Tags

Type your tag names separated by a space and hit enter

Antimicrobial agents from higher plants. Additional alkaloids and antimicrobial agents from Thalictrum rugosum.
Lloydia. 1976 Jan-Feb; 39(1):65-75.L

Abstract

Further study of mother-liquors from ethanolic extracts of Thalictrum rugosum resulted in the identification or partial characterization of 10 alkaloids, bringing the total to 17 characterized in our work on this plant. Five of the new alkaloids were active in vitro against microorganisms. Structures, based upon spectroscopic properties and chemical transformations, are proposed for a new bisbenzylisoquinoline alkaloid named thalrugosaminine, and a protopine alkaloid named protothalipine. A phenanthrene base (thaliglucinone), an aporphine (thalphenine), and three protoberberine bases (columbamine, thalifendine and deoxythalidastine) were identified; three very minor bases of unknown identify were partially characterized.

Authors

Wu WN
No affiliation info available
Beal JL
No affiliation info available
Clark GW
No affiliation info available
Mitscher LA
No affiliation info available

MeSH

AlkaloidsAnti-Bacterial AgentsAntifungal AgentsCandida albicansEscherichia coliKlebsiella pneumoniaeMicrobial Sensitivity TestsMycobacteriumPlants, MedicinalSalmonellaStaphylococcus aureusStructure-Activity Relationship

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

775233

Citation

Wu, W N., et al. "Antimicrobial Agents From Higher Plants. Additional Alkaloids and Antimicrobial Agents From Thalictrum Rugosum." Lloydia, vol. 39, no. 1, 1976, pp. 65-75.
Wu WN, Beal JL, Clark GW, et al. Antimicrobial agents from higher plants. Additional alkaloids and antimicrobial agents from Thalictrum rugosum. Lloydia. 1976;39(1):65-75.
Wu, W. N., Beal, J. L., Clark, G. W., & Mitscher, L. A. (1976). Antimicrobial agents from higher plants. Additional alkaloids and antimicrobial agents from Thalictrum rugosum. Lloydia, 39(1), 65-75.
Wu WN, et al. Antimicrobial Agents From Higher Plants. Additional Alkaloids and Antimicrobial Agents From Thalictrum Rugosum. Lloydia. 1976 Jan-Feb;39(1):65-75. PubMed PMID: 775233.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial agents from higher plants. Additional alkaloids and antimicrobial agents from Thalictrum rugosum. AU - Wu,W N, AU - Beal,J L, AU - Clark,G W, AU - Mitscher,L A, PY - 1976/1/1/pubmed PY - 1976/1/1/medline PY - 1976/1/1/entrez SP - 65 EP - 75 JF - Lloydia JO - Lloydia VL - 39 IS - 1 N2 - Further study of mother-liquors from ethanolic extracts of Thalictrum rugosum resulted in the identification or partial characterization of 10 alkaloids, bringing the total to 17 characterized in our work on this plant. Five of the new alkaloids were active in vitro against microorganisms. Structures, based upon spectroscopic properties and chemical transformations, are proposed for a new bisbenzylisoquinoline alkaloid named thalrugosaminine, and a protopine alkaloid named protothalipine. A phenanthrene base (thaliglucinone), an aporphine (thalphenine), and three protoberberine bases (columbamine, thalifendine and deoxythalidastine) were identified; three very minor bases of unknown identify were partially characterized. SN - 0024-5461 UR - https://www.unboundmedicine.com/medline/citation/775233/Antimicrobial_agents_from_higher_plants__Additional_alkaloids_and_antimicrobial_agents_from_Thalictrum_rugosum_ DB - PRIME DP - Unbound Medicine ER -