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Cortical Lewy bodies in Alzheimer's disease.
Arch Pathol Lab Med. 1995 May; 119(5):448-53.AP

Abstract

Forty-eight cases of pathologically verified Alzheimer's disease were examined for the presence of ubiquitin-positive cortical Lewy bodies (CLBs). Thirty-four (71%) of 48 cases of Alzheimer's disease had CLBs compared with 4 (44%) of nine patients with idiopathic Parkinson's disease, and 2 (20%) of 10 patients with multi-infarct dementia. None of the 18 cognitively intact elderly controls we examined had CLBs. Among Alzheimer's disease patients, there was a strong correlation between CLBs and degenerative changes in the substantia nigra. We also found an association between the presence of CLBs and extrapyramidal symptoms. Among Alzheimer's disease patients, there was no association of CLBs with either senile plaques or neurons containing neurofibrillary tangles in hippocampus, neocortex, or ventral striatum. The incidence of CLBs among pathologically verified Alzheimer's disease cases is high when a careful search for these inclusions is performed with a sensitive method such as anti-ubiquitin immunocytochemistry.

Authors+Show Affiliations

Department of Pathology and Laboratory Medicine, University of Rochester, New York 14642, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7748074

Citation

Kazee, A M., and L Y. Han. "Cortical Lewy Bodies in Alzheimer's Disease." Archives of Pathology & Laboratory Medicine, vol. 119, no. 5, 1995, pp. 448-53.
Kazee AM, Han LY. Cortical Lewy bodies in Alzheimer's disease. Arch Pathol Lab Med. 1995;119(5):448-53.
Kazee, A. M., & Han, L. Y. (1995). Cortical Lewy bodies in Alzheimer's disease. Archives of Pathology & Laboratory Medicine, 119(5), 448-53.
Kazee AM, Han LY. Cortical Lewy Bodies in Alzheimer's Disease. Arch Pathol Lab Med. 1995;119(5):448-53. PubMed PMID: 7748074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cortical Lewy bodies in Alzheimer's disease. AU - Kazee,A M, AU - Han,L Y, PY - 1995/5/1/pubmed PY - 1995/5/1/medline PY - 1995/5/1/entrez SP - 448 EP - 53 JF - Archives of pathology & laboratory medicine JO - Arch Pathol Lab Med VL - 119 IS - 5 N2 - Forty-eight cases of pathologically verified Alzheimer's disease were examined for the presence of ubiquitin-positive cortical Lewy bodies (CLBs). Thirty-four (71%) of 48 cases of Alzheimer's disease had CLBs compared with 4 (44%) of nine patients with idiopathic Parkinson's disease, and 2 (20%) of 10 patients with multi-infarct dementia. None of the 18 cognitively intact elderly controls we examined had CLBs. Among Alzheimer's disease patients, there was a strong correlation between CLBs and degenerative changes in the substantia nigra. We also found an association between the presence of CLBs and extrapyramidal symptoms. Among Alzheimer's disease patients, there was no association of CLBs with either senile plaques or neurons containing neurofibrillary tangles in hippocampus, neocortex, or ventral striatum. The incidence of CLBs among pathologically verified Alzheimer's disease cases is high when a careful search for these inclusions is performed with a sensitive method such as anti-ubiquitin immunocytochemistry. SN - 0003-9985 UR - https://www.unboundmedicine.com/medline/citation/7748074/Cortical_Lewy_bodies_in_Alzheimer's_disease_ DB - PRIME DP - Unbound Medicine ER -