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Evolutionary importance for the membrane enhancement of the production of vitamin D3 in the skin of poikilothermic animals.
Proc Natl Acad Sci U S A. 1995 Apr 11; 92(8):3124-6.PN

Abstract

The photoproduction of vitamin D in the skin was essential for the evolutionary development of terrestrial vertebrates. During exposure to sunlight, previtamin D3 formed in the skin is isomerized to vitamin D3 (calciol) by a temperature-dependent process. Since early land vertebrates were poikilothermic, the relatively slow conversion of previtamin D3 to vitamin D3 at ambient temperature put them at serious risk for developing vitamin D deficiency, thus leading to a poorly mineralized skeleton that could have ultimately halted further evolutionary development of vertebrates on land. We evaluated the rate of isomerization of previtamin D3 to vitamin D3 in the skin of iguanas and found the isomerization rate was enhanced by 1100% and 1700% at 25 degrees C and 5 degrees C, respectively. It is likely that the membrane entrapment of previtamin D3 in its s-cis,s-cis conformation is responsible for the markedly enhanced conversion of previtamin D3 to vitamin D3. The membrane-enhanced production of vitamin D3 ensures the critical supply of vitamin D3 to poikilothermic animals such as iguanas.

Authors+Show Affiliations

Department of Medicine, Boston University Medical Center, MA 02118, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7724526

Citation

Holick, M F., et al. "Evolutionary Importance for the Membrane Enhancement of the Production of Vitamin D3 in the Skin of Poikilothermic Animals." Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 8, 1995, pp. 3124-6.
Holick MF, Tian XQ, Allen M. Evolutionary importance for the membrane enhancement of the production of vitamin D3 in the skin of poikilothermic animals. Proc Natl Acad Sci U S A. 1995;92(8):3124-6.
Holick, M. F., Tian, X. Q., & Allen, M. (1995). Evolutionary importance for the membrane enhancement of the production of vitamin D3 in the skin of poikilothermic animals. Proceedings of the National Academy of Sciences of the United States of America, 92(8), 3124-6.
Holick MF, Tian XQ, Allen M. Evolutionary Importance for the Membrane Enhancement of the Production of Vitamin D3 in the Skin of Poikilothermic Animals. Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3124-6. PubMed PMID: 7724526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evolutionary importance for the membrane enhancement of the production of vitamin D3 in the skin of poikilothermic animals. AU - Holick,M F, AU - Tian,X Q, AU - Allen,M, PY - 1995/4/11/pubmed PY - 1995/4/11/medline PY - 1995/4/11/entrez KW - Non-programmatic SP - 3124 EP - 6 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc Natl Acad Sci U S A VL - 92 IS - 8 N2 - The photoproduction of vitamin D in the skin was essential for the evolutionary development of terrestrial vertebrates. During exposure to sunlight, previtamin D3 formed in the skin is isomerized to vitamin D3 (calciol) by a temperature-dependent process. Since early land vertebrates were poikilothermic, the relatively slow conversion of previtamin D3 to vitamin D3 at ambient temperature put them at serious risk for developing vitamin D deficiency, thus leading to a poorly mineralized skeleton that could have ultimately halted further evolutionary development of vertebrates on land. We evaluated the rate of isomerization of previtamin D3 to vitamin D3 in the skin of iguanas and found the isomerization rate was enhanced by 1100% and 1700% at 25 degrees C and 5 degrees C, respectively. It is likely that the membrane entrapment of previtamin D3 in its s-cis,s-cis conformation is responsible for the markedly enhanced conversion of previtamin D3 to vitamin D3. The membrane-enhanced production of vitamin D3 ensures the critical supply of vitamin D3 to poikilothermic animals such as iguanas. SN - 0027-8424 UR - https://www.unboundmedicine.com/medline/citation/7724526/Evolutionary_importance_for_the_membrane_enhancement_of_the_production_of_vitamin_D3_in_the_skin_of_poikilothermic_animals_ L2 - http://www.pnas.org/cgi/pmidlookup?view=long&pmid=7724526 DB - PRIME DP - Unbound Medicine ER -