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A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel.
Cell. 1995 Apr 21; 81(2):299-307.Cell

Abstract

Mutations in HERG cause an inherited cardiac arrhythmia, long QT syndrome (LQT). To define the function of HERG, we expressed the protein in Xenopus oocytes. The biophysical properties of expressed HERG are nearly identical to the rapidly activating delayed rectifier K+ current (IKr) in cardiac myocytes. HERG current is K+ selective, declines with depolarizations above 0 mV, is activated by extracellular K+, and is blocked by lanthanum. Interestingly, HERG current is not blocked by drugs that specifically block IKr in cardiac myocytes. These data indicate that HERG proteins form IKr channels, but that an additional subunit may be required for drug sensitivity. Since block of IKr is a known mechanism for drug-induced cardiac arrhythmias, the finding that HERG encodes IKr channels provides a mechanistic link between certain forms of inherited and acquired LQT.

Authors+Show Affiliations

Eccles Program in Human Molecular Biology and Genetics, University of Utah Health Sciences Center, Salt Lake City 84112, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7736582

Citation

Sanguinetti, M C., et al. "A Mechanistic Link Between an Inherited and an Acquired Cardiac Arrhythmia: HERG Encodes the IKr Potassium Channel." Cell, vol. 81, no. 2, 1995, pp. 299-307.
Sanguinetti MC, Jiang C, Curran ME, et al. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell. 1995;81(2):299-307.
Sanguinetti, M. C., Jiang, C., Curran, M. E., & Keating, M. T. (1995). A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell, 81(2), 299-307.
Sanguinetti MC, et al. A Mechanistic Link Between an Inherited and an Acquired Cardiac Arrhythmia: HERG Encodes the IKr Potassium Channel. Cell. 1995 Apr 21;81(2):299-307. PubMed PMID: 7736582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. AU - Sanguinetti,M C, AU - Jiang,C, AU - Curran,M E, AU - Keating,M T, PY - 1995/4/21/pubmed PY - 1995/4/21/medline PY - 1995/4/21/entrez SP - 299 EP - 307 JF - Cell JO - Cell VL - 81 IS - 2 N2 - Mutations in HERG cause an inherited cardiac arrhythmia, long QT syndrome (LQT). To define the function of HERG, we expressed the protein in Xenopus oocytes. The biophysical properties of expressed HERG are nearly identical to the rapidly activating delayed rectifier K+ current (IKr) in cardiac myocytes. HERG current is K+ selective, declines with depolarizations above 0 mV, is activated by extracellular K+, and is blocked by lanthanum. Interestingly, HERG current is not blocked by drugs that specifically block IKr in cardiac myocytes. These data indicate that HERG proteins form IKr channels, but that an additional subunit may be required for drug sensitivity. Since block of IKr is a known mechanism for drug-induced cardiac arrhythmias, the finding that HERG encodes IKr channels provides a mechanistic link between certain forms of inherited and acquired LQT. SN - 0092-8674 UR - https://www.unboundmedicine.com/medline/citation/7736582/A_mechanistic_link_between_an_inherited_and_an_acquired_cardiac_arrhythmia:_HERG_encodes_the_IKr_potassium_channel_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0092-8674(95)90340-2 DB - PRIME DP - Unbound Medicine ER -