Chiral sulfoxidation of albendazole by the flavin adenine dinucleotide-containing and cytochrome P450-dependent monooxygenases from rat liver microsomes.Drug Metab Dispos. 1995 Feb; 23(2):160-5.DM
Abstract
The enantioselectivity of the in vitro sulfoxidation of the prochiral drug albendazole was investigated in rat liver microsomes. When biological material obtained from control rats and phenobarbital-, 3-methylcholanthrene-, or dexamethazone-pretreated rats was subjected to specific immunological and chemical inhibitors, it was shown that two main enzymatic systems--cytochrome P450s and flavin-containing monooxygenase (FMO)--were responsible for the sulfoxidation. Purified FMO from rat liver was used to study the enantioselectivity of this enzyme in the sulfoxidation of albendazole. The enantiospecificity of FMO is the reverse of that of the P450s. Nevertheless, each P450 isoenzyme involved in this reaction presents its own individual stereoselectivity.
Links
MeSH
Pub Type(s)
Journal Article
Research Support, Non-U.S. Gov't
Language
eng
PubMed ID
7736906
Citation
Moroni, P, et al. "Chiral Sulfoxidation of Albendazole By the Flavin Adenine Dinucleotide-containing and Cytochrome P450-dependent Monooxygenases From Rat Liver Microsomes." Drug Metabolism and Disposition: the Biological Fate of Chemicals, vol. 23, no. 2, 1995, pp. 160-5.
Moroni P, Buronfosse T, Longin-Sauvageon C, et al. Chiral sulfoxidation of albendazole by the flavin adenine dinucleotide-containing and cytochrome P450-dependent monooxygenases from rat liver microsomes. Drug Metab Dispos. 1995;23(2):160-5.
Moroni, P., Buronfosse, T., Longin-Sauvageon, C., Delatour, P., & Benoit, E. (1995). Chiral sulfoxidation of albendazole by the flavin adenine dinucleotide-containing and cytochrome P450-dependent monooxygenases from rat liver microsomes. Drug Metabolism and Disposition: the Biological Fate of Chemicals, 23(2), 160-5.
Moroni P, et al. Chiral Sulfoxidation of Albendazole By the Flavin Adenine Dinucleotide-containing and Cytochrome P450-dependent Monooxygenases From Rat Liver Microsomes. Drug Metab Dispos. 1995;23(2):160-5. PubMed PMID: 7736906.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Chiral sulfoxidation of albendazole by the flavin adenine dinucleotide-containing and cytochrome P450-dependent monooxygenases from rat liver microsomes.
AU - Moroni,P,
AU - Buronfosse,T,
AU - Longin-Sauvageon,C,
AU - Delatour,P,
AU - Benoit,E,
PY - 1995/2/1/pubmed
PY - 1995/2/1/medline
PY - 1995/2/1/entrez
SP - 160
EP - 5
JF - Drug metabolism and disposition: the biological fate of chemicals
JO - Drug Metab Dispos
VL - 23
IS - 2
N2 - The enantioselectivity of the in vitro sulfoxidation of the prochiral drug albendazole was investigated in rat liver microsomes. When biological material obtained from control rats and phenobarbital-, 3-methylcholanthrene-, or dexamethazone-pretreated rats was subjected to specific immunological and chemical inhibitors, it was shown that two main enzymatic systems--cytochrome P450s and flavin-containing monooxygenase (FMO)--were responsible for the sulfoxidation. Purified FMO from rat liver was used to study the enantioselectivity of this enzyme in the sulfoxidation of albendazole. The enantiospecificity of FMO is the reverse of that of the P450s. Nevertheless, each P450 isoenzyme involved in this reaction presents its own individual stereoselectivity.
SN - 0090-9556
UR - https://www.unboundmedicine.com/medline/citation/7736906/Chiral_sulfoxidation_of_albendazole_by_the_flavin_adenine_dinucleotide_containing_and_cytochrome_P450_dependent_monooxygenases_from_rat_liver_microsomes_
L2 - http://dmd.aspetjournals.org/cgi/pmidlookup?view=long&pmid=7736906
DB - PRIME
DP - Unbound Medicine
ER -
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