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Hereditary cancer in adults.
Cancer Detect Prev 1995; 19(3):219-33CD

Abstract

Primary genetic factors play a major etiologic role in approximately 5% to 10% of the total cancer burden. Since the bulk of hereditary forms of cancer lack premonitory physical stigmata of cancer risk, a well-orchestrated family history is mandatory for establishing a hereditary cancer syndrome diagnosis. Knowledge of the natural history of the particular hereditary form of cancer will aid the physician in the development and implementation of highly targeted surveillance strategies. Indeed, specific natural history features of cancer, particularly early age onset and multiple primary cancer excess, characterize the more than 200 mendelian inherited cancer syndromes. The veritable explosive developments in molecular biology now enable the identification of germline mutations so that, in certain hereditary cancers, a simple blood test will enable the physician to determine the cancer destiny of patients carrying the particular germline mutation.

Authors+Show Affiliations

Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, NE 68178, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

7750110

Citation

Lynch, H T., et al. "Hereditary Cancer in Adults." Cancer Detection and Prevention, vol. 19, no. 3, 1995, pp. 219-33.
Lynch HT, Fusaro RM, Lynch J. Hereditary cancer in adults. Cancer Detect Prev. 1995;19(3):219-33.
Lynch, H. T., Fusaro, R. M., & Lynch, J. (1995). Hereditary cancer in adults. Cancer Detection and Prevention, 19(3), pp. 219-33.
Lynch HT, Fusaro RM, Lynch J. Hereditary Cancer in Adults. Cancer Detect Prev. 1995;19(3):219-33. PubMed PMID: 7750110.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hereditary cancer in adults. AU - Lynch,H T, AU - Fusaro,R M, AU - Lynch,J, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 219 EP - 33 JF - Cancer detection and prevention JO - Cancer Detect. Prev. VL - 19 IS - 3 N2 - Primary genetic factors play a major etiologic role in approximately 5% to 10% of the total cancer burden. Since the bulk of hereditary forms of cancer lack premonitory physical stigmata of cancer risk, a well-orchestrated family history is mandatory for establishing a hereditary cancer syndrome diagnosis. Knowledge of the natural history of the particular hereditary form of cancer will aid the physician in the development and implementation of highly targeted surveillance strategies. Indeed, specific natural history features of cancer, particularly early age onset and multiple primary cancer excess, characterize the more than 200 mendelian inherited cancer syndromes. The veritable explosive developments in molecular biology now enable the identification of germline mutations so that, in certain hereditary cancers, a simple blood test will enable the physician to determine the cancer destiny of patients carrying the particular germline mutation. SN - 0361-090X UR - https://www.unboundmedicine.com/medline/citation/7750110/Hereditary_cancer_in_adults_ L2 - http://www.diseaseinfosearch.org/result/3345 DB - PRIME DP - Unbound Medicine ER -