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Fetal cleft lip with and without cleft palate: US classification and correlation with outcome.
Radiology. 1995 Jun; 195(3):677-84.R

Abstract

PURPOSE

To develop a prenatal ultrasonographic (US) classification of cleft lip with or without cleft palate (CL-P) and correlate the classification with fetal outcome.

MATERIALS AND METHODS

During a 5-year period (1988 to 1993), 65 fetuses with CL-P were identified with prenatal US at one of two referral centers for high-risk obstetric cases. Sonograms from each case were prospectively and retrospectively evaluated. Clefts were classified into one of five categories: type 1, cleft lip alone (n = 5); type 2, unilateral cleft lip and palate (n = 15); type 3, bilateral cleft lip and palate (n = 20); type 4, midline cleft lip and palate (n = 21); and type 5, facial defects associated with amniotic bands or limb-body-wall complex (n = 4).

RESULTS

The US classification correlated with severity of defect and fetal outcome. Type 4 and 5 clefts were universally associated with concurrent anomalies and a fetal outcome, type 1 clefts with a lower rate of anomalies (20%), and type 2 and 3 clefts with intermediate prognosis. Chromosome abnormalities also varied with the type of cleft as follows: type 1, 0%; type 2, 20%; type 3, 30%; type 4, 52%; and type 5, 0%.

CONCLUSION

Prenatal classification of fetal CL-P correlates with fetal outcome. This classification should help counseling and management.

Authors+Show Affiliations

Nyberg DA
Department of Ultrasound, Swedish Hospital Medical Center, Seattle, Wash, USA.
Sickler GK
No affiliation info available
Hegge FN
No affiliation info available
Kramer DJ
No affiliation info available
Kropp RJ
No affiliation info available

MeSH

Abnormalities, MultipleCleft LipCleft PalateFemaleFetal DiseasesHumansInfant, NewbornPregnancyProspective StudiesRetrospective StudiesUltrasonography, Prenatal

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7753993

Citation

Nyberg, D A., et al. "Fetal Cleft Lip With and Without Cleft Palate: US Classification and Correlation With Outcome." Radiology, vol. 195, no. 3, 1995, pp. 677-84.
Nyberg DA, Sickler GK, Hegge FN, et al. Fetal cleft lip with and without cleft palate: US classification and correlation with outcome. Radiology. 1995;195(3):677-84.
Nyberg, D. A., Sickler, G. K., Hegge, F. N., Kramer, D. J., & Kropp, R. J. (1995). Fetal cleft lip with and without cleft palate: US classification and correlation with outcome. Radiology, 195(3), 677-84.
Nyberg DA, et al. Fetal Cleft Lip With and Without Cleft Palate: US Classification and Correlation With Outcome. Radiology. 1995;195(3):677-84. PubMed PMID: 7753993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fetal cleft lip with and without cleft palate: US classification and correlation with outcome. AU - Nyberg,D A, AU - Sickler,G K, AU - Hegge,F N, AU - Kramer,D J, AU - Kropp,R J, PY - 1995/6/1/pubmed PY - 1995/6/1/medline PY - 1995/6/1/entrez SP - 677 EP - 84 JF - Radiology JO - Radiology VL - 195 IS - 3 N2 - PURPOSE: To develop a prenatal ultrasonographic (US) classification of cleft lip with or without cleft palate (CL-P) and correlate the classification with fetal outcome. MATERIALS AND METHODS: During a 5-year period (1988 to 1993), 65 fetuses with CL-P were identified with prenatal US at one of two referral centers for high-risk obstetric cases. Sonograms from each case were prospectively and retrospectively evaluated. Clefts were classified into one of five categories: type 1, cleft lip alone (n = 5); type 2, unilateral cleft lip and palate (n = 15); type 3, bilateral cleft lip and palate (n = 20); type 4, midline cleft lip and palate (n = 21); and type 5, facial defects associated with amniotic bands or limb-body-wall complex (n = 4). RESULTS: The US classification correlated with severity of defect and fetal outcome. Type 4 and 5 clefts were universally associated with concurrent anomalies and a fetal outcome, type 1 clefts with a lower rate of anomalies (20%), and type 2 and 3 clefts with intermediate prognosis. Chromosome abnormalities also varied with the type of cleft as follows: type 1, 0%; type 2, 20%; type 3, 30%; type 4, 52%; and type 5, 0%. CONCLUSION: Prenatal classification of fetal CL-P correlates with fetal outcome. This classification should help counseling and management. SN - 0033-8419 UR - https://www.unboundmedicine.com/medline/citation/7753993/Fetal_cleft_lip_with_and_without_cleft_palate:_US_classification_and_correlation_with_outcome_ DB - PRIME DP - Unbound Medicine ER -