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The apolipoprotein E epsilon 2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival.
Ann Neurol. 1995 May; 37(5):605-10.AN

Abstract

It was suggested that in contrast to the E4 allele, the E2 allele of the apolipoprotein E gene (APOE*2) has a protective effect for late-onset Alzheimer's disease and early-onset Alzheimer's disease (EOAD). We studied the role of the APOE*2 allele in the pathogenesis of EOAD in a Dutch population-based study of 175 probable EOAD patients with onset age at or before 65 years and 532 age-matched controls. In our population, there was no evidence for a protective effect of the APOE*2 allele on the risk of EOAD. However, our data show that among EOAD patients, survival for APOE*2 carriers was significantly reduced. When restricting the analysis to patients ascertained early after diagnosis at a stage of disease when mortality is low, our data suggest an increased risk of EOAD for subjects with APOE2E2, APOE2E3, APOE3E4, and APOE4E4 genotypes.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7755355

Citation

van Duijn, C M., et al. "The Apolipoprotein E Epsilon 2 Allele Is Associated With an Increased Risk of Early-onset Alzheimer's Disease and a Reduced Survival." Annals of Neurology, vol. 37, no. 5, 1995, pp. 605-10.
van Duijn CM, de Knijff P, Wehnert A, et al. The apolipoprotein E epsilon 2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival. Ann Neurol. 1995;37(5):605-10.
van Duijn, C. M., de Knijff, P., Wehnert, A., De Voecht, J., Bronzova, J. B., Havekes, L. M., Hofman, A., & Van Broeckhoven, C. (1995). The apolipoprotein E epsilon 2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival. Annals of Neurology, 37(5), 605-10.
van Duijn CM, et al. The Apolipoprotein E Epsilon 2 Allele Is Associated With an Increased Risk of Early-onset Alzheimer's Disease and a Reduced Survival. Ann Neurol. 1995;37(5):605-10. PubMed PMID: 7755355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The apolipoprotein E epsilon 2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival. AU - van Duijn,C M, AU - de Knijff,P, AU - Wehnert,A, AU - De Voecht,J, AU - Bronzova,J B, AU - Havekes,L M, AU - Hofman,A, AU - Van Broeckhoven,C, PY - 1995/5/1/pubmed PY - 1995/5/1/medline PY - 1995/5/1/entrez SP - 605 EP - 10 JF - Annals of neurology JO - Ann. Neurol. VL - 37 IS - 5 N2 - It was suggested that in contrast to the E4 allele, the E2 allele of the apolipoprotein E gene (APOE*2) has a protective effect for late-onset Alzheimer's disease and early-onset Alzheimer's disease (EOAD). We studied the role of the APOE*2 allele in the pathogenesis of EOAD in a Dutch population-based study of 175 probable EOAD patients with onset age at or before 65 years and 532 age-matched controls. In our population, there was no evidence for a protective effect of the APOE*2 allele on the risk of EOAD. However, our data show that among EOAD patients, survival for APOE*2 carriers was significantly reduced. When restricting the analysis to patients ascertained early after diagnosis at a stage of disease when mortality is low, our data suggest an increased risk of EOAD for subjects with APOE2E2, APOE2E3, APOE3E4, and APOE4E4 genotypes. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/7755355/The_apolipoprotein_E_epsilon_2_allele_is_associated_with_an_increased_risk_of_early_onset_Alzheimer's_disease_and_a_reduced_survival_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1995&volume=37&issue=5&spage=605 DB - PRIME DP - Unbound Medicine ER -