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d-fenfluramine, but not d-norfenfluramine, uses calcium to increase extracellular serotonin.
Life Sci. 1995; 56(22):PL415-20.LS

Abstract

Microdialysis in the hippocampus of freely moving rats was used to assess extracellular serotonin (5-HT) in response to local infusion of d-fenfluramine and its metabolite d-norfenfluramine with and without local calcium depletion. Verapamil (1 mM) in calcium-free Ringer infused via the microdialysis probe increased extracellular 5-HT and prevented the full increase in extracellular 5-HT normally caused by 1 mM d-fenfluramine. The results suggest d-fenfluramine might act in part as a calcium channel agonist favoring a calcium influx that in turn would trigger the exocytotic process in 5-HT terminals. d-norfenfluramine, on the other hand, was capable of releasing 5-HT, in vivo, in spite of depleted Ca levels.

Authors+Show Affiliations

Princeton University, Department of Psychology, NJ, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7746089

Citation

Puig de Parada, M, et al. "D-fenfluramine, but Not D-norfenfluramine, Uses Calcium to Increase Extracellular Serotonin." Life Sciences, vol. 56, no. 22, 1995, pp. PL415-20.
Puig de Parada M, Parada MA, Pothos E, et al. D-fenfluramine, but not d-norfenfluramine, uses calcium to increase extracellular serotonin. Life Sci. 1995;56(22):PL415-20.
Puig de Parada, M., Parada, M. A., Pothos, E., & Hoebel, B. G. (1995). D-fenfluramine, but not d-norfenfluramine, uses calcium to increase extracellular serotonin. Life Sciences, 56(22), PL415-20.
Puig de Parada M, et al. D-fenfluramine, but Not D-norfenfluramine, Uses Calcium to Increase Extracellular Serotonin. Life Sci. 1995;56(22):PL415-20. PubMed PMID: 7746089.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - d-fenfluramine, but not d-norfenfluramine, uses calcium to increase extracellular serotonin. AU - Puig de Parada,M, AU - Parada,M A, AU - Pothos,E, AU - Hoebel,B G, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - PL415 EP - 20 JF - Life sciences JO - Life Sci VL - 56 IS - 22 N2 - Microdialysis in the hippocampus of freely moving rats was used to assess extracellular serotonin (5-HT) in response to local infusion of d-fenfluramine and its metabolite d-norfenfluramine with and without local calcium depletion. Verapamil (1 mM) in calcium-free Ringer infused via the microdialysis probe increased extracellular 5-HT and prevented the full increase in extracellular 5-HT normally caused by 1 mM d-fenfluramine. The results suggest d-fenfluramine might act in part as a calcium channel agonist favoring a calcium influx that in turn would trigger the exocytotic process in 5-HT terminals. d-norfenfluramine, on the other hand, was capable of releasing 5-HT, in vivo, in spite of depleted Ca levels. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/7746089/d_fenfluramine_but_not_d_norfenfluramine_uses_calcium_to_increase_extracellular_serotonin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0024320595001686 DB - PRIME DP - Unbound Medicine ER -