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Effects of testosterone on triglyceride uptake and mobilization in different adipose tissues in male rats in vivo.
Obes Res. 1995 Mar; 3(2):113-9.OR

Abstract

The effects of testosterone (T) on uptake and mobilization of orally administered triglyceride were examined in male rats. In order to attempt to explain regional differences, adipose tissue metabolism was studied in vivo. (U-14 C) oleic acid in sesame oil was given by gastric gavage to male, sham operated, castrated and castrated + T substituted rats, and accumulation and half-life of radioactivity measured. In castrated rats in comparisons with sham-operated and castrated + T rats, serum T was absent, and body weight lower (p < 0.05 or 0.01), but adipocytes in retroperitoneal and mesenteric tissues became significantly heavier. Radioactivity (dpm/mg triglyceride) was higher, in retroperitoneal tissue at 4 hours, 7, 30 days, and in mesenteric tissue at 4 hours, and at 30 and 60 days after oral label administration (0.1 > p > 0.05 or p < 0.05), no differences were seen in epididymal or inguinal depots at 4 hours. When radioactivity was expressed per adipocyte, the castrated group showed significantly higher radioactivity when compared to sham and castrated + T groups at 7 and 30 days in retroperitoneal and at 60 days in mesenteric adipocytes (p < 0.05 or 0.01). Half life (T 1/2) of radioactivity was longer in mesenteric tissue in the castrated rats than the other two groups (sham group, 33 days +/- 2; castrated group, 58 days +/- 6; and castrated + T group, 39 days +/- 3, p < 0.05), but there were no differences between groups in retroperitoneal adipose tissue.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Wallenberg Laboratory, Sahlgren's Hospital, University of Göteborg, Sweden.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7719957

Citation

Li, M, and P Björntorp. "Effects of Testosterone On Triglyceride Uptake and Mobilization in Different Adipose Tissues in Male Rats in Vivo." Obesity Research, vol. 3, no. 2, 1995, pp. 113-9.
Li M, Björntorp P. Effects of testosterone on triglyceride uptake and mobilization in different adipose tissues in male rats in vivo. Obes Res. 1995;3(2):113-9.
Li, M., & Björntorp, P. (1995). Effects of testosterone on triglyceride uptake and mobilization in different adipose tissues in male rats in vivo. Obesity Research, 3(2), 113-9.
Li M, Björntorp P. Effects of Testosterone On Triglyceride Uptake and Mobilization in Different Adipose Tissues in Male Rats in Vivo. Obes Res. 1995;3(2):113-9. PubMed PMID: 7719957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of testosterone on triglyceride uptake and mobilization in different adipose tissues in male rats in vivo. AU - Li,M, AU - Björntorp,P, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 113 EP - 9 JF - Obesity research JO - Obes. Res. VL - 3 IS - 2 N2 - The effects of testosterone (T) on uptake and mobilization of orally administered triglyceride were examined in male rats. In order to attempt to explain regional differences, adipose tissue metabolism was studied in vivo. (U-14 C) oleic acid in sesame oil was given by gastric gavage to male, sham operated, castrated and castrated + T substituted rats, and accumulation and half-life of radioactivity measured. In castrated rats in comparisons with sham-operated and castrated + T rats, serum T was absent, and body weight lower (p < 0.05 or 0.01), but adipocytes in retroperitoneal and mesenteric tissues became significantly heavier. Radioactivity (dpm/mg triglyceride) was higher, in retroperitoneal tissue at 4 hours, 7, 30 days, and in mesenteric tissue at 4 hours, and at 30 and 60 days after oral label administration (0.1 > p > 0.05 or p < 0.05), no differences were seen in epididymal or inguinal depots at 4 hours. When radioactivity was expressed per adipocyte, the castrated group showed significantly higher radioactivity when compared to sham and castrated + T groups at 7 and 30 days in retroperitoneal and at 60 days in mesenteric adipocytes (p < 0.05 or 0.01). Half life (T 1/2) of radioactivity was longer in mesenteric tissue in the castrated rats than the other two groups (sham group, 33 days +/- 2; castrated group, 58 days +/- 6; and castrated + T group, 39 days +/- 3, p < 0.05), but there were no differences between groups in retroperitoneal adipose tissue.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/7719957/Effects_of_testosterone_on_triglyceride_uptake_and_mobilization_in_different_adipose_tissues_in_male_rats_in_vivo_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=1071-7323&amp;date=1995&amp;volume=3&amp;issue=2&amp;spage=113 DB - PRIME DP - Unbound Medicine ER -