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Body composition and bone mineral density in untreated and treated patients with celiac disease.
Bone 1995; 16(2):231-4BONE

Abstract

Body composition and bone mineral density (BMD) were studied by X-ray absorptiometry in 20 untreated and 12 treated women with celiac disease, as well as in 85 age-matched control women. Untreated patients had a significantly lower body weight, fat mass, lean tissue mass and BMD at the lumbar spine and total skeleton compared to controls (p < 0.001 for all parameters). Treated patients had also a significantly lower body weight (p < 0.01) fat mass (p < 0.05) and bone mineral density at lumbar spine and total skeleton (p < 0.05) compared with controls, but lean tissue mass was not diminished. However, treated patients had a significantly higher body weight, fat mass and BMD of the total skeleton compared with untreated celiac patients (p < 0.01 for all parameters). Serum alkaline phosphatase levels were increased in untreated patients but serum 250HD was normal. In conclusion, celiac disease causes a global and almost universal reduction of fat mass and BMD. The results of this cross-sectional study suggest that osteopenia does not seem to be completely restored by adequate treatment. Alteration of vitamin D metabolism was not the cause of osteopenia in the majority of patients.

Authors+Show Affiliations

Sección Osteopatías Médicas, Hospital de Clínicas, Buenos Aires, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7756052

Citation

González, D, et al. "Body Composition and Bone Mineral Density in Untreated and Treated Patients With Celiac Disease." Bone, vol. 16, no. 2, 1995, pp. 231-4.
González D, Mazure R, Mautalen C, et al. Body composition and bone mineral density in untreated and treated patients with celiac disease. Bone. 1995;16(2):231-4.
González, D., Mazure, R., Mautalen, C., Vazquez, H., & Bai, J. (1995). Body composition and bone mineral density in untreated and treated patients with celiac disease. Bone, 16(2), pp. 231-4.
González D, et al. Body Composition and Bone Mineral Density in Untreated and Treated Patients With Celiac Disease. Bone. 1995;16(2):231-4. PubMed PMID: 7756052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body composition and bone mineral density in untreated and treated patients with celiac disease. AU - González,D, AU - Mazure,R, AU - Mautalen,C, AU - Vazquez,H, AU - Bai,J, PY - 1995/2/1/pubmed PY - 1995/2/1/medline PY - 1995/2/1/entrez SP - 231 EP - 4 JF - Bone JO - Bone VL - 16 IS - 2 N2 - Body composition and bone mineral density (BMD) were studied by X-ray absorptiometry in 20 untreated and 12 treated women with celiac disease, as well as in 85 age-matched control women. Untreated patients had a significantly lower body weight, fat mass, lean tissue mass and BMD at the lumbar spine and total skeleton compared to controls (p < 0.001 for all parameters). Treated patients had also a significantly lower body weight (p < 0.01) fat mass (p < 0.05) and bone mineral density at lumbar spine and total skeleton (p < 0.05) compared with controls, but lean tissue mass was not diminished. However, treated patients had a significantly higher body weight, fat mass and BMD of the total skeleton compared with untreated celiac patients (p < 0.01 for all parameters). Serum alkaline phosphatase levels were increased in untreated patients but serum 250HD was normal. In conclusion, celiac disease causes a global and almost universal reduction of fat mass and BMD. The results of this cross-sectional study suggest that osteopenia does not seem to be completely restored by adequate treatment. Alteration of vitamin D metabolism was not the cause of osteopenia in the majority of patients. SN - 8756-3282 UR - https://www.unboundmedicine.com/medline/citation/7756052/Body_composition_and_bone_mineral_density_in_untreated_and_treated_patients_with_celiac_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/875632829400034W DB - PRIME DP - Unbound Medicine ER -