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Studies on the release of histamine from isolated guinea pig mast cells stimulated by ionophore A23187 or by the anaphylactic reaction.
Naunyn Schmiedebergs Arch Pharmacol. 1978 Apr; 302(2):165-72.NS

Abstract

The divalent cation ionophore A23187 was found to produce a dose-dependent release of histamine from isolated mesenteric mast cells of the guinea pig. The process showed a specific requirement for calcium ions and was blocked by inhibitors of glycolysis. The effect of cAMP, theophylline, sympathomimetic amines and DSCG on the histamine release induced by the ionophore or by the antigen-antibody reaction was compared. In both cases, the release was inhibited by Bu2cAMP and by theophylline but higher concentrations were required with the ionophore. Adrenaline, isoprenaline and DSCG were effective only in the anaphylactic system. These results are compared with those previously reported for human leucocytes and rat peritoneal mast cells in which the release produced by the ionophore was found not to be inhibited by cAMP and its analogues. On the basis of these findings, the possible role of cAMP in the modulation of histamine release is discussed.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

77481

Citation

Pearce, F L., et al. "Studies On the Release of Histamine From Isolated Guinea Pig Mast Cells Stimulated By Ionophore A23187 or By the Anaphylactic Reaction." Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 302, no. 2, 1978, pp. 165-72.
Pearce FL, Blum U, Poblete-Freundt G, et al. Studies on the release of histamine from isolated guinea pig mast cells stimulated by ionophore A23187 or by the anaphylactic reaction. Naunyn Schmiedebergs Arch Pharmacol. 1978;302(2):165-72.
Pearce, F. L., Blum, U., Poblete-Freundt, G., & Schmutzler, W. (1978). Studies on the release of histamine from isolated guinea pig mast cells stimulated by ionophore A23187 or by the anaphylactic reaction. Naunyn-Schmiedeberg's Archives of Pharmacology, 302(2), 165-72.
Pearce FL, et al. Studies On the Release of Histamine From Isolated Guinea Pig Mast Cells Stimulated By Ionophore A23187 or By the Anaphylactic Reaction. Naunyn Schmiedebergs Arch Pharmacol. 1978;302(2):165-72. PubMed PMID: 77481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Studies on the release of histamine from isolated guinea pig mast cells stimulated by ionophore A23187 or by the anaphylactic reaction. AU - Pearce,F L, AU - Blum,U, AU - Poblete-Freundt,G, AU - Schmutzler,W, PY - 1978/4/1/pubmed PY - 1978/4/1/medline PY - 1978/4/1/entrez SP - 165 EP - 72 JF - Naunyn-Schmiedeberg's archives of pharmacology JO - Naunyn Schmiedebergs Arch Pharmacol VL - 302 IS - 2 N2 - The divalent cation ionophore A23187 was found to produce a dose-dependent release of histamine from isolated mesenteric mast cells of the guinea pig. The process showed a specific requirement for calcium ions and was blocked by inhibitors of glycolysis. The effect of cAMP, theophylline, sympathomimetic amines and DSCG on the histamine release induced by the ionophore or by the antigen-antibody reaction was compared. In both cases, the release was inhibited by Bu2cAMP and by theophylline but higher concentrations were required with the ionophore. Adrenaline, isoprenaline and DSCG were effective only in the anaphylactic system. These results are compared with those previously reported for human leucocytes and rat peritoneal mast cells in which the release produced by the ionophore was found not to be inhibited by cAMP and its analogues. On the basis of these findings, the possible role of cAMP in the modulation of histamine release is discussed. SN - 0028-1298 UR - https://www.unboundmedicine.com/medline/citation/77481/Studies_on_the_release_of_histamine_from_isolated_guinea_pig_mast_cells_stimulated_by_ionophore_A23187_or_by_the_anaphylactic_reaction_ DB - PRIME DP - Unbound Medicine ER -