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Muscarinic M1 receptor inhibition reduces gastroduodenal bicarbonate secretion and promotes gastric prostaglandin E2 synthesis in healthy volunteers.
Gut. 1995 Apr; 36(4):528-33.Gut

Abstract

The selective muscarinic M1 receptor antagonist, pirenzepine, considerably stimulates duodenal mucosal bicarbonate secretion in the rat and increases gastric luminal release of prostaglandin E2 (PGE2) in humans. This study, therefore, looked at the effect of pirenzepine on bicarbonate secretion and luminal output of PGE2 into the stomach and the duodenum of nine healthy volunteers using a new technique permitting simultaneous measurements. In the stomach modified sham feeding increased bicarbonate secretion from 382 (62) mumol/h (mean (SEM)) to 959 (224) mumol/h (p < 0.02). In the duodenum modified sham feeding and acid exposure (HCl 0.1 M; 20 ml; 5 min) of the duodenal bulb increased mucosal bicarbonate secretion from 191 (14) mumol/cm x h to 266 (27) mumol/cm x h (p < 0.02) and 634 (157) mumol/cm x h (p < 0.01), respectively. Pirenzepine (10 mg/h intravenously) reduced basal and vagally stimulated gastric and basal duodenal bicarbonate secretion by about 50% (p < 0.03). In the stomach, but not the duodenum, basal and vagally stimulated PGE2 output increased significantly (p < 0.05) in response to pirenzepine. In conclusion, human gastroduodenal mucosal bicarbonate secretion is regulated by a pirenzepine sensitive mechanism, which is probably cholinergic. The rise in gastric PGE2 output seen in response to M1 receptor inhibition by pirenzepine suggests the existence of a feed back loop secondary to the decrease seen in bicarbonate secretion.

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Authors+Show Affiliations

Mertz-Nielsen A
Department of Medical Gastroenterology, Hvidovre Hospital, Denmark.
Hillingsø J
No affiliation info available
Eskerod O
No affiliation info available
Bukhave K
No affiliation info available
Rask-Madsen J
No affiliation info available

MeSH

AdultBicarbonatesDepression, ChemicalDinoprostoneDuodenumFemaleGastric MucosaHumansMalePirenzepineReceptors, MuscarinicTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7737558

Citation

Mertz-Nielsen, A, et al. "Muscarinic M1 Receptor Inhibition Reduces Gastroduodenal Bicarbonate Secretion and Promotes Gastric Prostaglandin E2 Synthesis in Healthy Volunteers." Gut, vol. 36, no. 4, 1995, pp. 528-33.
Mertz-Nielsen A, Hillingsø J, Eskerod O, et al. Muscarinic M1 receptor inhibition reduces gastroduodenal bicarbonate secretion and promotes gastric prostaglandin E2 synthesis in healthy volunteers. Gut. 1995;36(4):528-33.
Mertz-Nielsen, A., Hillingsø, J., Eskerod, O., Bukhave, K., & Rask-Madsen, J. (1995). Muscarinic M1 receptor inhibition reduces gastroduodenal bicarbonate secretion and promotes gastric prostaglandin E2 synthesis in healthy volunteers. Gut, 36(4), 528-33.
Mertz-Nielsen A, et al. Muscarinic M1 Receptor Inhibition Reduces Gastroduodenal Bicarbonate Secretion and Promotes Gastric Prostaglandin E2 Synthesis in Healthy Volunteers. Gut. 1995;36(4):528-33. PubMed PMID: 7737558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Muscarinic M1 receptor inhibition reduces gastroduodenal bicarbonate secretion and promotes gastric prostaglandin E2 synthesis in healthy volunteers. AU - Mertz-Nielsen,A, AU - Hillingsø,J, AU - Eskerod,O, AU - Bukhave,K, AU - Rask-Madsen,J, PY - 1995/4/1/pubmed PY - 1995/4/1/medline PY - 1995/4/1/entrez SP - 528 EP - 33 JF - Gut JO - Gut VL - 36 IS - 4 N2 - The selective muscarinic M1 receptor antagonist, pirenzepine, considerably stimulates duodenal mucosal bicarbonate secretion in the rat and increases gastric luminal release of prostaglandin E2 (PGE2) in humans. This study, therefore, looked at the effect of pirenzepine on bicarbonate secretion and luminal output of PGE2 into the stomach and the duodenum of nine healthy volunteers using a new technique permitting simultaneous measurements. In the stomach modified sham feeding increased bicarbonate secretion from 382 (62) mumol/h (mean (SEM)) to 959 (224) mumol/h (p < 0.02). In the duodenum modified sham feeding and acid exposure (HCl 0.1 M; 20 ml; 5 min) of the duodenal bulb increased mucosal bicarbonate secretion from 191 (14) mumol/cm x h to 266 (27) mumol/cm x h (p < 0.02) and 634 (157) mumol/cm x h (p < 0.01), respectively. Pirenzepine (10 mg/h intravenously) reduced basal and vagally stimulated gastric and basal duodenal bicarbonate secretion by about 50% (p < 0.03). In the stomach, but not the duodenum, basal and vagally stimulated PGE2 output increased significantly (p < 0.05) in response to pirenzepine. In conclusion, human gastroduodenal mucosal bicarbonate secretion is regulated by a pirenzepine sensitive mechanism, which is probably cholinergic. The rise in gastric PGE2 output seen in response to M1 receptor inhibition by pirenzepine suggests the existence of a feed back loop secondary to the decrease seen in bicarbonate secretion. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/7737558/Muscarinic_M1_receptor_inhibition_reduces_gastroduodenal_bicarbonate_secretion_and_promotes_gastric_prostaglandin_E2_synthesis_in_healthy_volunteers_ L2 - https://gut.bmj.com/lookup/pmidlookup?view=long&amp;pmid=7737558 DB - PRIME DP - Unbound Medicine ER -