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Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS.
J Pain Symptom Manage. 1995 Feb; 10(2):89-97.JP

Abstract

The effects of dronabinol on appetite and weight were evaluated in 139 patients with AIDS-related anorexia and > or = 2.3 kg weight loss in a multi-institutional study. Patients were randomized to receive 2.5 mg dronabinol twice daily or placebo. Patients rated appetite, mood, and nausea by using a 100-mm visual analogue scale 3 days weekly. Efficacy was evaluable in 88 patients. Dronabinol was associated with increased appetite above baseline (38% vs 8% for placebo, P = 0.015), improvement in mood (10% vs -2%, P = 0.06), and decreased nausea (20% vs 7%; P = 0.05). Weight was stable in dronabinol patients, while placebo recipients had a mean loss of 0.4 kg (P = 0.14). Of the dronabinol patients, 22% gained > or = 2 kg, compared with 10.5% of placebo recipients (P = 0.11). Side effects were mostly mild to moderate in severity (euphoria, dizziness, thinking abnormalities); there was no difference in discontinued therapy between dronabinol (8.3%) and placebo (4.5%) recipients. Dronabinol was found to be safe and effective for anorexia associated with weight loss in patients with AIDS.

Authors+Show Affiliations

St. John's Hospital, Tulsa, Oklahoma, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7730690

Citation

Beal, J E., et al. "Dronabinol as a Treatment for Anorexia Associated With Weight Loss in Patients With AIDS." Journal of Pain and Symptom Management, vol. 10, no. 2, 1995, pp. 89-97.
Beal JE, Olson R, Laubenstein L, et al. Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS. J Pain Symptom Manage. 1995;10(2):89-97.
Beal, J. E., Olson, R., Laubenstein, L., Morales, J. O., Bellman, P., Yangco, B., Lefkowitz, L., Plasse, T. F., & Shepard, K. V. (1995). Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS. Journal of Pain and Symptom Management, 10(2), 89-97.
Beal JE, et al. Dronabinol as a Treatment for Anorexia Associated With Weight Loss in Patients With AIDS. J Pain Symptom Manage. 1995;10(2):89-97. PubMed PMID: 7730690.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS. AU - Beal,J E, AU - Olson,R, AU - Laubenstein,L, AU - Morales,J O, AU - Bellman,P, AU - Yangco,B, AU - Lefkowitz,L, AU - Plasse,T F, AU - Shepard,K V, PY - 1995/2/1/pubmed PY - 1995/2/1/medline PY - 1995/2/1/entrez SP - 89 EP - 97 JF - Journal of pain and symptom management JO - J Pain Symptom Manage VL - 10 IS - 2 N2 - The effects of dronabinol on appetite and weight were evaluated in 139 patients with AIDS-related anorexia and > or = 2.3 kg weight loss in a multi-institutional study. Patients were randomized to receive 2.5 mg dronabinol twice daily or placebo. Patients rated appetite, mood, and nausea by using a 100-mm visual analogue scale 3 days weekly. Efficacy was evaluable in 88 patients. Dronabinol was associated with increased appetite above baseline (38% vs 8% for placebo, P = 0.015), improvement in mood (10% vs -2%, P = 0.06), and decreased nausea (20% vs 7%; P = 0.05). Weight was stable in dronabinol patients, while placebo recipients had a mean loss of 0.4 kg (P = 0.14). Of the dronabinol patients, 22% gained > or = 2 kg, compared with 10.5% of placebo recipients (P = 0.11). Side effects were mostly mild to moderate in severity (euphoria, dizziness, thinking abnormalities); there was no difference in discontinued therapy between dronabinol (8.3%) and placebo (4.5%) recipients. Dronabinol was found to be safe and effective for anorexia associated with weight loss in patients with AIDS. SN - 0885-3924 UR - https://www.unboundmedicine.com/medline/citation/7730690/Dronabinol_as_a_treatment_for_anorexia_associated_with_weight_loss_in_patients_with_AIDS_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0885392494001174 DB - PRIME DP - Unbound Medicine ER -