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Protection of neonatal kittens against feline immunodeficiency virus infection with passive maternal antiviral antibodies.
AIDS. 1995 Mar; 9(3):235-42.AIDS

Abstract

OBJECTIVE

Maternal antibodies from either vaccinated or feline immunodeficiency virus (FIV)-infected female cats (queens) were evaluated for their ability to protect kittens against homologous FIV infection.

DESIGN

Kittens that received different levels of maternal antiviral antibodies from either vaccinated or infected queens were inoculated with homologous FIV at 1 week post-parturition and monitored for FIV infection. Maternal antiviral antibodies in the kittens were also measured and compared to the level of FIV infection.

METHODS

Kittens at 1 week post-parturition were inoculated intraperitoneally with five median cat infectious doses of FIVPet. FIV infection was monitored by virus isolation for infectious FIV and by nested polymerase chain reaction for proviral DNA. Virus-neutralizing (VN) antibodies and antibodies to FIV transmembrane peptide and core protein were also monitored throughout the 25 weeks.

RESULTS

Neonatal kittens that received high levels of antiviral antibodies from either vaccinated or infected queens were protected from FIV inoculation. Kittens that received low levels of maternal antiviral antibodies were not completely protected from similar FIV inoculation. Protection correlated more closely with the level of maternal VN antibodies than the anti-p25 antibodies transferred to the kittens. The unprotected kittens born to infected queens were not infected from vertical transmission because all littermates that were not FIV-inoculated remained free of FIV infection.

CONCLUSIONS

Maternal antiviral antibodies, including VN antibodies, from either vaccinated or infected queens protected neonatal kittens from FIV inoculation. Thus, maternal antiviral antibodies play a key role in preventing or limiting infection in neonates and such antiviral immunity can be provided by vaccinated queens.

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Authors+Show Affiliations

Pu R
Department of Comparative and Experimental Pathology, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA.
Okada S
No affiliation info available
Little ER
No affiliation info available
Xu B
No affiliation info available
Stoffs WV
No affiliation info available
Yamamoto JK
No affiliation info available

MeSH

AnimalsAnimals, NewbornAntibodies, ViralBase SequenceCatsDNA, ViralFemaleImmunity, Maternally-AcquiredImmunodeficiency Virus, FelineInfectious Disease Transmission, VerticalLentivirus InfectionsMolecular Sequence DataNeutralization TestsSpecific Pathogen-Free OrganismsVaccinationViral ProteinsViral Vaccines

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7755911

Citation

Pu, R, et al. "Protection of Neonatal Kittens Against Feline Immunodeficiency Virus Infection With Passive Maternal Antiviral Antibodies." AIDS (London, England), vol. 9, no. 3, 1995, pp. 235-42.
Pu R, Okada S, Little ER, et al. Protection of neonatal kittens against feline immunodeficiency virus infection with passive maternal antiviral antibodies. AIDS. 1995;9(3):235-42.
Pu, R., Okada, S., Little, E. R., Xu, B., Stoffs, W. V., & Yamamoto, J. K. (1995). Protection of neonatal kittens against feline immunodeficiency virus infection with passive maternal antiviral antibodies. AIDS (London, England), 9(3), 235-42.
Pu R, et al. Protection of Neonatal Kittens Against Feline Immunodeficiency Virus Infection With Passive Maternal Antiviral Antibodies. AIDS. 1995;9(3):235-42. PubMed PMID: 7755911.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protection of neonatal kittens against feline immunodeficiency virus infection with passive maternal antiviral antibodies. AU - Pu,R, AU - Okada,S, AU - Little,E R, AU - Xu,B, AU - Stoffs,W V, AU - Yamamoto,J K, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 235 EP - 42 JF - AIDS (London, England) JO - AIDS VL - 9 IS - 3 N2 - OBJECTIVE: Maternal antibodies from either vaccinated or feline immunodeficiency virus (FIV)-infected female cats (queens) were evaluated for their ability to protect kittens against homologous FIV infection. DESIGN: Kittens that received different levels of maternal antiviral antibodies from either vaccinated or infected queens were inoculated with homologous FIV at 1 week post-parturition and monitored for FIV infection. Maternal antiviral antibodies in the kittens were also measured and compared to the level of FIV infection. METHODS: Kittens at 1 week post-parturition were inoculated intraperitoneally with five median cat infectious doses of FIVPet. FIV infection was monitored by virus isolation for infectious FIV and by nested polymerase chain reaction for proviral DNA. Virus-neutralizing (VN) antibodies and antibodies to FIV transmembrane peptide and core protein were also monitored throughout the 25 weeks. RESULTS: Neonatal kittens that received high levels of antiviral antibodies from either vaccinated or infected queens were protected from FIV inoculation. Kittens that received low levels of maternal antiviral antibodies were not completely protected from similar FIV inoculation. Protection correlated more closely with the level of maternal VN antibodies than the anti-p25 antibodies transferred to the kittens. The unprotected kittens born to infected queens were not infected from vertical transmission because all littermates that were not FIV-inoculated remained free of FIV infection. CONCLUSIONS: Maternal antiviral antibodies, including VN antibodies, from either vaccinated or infected queens protected neonatal kittens from FIV inoculation. Thus, maternal antiviral antibodies play a key role in preventing or limiting infection in neonates and such antiviral immunity can be provided by vaccinated queens. SN - 0269-9370 UR - https://www.unboundmedicine.com/medline/citation/7755911/Protection_of_neonatal_kittens_against_feline_immunodeficiency_virus_infection_with_passive_maternal_antiviral_antibodies_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=7755911.ui DB - PRIME DP - Unbound Medicine ER -