Tags

Type your tag names separated by a space and hit enter

Validation of a noninvasive tension-time index of inspiratory muscles.
J Appl Physiol (1985). 1995 Feb; 78(2):646-53.JA

Abstract

The aim of this study was to validate a noninvasive tension-time index (TT) for all the inspiratory muscles estimated from the measurement of mouth occlusion pressure (P0.1), i.e., TT of inspiratory muscles (TTmus = PI/PImax x TI/TT, where PI is mean inspiratory pressure, PImax is maximal PI, TI is time of muscle contraction, and TT is total time of respiratory cycle) compared with TT of the diaphragm (TTdi = Pdi/Pdimax x TI/TT, where Pdi is mean transdiaphragmatic pressure and Pdimax is maximal Pdi). PI was estimated as PI = 5 P0.1 x TI. Eleven patients with chronic obstructive pulmonary disease and seven normal subjects were studied at rest in the sitting position. After 5 min of steady state, we measured breathing pattern, gastric and esophageal pressures, Pdi, mean inspiratory transpulmonary pressure swing, PImax, and Pdimax. By linear regression analysis, significant positive correlations were found between PI and mean inspiratory transpulmonary pressure swing, PI and Pdi, PImax and Pdimax, and PI/PImax and Pdi/Pdimax, with P < 0.001 for all subjects combined. These led to the highly significant correlation between TTmus and TTdi for all subjects combined (TTmus = 2.1 TTdi + 0.012; r = 0.97; P < 0.001) and for patients only (TTmus = 2.0 TTdi + 0.024; r = 0.97; P < 0.001). Therefore, patterns of breathing that lie near fatigue thresholds can be identified with TTmus or TTdi. In conclusion, noninvasive and clinically easily determined TTmus seems valid for situating patients of chronic obstructive pulmonary disease in reference to the inspiratory muscle fatigue.

Authors+Show Affiliations

Laboratoire de Physiologie des Interactions, Hôpital Arnaud de Villeneuve, Montpellier, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

7759435

Citation

Ramonatxo, M, et al. "Validation of a Noninvasive Tension-time Index of Inspiratory Muscles." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 78, no. 2, 1995, pp. 646-53.
Ramonatxo M, Boulard P, Préfaut C. Validation of a noninvasive tension-time index of inspiratory muscles. J Appl Physiol. 1995;78(2):646-53.
Ramonatxo, M., Boulard, P., & Préfaut, C. (1995). Validation of a noninvasive tension-time index of inspiratory muscles. Journal of Applied Physiology (Bethesda, Md. : 1985), 78(2), 646-53.
Ramonatxo M, Boulard P, Préfaut C. Validation of a Noninvasive Tension-time Index of Inspiratory Muscles. J Appl Physiol. 1995;78(2):646-53. PubMed PMID: 7759435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Validation of a noninvasive tension-time index of inspiratory muscles. AU - Ramonatxo,M, AU - Boulard,P, AU - Préfaut,C, PY - 1995/2/1/pubmed PY - 1995/2/1/medline PY - 1995/2/1/entrez SP - 646 EP - 53 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J. Appl. Physiol. VL - 78 IS - 2 N2 - The aim of this study was to validate a noninvasive tension-time index (TT) for all the inspiratory muscles estimated from the measurement of mouth occlusion pressure (P0.1), i.e., TT of inspiratory muscles (TTmus = PI/PImax x TI/TT, where PI is mean inspiratory pressure, PImax is maximal PI, TI is time of muscle contraction, and TT is total time of respiratory cycle) compared with TT of the diaphragm (TTdi = Pdi/Pdimax x TI/TT, where Pdi is mean transdiaphragmatic pressure and Pdimax is maximal Pdi). PI was estimated as PI = 5 P0.1 x TI. Eleven patients with chronic obstructive pulmonary disease and seven normal subjects were studied at rest in the sitting position. After 5 min of steady state, we measured breathing pattern, gastric and esophageal pressures, Pdi, mean inspiratory transpulmonary pressure swing, PImax, and Pdimax. By linear regression analysis, significant positive correlations were found between PI and mean inspiratory transpulmonary pressure swing, PI and Pdi, PImax and Pdimax, and PI/PImax and Pdi/Pdimax, with P < 0.001 for all subjects combined. These led to the highly significant correlation between TTmus and TTdi for all subjects combined (TTmus = 2.1 TTdi + 0.012; r = 0.97; P < 0.001) and for patients only (TTmus = 2.0 TTdi + 0.024; r = 0.97; P < 0.001). Therefore, patterns of breathing that lie near fatigue thresholds can be identified with TTmus or TTdi. In conclusion, noninvasive and clinically easily determined TTmus seems valid for situating patients of chronic obstructive pulmonary disease in reference to the inspiratory muscle fatigue. SN - 8750-7587 UR - https://www.unboundmedicine.com/medline/citation/7759435/Validation_of_a_noninvasive_tension_time_index_of_inspiratory_muscles_ L2 - http://www.physiology.org/doi/full/10.1152/jappl.1995.78.2.646?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -