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A systematic approach to macrocytosis. Sorting out the causes.
Postgrad Med. 1995 May; 97(5):171-2, 175-7, 181-4 passim.PM

Abstract

Because of the widespread use of multiparameter hematology instruments, physicians are often presented with patients who have macrocytosis with no obvious cause. Depending on the demographics of an individual practice, folate and vitamin B12 deficiencies may be relatively rare causes of macrocytosis, compared with alcoholism, liver disease, drugs, or myelodysplasia. Initial evaluation should include a carefully taken history and physical examination along with a complete hematologic profile, reticulocyte count, and peripheral blood smear. This initial evaluation should allow systematic consideration of the possible causes. Serum B12 and red cell folate determinations and other studies may then be undertaken as appropriate.

Authors+Show Affiliations

Island Medical Laboratories, Victoria, BC, Canada.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

7753741

Citation

Brigden, M L.. "A Systematic Approach to Macrocytosis. Sorting Out the Causes." Postgraduate Medicine, vol. 97, no. 5, 1995, 171-2, 175-7, 181-4 passim.
Brigden ML. A systematic approach to macrocytosis. Sorting out the causes. Postgrad Med. 1995;97(5):171-2, 175-7, 181-4 passim.
Brigden, M. L. (1995). A systematic approach to macrocytosis. Sorting out the causes. Postgraduate Medicine, 97(5), 171-2, 175-7, 181-4 passim.
Brigden ML. A Systematic Approach to Macrocytosis. Sorting Out the Causes. Postgrad Med. 1995;97(5):171-2, 175-7, 181-4 passim. PubMed PMID: 7753741.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A systematic approach to macrocytosis. Sorting out the causes. A1 - Brigden,M L, PY - 1995/5/1/pubmed PY - 1995/5/1/medline PY - 1995/5/1/entrez SP - 171-2, 175-7, 181-4 passim JF - Postgraduate medicine JO - Postgrad Med VL - 97 IS - 5 N2 - Because of the widespread use of multiparameter hematology instruments, physicians are often presented with patients who have macrocytosis with no obvious cause. Depending on the demographics of an individual practice, folate and vitamin B12 deficiencies may be relatively rare causes of macrocytosis, compared with alcoholism, liver disease, drugs, or myelodysplasia. Initial evaluation should include a carefully taken history and physical examination along with a complete hematologic profile, reticulocyte count, and peripheral blood smear. This initial evaluation should allow systematic consideration of the possible causes. Serum B12 and red cell folate determinations and other studies may then be undertaken as appropriate. SN - 0032-5481 UR - https://www.unboundmedicine.com/medline/citation/7753741/A_systematic_approach_to_macrocytosis__Sorting_out_the_causes_ L2 - https://medlineplus.gov/neuraltubedefects.html DB - PRIME DP - Unbound Medicine ER -