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Diagnostic value of serum peptides of collagen synthesis and degradation in dialysis renal osteodystrophy.
Nephrol Dial Transplant. 1995; 10(1):52-8.ND

Abstract

The assay of serum peptides of bone collagen formation and degradation could potentially provide an indirect estimate of the rate of bone turnover. In our study we have measured serum levels of the carboxy-terminal propeptide of type I procollagen (PICP) as a marker of bone formation and serum levels of the pyridinoline cross-linked telopeptide domain of type I collagen (ICTP) as a marker of bone resorption in 53 patients (47.7 +/- 10 years, M +/- SD) on haemodialysis (for 9.5 +/- 3.8 years) and affected by renal osteodystrophy. Besides PICP and ICTP, patients were also sampled for serum intact and C-terminal PTH, osteocalcin (BGP) and alkaline phosphatase (AP). A transiliac bone biopsy for histomorphometry was also performed in all. As expected both PTH assays, BGP and AP, were correlated reciprocally and to histomorphometric parameters. As for serum levels of PICP, they were on average increased (268.5 +/- 104.9 ng/ml, M +/- SD) compared to normals (range 66-176), but not correlated to classical humoral markers of hyperparathyroidism (PTH and AP), with the exception of BGP (with a rather low r value: 0.365, P < 0.01), nor to histomorphometric indices of bone resorption and formation.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Mazzaferro S
Renal Pathophysiology and Hypertension Unit, 2nd Medical Clinic, Rome, Italy.
Pasquali M
No affiliation info available
Ballanti P
No affiliation info available
Bonucci E
No affiliation info available
Costantini S
No affiliation info available
Chicca S
No affiliation info available
De Meo S
No affiliation info available
Perruzza I
No affiliation info available
Sardella D
No affiliation info available
Taggi F
No affiliation info available

MeSH

Alkaline PhosphataseAmino AcidsBiomarkersBone ResorptionBone and BonesChronic Kidney Disease-Mineral and Bone DisorderCollagenFemaleHumansMaleMiddle AgedOsteocalcinParathyroid HormonePeptide FragmentsProcollagenRenal Dialysis

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7724029

Citation

Mazzaferro, S, et al. "Diagnostic Value of Serum Peptides of Collagen Synthesis and Degradation in Dialysis Renal Osteodystrophy." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 10, no. 1, 1995, pp. 52-8.
Mazzaferro S, Pasquali M, Ballanti P, et al. Diagnostic value of serum peptides of collagen synthesis and degradation in dialysis renal osteodystrophy. Nephrol Dial Transplant. 1995;10(1):52-8.
Mazzaferro, S., Pasquali, M., Ballanti, P., Bonucci, E., Costantini, S., Chicca, S., De Meo, S., Perruzza, I., Sardella, D., & Taggi, F. (1995). Diagnostic value of serum peptides of collagen synthesis and degradation in dialysis renal osteodystrophy. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 10(1), 52-8.
Mazzaferro S, et al. Diagnostic Value of Serum Peptides of Collagen Synthesis and Degradation in Dialysis Renal Osteodystrophy. Nephrol Dial Transplant. 1995;10(1):52-8. PubMed PMID: 7724029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic value of serum peptides of collagen synthesis and degradation in dialysis renal osteodystrophy. A1 - Mazzaferro,S, AU - Pasquali,M, AU - Ballanti,P, AU - Bonucci,E, AU - Costantini,S, AU - Chicca,S, AU - De Meo,S, AU - Perruzza,I, AU - Sardella,D, AU - Taggi,F, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 52 EP - 8 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol Dial Transplant VL - 10 IS - 1 N2 - The assay of serum peptides of bone collagen formation and degradation could potentially provide an indirect estimate of the rate of bone turnover. In our study we have measured serum levels of the carboxy-terminal propeptide of type I procollagen (PICP) as a marker of bone formation and serum levels of the pyridinoline cross-linked telopeptide domain of type I collagen (ICTP) as a marker of bone resorption in 53 patients (47.7 +/- 10 years, M +/- SD) on haemodialysis (for 9.5 +/- 3.8 years) and affected by renal osteodystrophy. Besides PICP and ICTP, patients were also sampled for serum intact and C-terminal PTH, osteocalcin (BGP) and alkaline phosphatase (AP). A transiliac bone biopsy for histomorphometry was also performed in all. As expected both PTH assays, BGP and AP, were correlated reciprocally and to histomorphometric parameters. As for serum levels of PICP, they were on average increased (268.5 +/- 104.9 ng/ml, M +/- SD) compared to normals (range 66-176), but not correlated to classical humoral markers of hyperparathyroidism (PTH and AP), with the exception of BGP (with a rather low r value: 0.365, P < 0.01), nor to histomorphometric indices of bone resorption and formation.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0931-0509 UR - https://www.unboundmedicine.com/medline/citation/7724029/Diagnostic_value_of_serum_peptides_of_collagen_synthesis_and_degradation_in_dialysis_renal_osteodystrophy_ L2 - http://www.diseaseinfosearch.org/result/6208 DB - PRIME DP - Unbound Medicine ER -