[Prevalence of biliary lithiasis in cirrhotics: necropsy evaluation].Arq Gastroenterol. 1994 Jul-Sep; 31(3):92-6.AG
In order to investigate a possible association between hepatic cirrhosis and biliary lithiasis, an analysis on 3,332 necropsy report diagnosis was carried out. Gallstones were present in 19.5% of 123 cirrhotics and in 4.9% of 3,209 non-cirrhotics patients. We concluded that lithiasis is significantly more frequent in cirrhotics than in non-cirrhotics. Chronic hemolysis, slow emptying of the gallbladder, and defective bile acidification by the gallbladder would explain such association. The male-to-female ratio of lithiasis occurrence was 2.08:1 in the cirrhotic group and 2.4:1 among the non-cirrhotics. This difference was not significant. Pigmentary gallstones were commoner among cirrhotics and significantly more frequent in cirrhotics than in non-cirrhotics. This would be explained by chronic hemolysis and by bilirubin conjugation defects. Lithiasis was more frequent in secondary biliary cirrhosis, followed by postnecrotic cirrhosis of viral etiology.