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Subclinical coeliac disease is a frequent cause of iron-deficiency anaemia.
Scand J Gastroenterol 1995; 30(2):153-6SJ

Abstract

BACKGROUND

Although it is known that anaemia may be the only presenting symptom in coeliac disease, prevalence figures of unsuspected coeliac disease in anaemic patients are not available. The aim of this study was to assess the clinical usefulness of antigliadin and antiendomysial antibody tests in the diagnostic algorithm of anaemic patients.

METHODS

Two hundred consecutive anaemic patients were tested for antigliadin antibodies, and those positive were also tested for antiendomysial antibodies. All patients positive for antigliadin and antiendomysial antibodies underwent intestinal biopsy.

RESULTS

Sixteen patients were antigliadin antibody-positive, and 10 were also antiendomysial antibody-positive. In all 10 a jejunal biopsy was consistent with coeliac disease (prevalence, 5%). This prevalence rose to 8.5% when patients with macrocytic anaemia or with microcytic anaemia due to previous bleeding or responsive to oral iron therapy were excluded from the calculation.

CONCLUSIONS

Coeliac disease is a frequent cause of iron-deficiency anaemia, and antigliadin and antiendomysial antibody tests should be always performed in the diagnostic algorithm of anaemic patients.

Authors+Show Affiliations

Dept. of Medical Pathology I, University of Bologna, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7732338

Citation

Corazza, G R., et al. "Subclinical Coeliac Disease Is a Frequent Cause of Iron-deficiency Anaemia." Scandinavian Journal of Gastroenterology, vol. 30, no. 2, 1995, pp. 153-6.
Corazza GR, Valentini RA, Andreani ML, et al. Subclinical coeliac disease is a frequent cause of iron-deficiency anaemia. Scand J Gastroenterol. 1995;30(2):153-6.
Corazza, G. R., Valentini, R. A., Andreani, M. L., D'Anchino, M., Leva, M. T., Ginaldi, L., ... Gasbarrini, G. (1995). Subclinical coeliac disease is a frequent cause of iron-deficiency anaemia. Scandinavian Journal of Gastroenterology, 30(2), pp. 153-6.
Corazza GR, et al. Subclinical Coeliac Disease Is a Frequent Cause of Iron-deficiency Anaemia. Scand J Gastroenterol. 1995;30(2):153-6. PubMed PMID: 7732338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subclinical coeliac disease is a frequent cause of iron-deficiency anaemia. AU - Corazza,G R, AU - Valentini,R A, AU - Andreani,M L, AU - D'Anchino,M, AU - Leva,M T, AU - Ginaldi,L, AU - De Feudis,L, AU - Quaglino,D, AU - Gasbarrini,G, PY - 1995/2/1/pubmed PY - 1995/2/1/medline PY - 1995/2/1/entrez SP - 153 EP - 6 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 30 IS - 2 N2 - BACKGROUND: Although it is known that anaemia may be the only presenting symptom in coeliac disease, prevalence figures of unsuspected coeliac disease in anaemic patients are not available. The aim of this study was to assess the clinical usefulness of antigliadin and antiendomysial antibody tests in the diagnostic algorithm of anaemic patients. METHODS: Two hundred consecutive anaemic patients were tested for antigliadin antibodies, and those positive were also tested for antiendomysial antibodies. All patients positive for antigliadin and antiendomysial antibodies underwent intestinal biopsy. RESULTS: Sixteen patients were antigliadin antibody-positive, and 10 were also antiendomysial antibody-positive. In all 10 a jejunal biopsy was consistent with coeliac disease (prevalence, 5%). This prevalence rose to 8.5% when patients with macrocytic anaemia or with microcytic anaemia due to previous bleeding or responsive to oral iron therapy were excluded from the calculation. CONCLUSIONS: Coeliac disease is a frequent cause of iron-deficiency anaemia, and antigliadin and antiendomysial antibody tests should be always performed in the diagnostic algorithm of anaemic patients. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/7732338/Subclinical_coeliac_disease_is_a_frequent_cause_of_iron_deficiency_anaemia_ L2 - http://www.tandfonline.com/doi/full/10.3109/00365529509093254 DB - PRIME DP - Unbound Medicine ER -