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A substantial proportion of non-ulcer dyspepsia patients have the same abnormality of acid secretion as duodenal ulcer patients.
Gut. 1995 Apr; 36(4):534-8.Gut

Abstract

Acid secretion in response to gastrin releasing peptide (GRP) is increased six-fold in Helicobacter pylori positive duodenal ulcer (DU) patients and threefold in H pylori positive healthy volunteers, and this fully resolves after eradication of the infection. This study was undertaken to determine whether a proportion of H pylori positive patients with non-ulcer dyspepsia (NUD) have an acid secretion disturbance similar to DU patients. Basal and GRP stimulated gastrin concentrations and acid output were examined in 25 H pylori positive NUD patients and the results compared with those of 25 H pylori positive healthy volunteers, 25 H pylori negative healthy volunteers, and 25 H pylori positive DU patients. Compared with the H pylori negative healthy volunteers, GRP stimulated gastrin was increased approximately three fold in each of the three infected groups. GRP stimulated acid secretion (median, range) was higher in the H pylori positive NUD patients (29.6 mmol/h (5.2-46.5)) (p < 0.005) than in the H pylori positive healthy volunteers (19.0 (1.0-38.3)) (p < 0.001) or H pylori negative healthy volunteers (6.3 (2.8-20.9)) (p < 0.0001). The H pylori positive NUD patients, however, had lower acid output than the DU patients (39.1 (17.9-64)) (p < 0.005). These findings are consistent with approximately 50% of the NUD patients having a similar disturbance of GRP stimulated acid secretion to DU patients.

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Authors+Show Affiliations

el-Omar E
University Department of Medicine and Therapeutics, Western Infirmary, Glasgow.
Penman I
No affiliation info available
Ardill JE
No affiliation info available
McColl KE
No affiliation info available

MeSH

AdolescentAdultDuodenal UlcerDyspepsiaFemaleGastric AcidGastrin-Releasing PeptideGastrinsGastrointestinal HormonesHelicobacter InfectionsHelicobacter pyloriHumansMaleMiddle AgedPeptidesStimulation, Chemical

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7737559

Citation

el-Omar, E, et al. "A Substantial Proportion of Non-ulcer Dyspepsia Patients Have the Same Abnormality of Acid Secretion as Duodenal Ulcer Patients." Gut, vol. 36, no. 4, 1995, pp. 534-8.
el-Omar E, Penman I, Ardill JE, et al. A substantial proportion of non-ulcer dyspepsia patients have the same abnormality of acid secretion as duodenal ulcer patients. Gut. 1995;36(4):534-8.
el-Omar, E., Penman, I., Ardill, J. E., & McColl, K. E. (1995). A substantial proportion of non-ulcer dyspepsia patients have the same abnormality of acid secretion as duodenal ulcer patients. Gut, 36(4), 534-8.
el-Omar E, et al. A Substantial Proportion of Non-ulcer Dyspepsia Patients Have the Same Abnormality of Acid Secretion as Duodenal Ulcer Patients. Gut. 1995;36(4):534-8. PubMed PMID: 7737559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A substantial proportion of non-ulcer dyspepsia patients have the same abnormality of acid secretion as duodenal ulcer patients. AU - el-Omar,E, AU - Penman,I, AU - Ardill,J E, AU - McColl,K E, PY - 1995/4/1/pubmed PY - 1995/4/1/medline PY - 1995/4/1/entrez SP - 534 EP - 8 JF - Gut JO - Gut VL - 36 IS - 4 N2 - Acid secretion in response to gastrin releasing peptide (GRP) is increased six-fold in Helicobacter pylori positive duodenal ulcer (DU) patients and threefold in H pylori positive healthy volunteers, and this fully resolves after eradication of the infection. This study was undertaken to determine whether a proportion of H pylori positive patients with non-ulcer dyspepsia (NUD) have an acid secretion disturbance similar to DU patients. Basal and GRP stimulated gastrin concentrations and acid output were examined in 25 H pylori positive NUD patients and the results compared with those of 25 H pylori positive healthy volunteers, 25 H pylori negative healthy volunteers, and 25 H pylori positive DU patients. Compared with the H pylori negative healthy volunteers, GRP stimulated gastrin was increased approximately three fold in each of the three infected groups. GRP stimulated acid secretion (median, range) was higher in the H pylori positive NUD patients (29.6 mmol/h (5.2-46.5)) (p < 0.005) than in the H pylori positive healthy volunteers (19.0 (1.0-38.3)) (p < 0.001) or H pylori negative healthy volunteers (6.3 (2.8-20.9)) (p < 0.0001). The H pylori positive NUD patients, however, had lower acid output than the DU patients (39.1 (17.9-64)) (p < 0.005). These findings are consistent with approximately 50% of the NUD patients having a similar disturbance of GRP stimulated acid secretion to DU patients. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/7737559/A_substantial_proportion_of_non_ulcer_dyspepsia_patients_have_the_same_abnormality_of_acid_secretion_as_duodenal_ulcer_patients_ L2 - https://gut.bmj.com/lookup/pmidlookup?view=long&amp;pmid=7737559 DB - PRIME DP - Unbound Medicine ER -