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Effect of different coffees on esophageal acid contact time and symptoms in coffee-sensitive subjects.
Physiol Behav 1995; 57(3):563-7PB

Abstract

The purpose of this study was to correlate the effects of different coffees on esophageal acid contact, heartburn, and regurgitation in patients with coffee-sensitivity. Twenty volunteers with coffee-sensitivity were studied in a double-blind, 3 period, crossover study examining the effect of three regular (caffeinated) coffees (a coffee from the USA--"A"; a "treated" coffee from Europe--"B"; and an "untreated" coffee from Europe--"C") before and after a high-fat test meal. The median acid contact times for coffees A, B, and C were 6.5%, 9%, and 10.5%, respectively (A vs. C, p = 0.005). Significantly fewer patients reported any symptoms with coffee A compared with coffee C (p < 0.05). Symptoms were usually more frequent and severe after the test meal. There was a trend toward fewer and less severe symptoms with the treated coffee (B) compared with its untreated counterpart (C). Our conclusions are as follows: (a) Different coffees induce variations in gastroesophageal reflux in coffee-sensitive individuals. (b) Coffee can be treated in a manner which decreases heartburn symptoms by 75% while decreasing acid contact by only 14%. (c) Gastroesophageal reflux and symptoms of coffee sensitivity increase with the concomitant ingestion of food. (d) Symptoms of dyspepsia appear to be influenced by variations in both the coffee itself and characteristics of susceptible individuals. (e) Although gastroesophageal reflux is important in the genesis of coffee-sensitivity, there must be other factors which act in concert with reflux to produce symptoms of coffee-sensitivity.

Authors+Show Affiliations

Department of Medicine, Duke University Medical Center, Durham, NC, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

7753895

Citation

Brazer, S R., et al. "Effect of Different Coffees On Esophageal Acid Contact Time and Symptoms in Coffee-sensitive Subjects." Physiology & Behavior, vol. 57, no. 3, 1995, pp. 563-7.
Brazer SR, Onken JE, Dalton CB, et al. Effect of different coffees on esophageal acid contact time and symptoms in coffee-sensitive subjects. Physiol Behav. 1995;57(3):563-7.
Brazer, S. R., Onken, J. E., Dalton, C. B., Smith, J. W., & Schiffman, S. S. (1995). Effect of different coffees on esophageal acid contact time and symptoms in coffee-sensitive subjects. Physiology & Behavior, 57(3), pp. 563-7.
Brazer SR, et al. Effect of Different Coffees On Esophageal Acid Contact Time and Symptoms in Coffee-sensitive Subjects. Physiol Behav. 1995;57(3):563-7. PubMed PMID: 7753895.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of different coffees on esophageal acid contact time and symptoms in coffee-sensitive subjects. AU - Brazer,S R, AU - Onken,J E, AU - Dalton,C B, AU - Smith,J W, AU - Schiffman,S S, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 563 EP - 7 JF - Physiology & behavior JO - Physiol. Behav. VL - 57 IS - 3 N2 - The purpose of this study was to correlate the effects of different coffees on esophageal acid contact, heartburn, and regurgitation in patients with coffee-sensitivity. Twenty volunteers with coffee-sensitivity were studied in a double-blind, 3 period, crossover study examining the effect of three regular (caffeinated) coffees (a coffee from the USA--"A"; a "treated" coffee from Europe--"B"; and an "untreated" coffee from Europe--"C") before and after a high-fat test meal. The median acid contact times for coffees A, B, and C were 6.5%, 9%, and 10.5%, respectively (A vs. C, p = 0.005). Significantly fewer patients reported any symptoms with coffee A compared with coffee C (p < 0.05). Symptoms were usually more frequent and severe after the test meal. There was a trend toward fewer and less severe symptoms with the treated coffee (B) compared with its untreated counterpart (C). Our conclusions are as follows: (a) Different coffees induce variations in gastroesophageal reflux in coffee-sensitive individuals. (b) Coffee can be treated in a manner which decreases heartburn symptoms by 75% while decreasing acid contact by only 14%. (c) Gastroesophageal reflux and symptoms of coffee sensitivity increase with the concomitant ingestion of food. (d) Symptoms of dyspepsia appear to be influenced by variations in both the coffee itself and characteristics of susceptible individuals. (e) Although gastroesophageal reflux is important in the genesis of coffee-sensitivity, there must be other factors which act in concert with reflux to produce symptoms of coffee-sensitivity. SN - 0031-9384 UR - https://www.unboundmedicine.com/medline/citation/7753895/Effect_of_different_coffees_on_esophageal_acid_contact_time_and_symptoms_in_coffee_sensitive_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0031-9384(94)00363-A DB - PRIME DP - Unbound Medicine ER -