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Evaluation of the 3-drug combination, Rifater, versus 4-drug therapy in the ambulatory treatment of tuberculosis in Cape Town.
S Afr Med J. 1994 Jun; 84(6):325-8.SA

Abstract

The subjective impression among clinicians that the use of Rifater was causing delayed sputum conversion and increased drug resistance was tested in a prospective study. Adults in the Cape Town municipal area with a first episode of pulmonary tuberculosis were treated either with Rifater or a regimen consisting of isoniazid, rifampicin, pyrazinamide and ethambutol. All patients who took the treatment as prescribed (67 Rifater, 39 the 4-drug regimen) converted to a negative sputum culture by the time 90 doses had been taken. The rates of inadequate compliance and of side-effects were similar in the two groups. Drug sensitivity testing of bacteria cultured from pre-treatment sputum specimens revealed an overall primary resistance rate of 4.84% in the population studied, sufficiently low to preclude any necessity for routine pre-treatment drug sensitivity testing.

Authors+Show Affiliations

City Health Department, Cape Town.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

7740377

Citation

Macnab, M F., et al. "Evaluation of the 3-drug Combination, Rifater, Versus 4-drug Therapy in the Ambulatory Treatment of Tuberculosis in Cape Town." South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde, vol. 84, no. 6, 1994, pp. 325-8.
Macnab MF, Bohmer PD, Seager JR. Evaluation of the 3-drug combination, Rifater, versus 4-drug therapy in the ambulatory treatment of tuberculosis in Cape Town. S Afr Med J. 1994;84(6):325-8.
Macnab, M. F., Bohmer, P. D., & Seager, J. R. (1994). Evaluation of the 3-drug combination, Rifater, versus 4-drug therapy in the ambulatory treatment of tuberculosis in Cape Town. South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde, 84(6), 325-8.
Macnab MF, Bohmer PD, Seager JR. Evaluation of the 3-drug Combination, Rifater, Versus 4-drug Therapy in the Ambulatory Treatment of Tuberculosis in Cape Town. S Afr Med J. 1994;84(6):325-8. PubMed PMID: 7740377.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the 3-drug combination, Rifater, versus 4-drug therapy in the ambulatory treatment of tuberculosis in Cape Town. AU - Macnab,M F, AU - Bohmer,P D, AU - Seager,J R, PY - 1994/6/1/pubmed PY - 1994/6/1/medline PY - 1994/6/1/entrez SP - 325 EP - 8 JF - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde JO - S. Afr. Med. J. VL - 84 IS - 6 N2 - The subjective impression among clinicians that the use of Rifater was causing delayed sputum conversion and increased drug resistance was tested in a prospective study. Adults in the Cape Town municipal area with a first episode of pulmonary tuberculosis were treated either with Rifater or a regimen consisting of isoniazid, rifampicin, pyrazinamide and ethambutol. All patients who took the treatment as prescribed (67 Rifater, 39 the 4-drug regimen) converted to a negative sputum culture by the time 90 doses had been taken. The rates of inadequate compliance and of side-effects were similar in the two groups. Drug sensitivity testing of bacteria cultured from pre-treatment sputum specimens revealed an overall primary resistance rate of 4.84% in the population studied, sufficiently low to preclude any necessity for routine pre-treatment drug sensitivity testing. SN - 0256-9574 UR - https://www.unboundmedicine.com/medline/citation/7740377/Evaluation_of_the_3_drug_combination_Rifater_versus_4_drug_therapy_in_the_ambulatory_treatment_of_tuberculosis_in_Cape_Town_ L2 - http://www.diseaseinfosearch.org/result/7252 DB - PRIME DP - Unbound Medicine ER -