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Effect of chronic treatment of adult spontaneously hypertensive rats with an endothelin receptor antagonist.
Hypertension. 1995 Apr; 25(4 Pt 1):495-500.H

Abstract

We previously showed that endothelin-1 expression was increased in vascular endothelium of deoxycorticosterone acetate-salt hypertensive rats, whereas in spontaneously hypertensive rats (SHR) it is similar to or less than that in normotensive rats. Treatment with the combined endothelin type A/endothelin type B receptor antagonist bosentan moderately reduced blood pressure rise and nearly completely blunted the development of vascular hypertrophy, particularly in small arteries, in the deoxycorticosterone acetate-salt hypertensive model, suggesting a paracrine role for vascular endothelin-1 in the induction of blood vessel hypertrophy in some forms of experimental hypertension. In the present study we examined the effect of chronic oral treatment for 4 weeks of 12-week-old SHR and Wistar-Kyoto rats (WKY) with 100 mg/kg per day bosentan. Blood pressure rose to hypertensive levels similarly in bosentan-treated and untreated SHR; systolic pressure of WKY was also unaffected. The wet weights of the heart, of aortic segments, and of the mesenteric arterial bed were similar in treated and untreated SHR. When coronary, renal arcuate, mesenteric, and femoral small arteries were evaluated on a wire myograph, the media width and media-to-lumen ratio were greater and the lumen diameter was smaller in vessels from SHR relative to those from WKY, except in small arteries from the renal cortex, in which the lumen was not significantly different in both strains. The media cross-sectional area of small arteries fom the four vascular beds was similar in both strains. Identical morphometric parameters were found in the four vascular beds in bosentan-treated and untreated rats of eh strain.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

MRC Multidisciplinary Research Group on Hypertension, University of Montréal, Quebec, Canada.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7721389

Citation

Li, J S., and E L. Schiffrin. "Effect of Chronic Treatment of Adult Spontaneously Hypertensive Rats With an Endothelin Receptor Antagonist." Hypertension (Dallas, Tex. : 1979), vol. 25, no. 4 Pt 1, 1995, pp. 495-500.
Li JS, Schiffrin EL. Effect of chronic treatment of adult spontaneously hypertensive rats with an endothelin receptor antagonist. Hypertension. 1995;25(4 Pt 1):495-500.
Li, J. S., & Schiffrin, E. L. (1995). Effect of chronic treatment of adult spontaneously hypertensive rats with an endothelin receptor antagonist. Hypertension (Dallas, Tex. : 1979), 25(4 Pt 1), 495-500.
Li JS, Schiffrin EL. Effect of Chronic Treatment of Adult Spontaneously Hypertensive Rats With an Endothelin Receptor Antagonist. Hypertension. 1995;25(4 Pt 1):495-500. PubMed PMID: 7721389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of chronic treatment of adult spontaneously hypertensive rats with an endothelin receptor antagonist. AU - Li,J S, AU - Schiffrin,E L, PY - 1995/4/1/pubmed PY - 1995/4/1/medline PY - 1995/4/1/entrez SP - 495 EP - 500 JF - Hypertension (Dallas, Tex. : 1979) JO - Hypertension VL - 25 IS - 4 Pt 1 N2 - We previously showed that endothelin-1 expression was increased in vascular endothelium of deoxycorticosterone acetate-salt hypertensive rats, whereas in spontaneously hypertensive rats (SHR) it is similar to or less than that in normotensive rats. Treatment with the combined endothelin type A/endothelin type B receptor antagonist bosentan moderately reduced blood pressure rise and nearly completely blunted the development of vascular hypertrophy, particularly in small arteries, in the deoxycorticosterone acetate-salt hypertensive model, suggesting a paracrine role for vascular endothelin-1 in the induction of blood vessel hypertrophy in some forms of experimental hypertension. In the present study we examined the effect of chronic oral treatment for 4 weeks of 12-week-old SHR and Wistar-Kyoto rats (WKY) with 100 mg/kg per day bosentan. Blood pressure rose to hypertensive levels similarly in bosentan-treated and untreated SHR; systolic pressure of WKY was also unaffected. The wet weights of the heart, of aortic segments, and of the mesenteric arterial bed were similar in treated and untreated SHR. When coronary, renal arcuate, mesenteric, and femoral small arteries were evaluated on a wire myograph, the media width and media-to-lumen ratio were greater and the lumen diameter was smaller in vessels from SHR relative to those from WKY, except in small arteries from the renal cortex, in which the lumen was not significantly different in both strains. The media cross-sectional area of small arteries fom the four vascular beds was similar in both strains. Identical morphometric parameters were found in the four vascular beds in bosentan-treated and untreated rats of eh strain.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0194-911X UR - https://www.unboundmedicine.com/medline/citation/7721389/Effect_of_chronic_treatment_of_adult_spontaneously_hypertensive_rats_with_an_endothelin_receptor_antagonist_ L2 - https://www.ahajournals.org/doi/10.1161/01.hyp.25.4.495?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -