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Incidence of late lepra reaction among multibacillary leprosy patients after MDT.
Int J Lepr Other Mycobact Dis. 1995 Mar; 63(1):18-22.IJ

Abstract

Multidrug therapy (MDT) recommended by the World Health Organization (WHO) had been administered in 1982 to a cohort of multibacillary (MB) leprosy patients. Treatment was administered for a minimum period of 2 years or until skin-smear negativity for acid-fast bacilli was achieved (whichever was later). Among 980 MB leprosy patients who completed treatment, 11 patients (1.1%) experienced lepra reactions during surveillance. Probable predictive factors are discussed. The incidence of lepra reaction seemed to be three times more common in borderline (BL) leprosy than in lepromatous (LL) leprosy. The majority of these events occurred during the first 3 years of surveillance. All of these episodes were treated with steroids without antileprosy chemotherapy. None of these patients was confirmed as experiencing a relapse during the subsequent period of surveillance.

Authors+Show Affiliations

Branch of Epidemiology and Leprosy Control, Schieffelin Leprosy Research and Training Center, Karigiri, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7730714

Citation

Vijayakumaran, P, et al. "Incidence of Late Lepra Reaction Among Multibacillary Leprosy Patients After MDT." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 63, no. 1, 1995, pp. 18-22.
Vijayakumaran P, Manimozhi N, Jesudasan K. Incidence of late lepra reaction among multibacillary leprosy patients after MDT. Int J Lepr Other Mycobact Dis. 1995;63(1):18-22.
Vijayakumaran, P., Manimozhi, N., & Jesudasan, K. (1995). Incidence of late lepra reaction among multibacillary leprosy patients after MDT. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 63(1), 18-22.
Vijayakumaran P, Manimozhi N, Jesudasan K. Incidence of Late Lepra Reaction Among Multibacillary Leprosy Patients After MDT. Int J Lepr Other Mycobact Dis. 1995;63(1):18-22. PubMed PMID: 7730714.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence of late lepra reaction among multibacillary leprosy patients after MDT. AU - Vijayakumaran,P, AU - Manimozhi,N, AU - Jesudasan,K, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 18 EP - 22 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 63 IS - 1 N2 - Multidrug therapy (MDT) recommended by the World Health Organization (WHO) had been administered in 1982 to a cohort of multibacillary (MB) leprosy patients. Treatment was administered for a minimum period of 2 years or until skin-smear negativity for acid-fast bacilli was achieved (whichever was later). Among 980 MB leprosy patients who completed treatment, 11 patients (1.1%) experienced lepra reactions during surveillance. Probable predictive factors are discussed. The incidence of lepra reaction seemed to be three times more common in borderline (BL) leprosy than in lepromatous (LL) leprosy. The majority of these events occurred during the first 3 years of surveillance. All of these episodes were treated with steroids without antileprosy chemotherapy. None of these patients was confirmed as experiencing a relapse during the subsequent period of surveillance. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/7730714/Incidence_of_late_lepra_reaction_among_multibacillary_leprosy_patients_after_MDT_ DB - PRIME DP - Unbound Medicine ER -