Tags

Type your tag names separated by a space and hit enter

Helicobacter pylori infection in gastric carcinoma.
Eur J Gastroenterol Hepatol 1994; 6 Suppl 1:S93-6EJ

Abstract

PURPOSE

This study was undertaken to compare the pathoclinical findings in gastric adenocarcinoma with serum IgG antibody to Helicobacter pylori.

MATERIALS AND METHODS

We examined 185 patients with histologically established gastric cancer. The presence of immunoglobulin (Ig)G antibody in the high molecular cell-associated antigen of H. pylori was determined by enzyme-linked immunosorbent assay. Pepsinogens I and II were measured by radioimmunoassay. The distribution of H. pylori on the gastric mucosa was assessed by the Campylobacter-like organism test and phenol red dye spraying.

RESULTS

H. pylori IgG antibody was detected in 93.1% of patients with gastric cancer (mean age 61.7 years), 94.3% of patients with early gastric cancer and 91.2% with advanced gastric cancer. No statistical difference in serology was observed between type of gastric cancer, depth of cancer invasion, tumor size or histology. Only in patients with diffuse-type cancer of the cardia was there a lower percentage of positive results (80.0%). The ratio of pepsinogen I to pepsinogen II was higher in the patients who exhibited no H. pylori antibodies.

CONCLUSIONS

H. pylori antibodies were common in patients with gastric cancer, and were not correlated with histological type nor stage of cancer. In the Niigata district, a higher percentage of patients with gastric carcinoma displayed H. pylori antibodies compared with other districts in Japan.

Authors+Show Affiliations

Division of Internal Medicine, Niigata Cancer Center Hospital, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7735944

Citation

Kato, T, et al. "Helicobacter Pylori Infection in Gastric Carcinoma." European Journal of Gastroenterology & Hepatology, vol. 6 Suppl 1, 1994, pp. S93-6.
Kato T, Saito Y, Niwa M, et al. Helicobacter pylori infection in gastric carcinoma. Eur J Gastroenterol Hepatol. 1994;6 Suppl 1:S93-6.
Kato, T., Saito, Y., Niwa, M., Inoue, H., Motoyama, N., Ogoshi, K., ... Asaka, M. (1994). Helicobacter pylori infection in gastric carcinoma. European Journal of Gastroenterology & Hepatology, 6 Suppl 1, pp. S93-6.
Kato T, et al. Helicobacter Pylori Infection in Gastric Carcinoma. Eur J Gastroenterol Hepatol. 1994;6 Suppl 1:S93-6. PubMed PMID: 7735944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori infection in gastric carcinoma. AU - Kato,T, AU - Saito,Y, AU - Niwa,M, AU - Inoue,H, AU - Motoyama,N, AU - Ogoshi,K, AU - Nashimoto,A, AU - Sasaki,J, AU - Sato,T, AU - Asaka,M, PY - 1994/12/1/pubmed PY - 1994/12/1/medline PY - 1994/12/1/entrez SP - S93 EP - 6 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 6 Suppl 1 N2 - PURPOSE: This study was undertaken to compare the pathoclinical findings in gastric adenocarcinoma with serum IgG antibody to Helicobacter pylori. MATERIALS AND METHODS: We examined 185 patients with histologically established gastric cancer. The presence of immunoglobulin (Ig)G antibody in the high molecular cell-associated antigen of H. pylori was determined by enzyme-linked immunosorbent assay. Pepsinogens I and II were measured by radioimmunoassay. The distribution of H. pylori on the gastric mucosa was assessed by the Campylobacter-like organism test and phenol red dye spraying. RESULTS: H. pylori IgG antibody was detected in 93.1% of patients with gastric cancer (mean age 61.7 years), 94.3% of patients with early gastric cancer and 91.2% with advanced gastric cancer. No statistical difference in serology was observed between type of gastric cancer, depth of cancer invasion, tumor size or histology. Only in patients with diffuse-type cancer of the cardia was there a lower percentage of positive results (80.0%). The ratio of pepsinogen I to pepsinogen II was higher in the patients who exhibited no H. pylori antibodies. CONCLUSIONS: H. pylori antibodies were common in patients with gastric cancer, and were not correlated with histological type nor stage of cancer. In the Niigata district, a higher percentage of patients with gastric carcinoma displayed H. pylori antibodies compared with other districts in Japan. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/7735944/Helicobacter_pylori_infection_in_gastric_carcinoma_ L2 - https://medlineplus.gov/helicobacterpyloriinfections.html DB - PRIME DP - Unbound Medicine ER -