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Changes in mood during acute hypoglycemia in healthy participants.

Abstract

Acute hypoglycemia provides a reproducible method of investigating the effect of biological changes induced during hypoglycemia on mood states. Hypoglycemia was induced twice using a hyperinsulinemic glucose clamp in 24 nondiabetic human participants; a euglycemic placebo control study was also performed. Serial changes in mood were assessed using the UWIST Mood Adjective Checklist before, during, and after 60 min of controlled hypoglycemia (2.5 mmol/l). Hypoglycemia induced a significant reduction in hedonic tone (p = .001), a significant increase in tense arousal (p < .0005), and a significant decline in energetic arousal (p = .01) in comparison with the euglycemia control study. Profound changes in mood were observed in nondiabetic participants during acute hypoglycemia, and a state called tense tiredness persisted for at least 30 min after restoration of euglycemia.

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  • Authors+Show Affiliations

    ,

    Department of Diabetes, Royal Infirmary of Edinburgh, Scotland.

    , ,

    Source

    MeSH

    Adult
    Affect
    Arousal
    Blood Glucose
    Female
    Humans
    Hyperinsulinism
    Hypoglycemia
    Male
    Personality Inventory

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    7714726

    Citation

    Gold, A E., et al. "Changes in Mood During Acute Hypoglycemia in Healthy Participants." Journal of Personality and Social Psychology, vol. 68, no. 3, 1995, pp. 498-504.
    Gold AE, MacLeod KM, Frier BM, et al. Changes in mood during acute hypoglycemia in healthy participants. J Pers Soc Psychol. 1995;68(3):498-504.
    Gold, A. E., MacLeod, K. M., Frier, B. M., & Deary, I. J. (1995). Changes in mood during acute hypoglycemia in healthy participants. Journal of Personality and Social Psychology, 68(3), pp. 498-504.
    Gold AE, et al. Changes in Mood During Acute Hypoglycemia in Healthy Participants. J Pers Soc Psychol. 1995;68(3):498-504. PubMed PMID: 7714726.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Changes in mood during acute hypoglycemia in healthy participants. AU - Gold,A E, AU - MacLeod,K M, AU - Frier,B M, AU - Deary,I J, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 498 EP - 504 JF - Journal of personality and social psychology JO - J Pers Soc Psychol VL - 68 IS - 3 N2 - Acute hypoglycemia provides a reproducible method of investigating the effect of biological changes induced during hypoglycemia on mood states. Hypoglycemia was induced twice using a hyperinsulinemic glucose clamp in 24 nondiabetic human participants; a euglycemic placebo control study was also performed. Serial changes in mood were assessed using the UWIST Mood Adjective Checklist before, during, and after 60 min of controlled hypoglycemia (2.5 mmol/l). Hypoglycemia induced a significant reduction in hedonic tone (p = .001), a significant increase in tense arousal (p < .0005), and a significant decline in energetic arousal (p = .01) in comparison with the euglycemia control study. Profound changes in mood were observed in nondiabetic participants during acute hypoglycemia, and a state called tense tiredness persisted for at least 30 min after restoration of euglycemia. SN - 0022-3514 UR - https://www.unboundmedicine.com/medline/citation/7714726/Changes_in_mood_during_acute_hypoglycemia_in_healthy_participants_ L2 - http://content.apa.org/journals/psp/68/3/498 DB - PRIME DP - Unbound Medicine ER -