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Evaluation of the 3-drug combination, Rifater, versus 4-drug therapy in the ambulatory treatment of tuberculosis in Cape Town.
S Afr Med J 1994; 84(6):325-8SA

Abstract

The subjective impression among clinicians that the use of Rifater was causing delayed sputum conversion and increased drug resistance was tested in a prospective study. Adults in the Cape Town municipal area with a first episode of pulmonary tuberculosis were treated either with Rifater or a regimen consisting of isoniazid, rifampicin, pyrazinamide and ethambutol. All patients who took the treatment as prescribed (67 Rifater, 39 the 4-drug regimen) converted to a negative sputum culture by the time 90 doses had been taken. The rates of inadequate compliance and of side-effects were similar in the two groups. Drug sensitivity testing of bacteria cultured from pre-treatment sputum specimens revealed an overall primary resistance rate of 4.84% in the population studied, sufficiently low to preclude any necessity for routine pre-treatment drug sensitivity testing.

Authors+Show Affiliations

City Health Department, Cape Town.

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

7740377

Citation

Macnab, M F., et al. "Evaluation of the 3-drug Combination, Rifater, Versus 4-drug Therapy in the Ambulatory Treatment of Tuberculosis in Cape Town." South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde, vol. 84, no. 6, 1994, pp. 325-8.
Macnab MF, Bohmer PD, Seager JR. Evaluation of the 3-drug combination, Rifater, versus 4-drug therapy in the ambulatory treatment of tuberculosis in Cape Town. S Afr Med J. 1994;84(6):325-8.
Macnab, M. F., Bohmer, P. D., & Seager, J. R. (1994). Evaluation of the 3-drug combination, Rifater, versus 4-drug therapy in the ambulatory treatment of tuberculosis in Cape Town. South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde, 84(6), pp. 325-8.
Macnab MF, Bohmer PD, Seager JR. Evaluation of the 3-drug Combination, Rifater, Versus 4-drug Therapy in the Ambulatory Treatment of Tuberculosis in Cape Town. S Afr Med J. 1994;84(6):325-8. PubMed PMID: 7740377.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the 3-drug combination, Rifater, versus 4-drug therapy in the ambulatory treatment of tuberculosis in Cape Town. AU - Macnab,M F, AU - Bohmer,P D, AU - Seager,J R, PY - 1994/6/1/pubmed PY - 1994/6/1/medline PY - 1994/6/1/entrez SP - 325 EP - 8 JF - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde JO - S. Afr. Med. J. VL - 84 IS - 6 N2 - The subjective impression among clinicians that the use of Rifater was causing delayed sputum conversion and increased drug resistance was tested in a prospective study. Adults in the Cape Town municipal area with a first episode of pulmonary tuberculosis were treated either with Rifater or a regimen consisting of isoniazid, rifampicin, pyrazinamide and ethambutol. All patients who took the treatment as prescribed (67 Rifater, 39 the 4-drug regimen) converted to a negative sputum culture by the time 90 doses had been taken. The rates of inadequate compliance and of side-effects were similar in the two groups. Drug sensitivity testing of bacteria cultured from pre-treatment sputum specimens revealed an overall primary resistance rate of 4.84% in the population studied, sufficiently low to preclude any necessity for routine pre-treatment drug sensitivity testing. SN - 0256-9574 UR - https://www.unboundmedicine.com/medline/citation/7740377/Evaluation_of_the_3_drug_combination_Rifater_versus_4_drug_therapy_in_the_ambulatory_treatment_of_tuberculosis_in_Cape_Town_ L2 - http://www.diseaseinfosearch.org/result/7252 DB - PRIME DP - Unbound Medicine ER -