) and the recently reported suppression of skin 5 alpha-dihydrotestosterone production by isotretinoin treatment appeared consistent with the involvement of androgen receptor and 5 alpha-dihydrotestosterone in the pathogenesis of acne. Indeed, sebum production is under androgen control, and an abnormal response of the pilosebaceous unit to androgens appears to be implicated in the pathogenesis of acne. These observations were consistent with the absence of sebum in complete androgen-insensitive patients and normal sebum production in male pseudohermaphrodites. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/7714084/Effect_of_oral_isotretinoin_treatment_on_skin_androgen_receptor_levels_in_male_acneic_patients_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem.80.4.7714084 DB - PRIME DP - Unbound Medicine ER -