Tags

Type your tag names separated by a space and hit enter

Dopamine inhibits the Na-K ATPase activity of the stria vascularis in the cochlea. In vivo ultracytochemical study.
Acta Otolaryngol. 1995 Jan; 115(1):27-30.AO

Abstract

It is believed that the function of the stria vascularis in the cochlea is to produce endolymph. However, the mechanisms that maintain and control the function of the stria vascularis remain unclear. In the present study, to clarify the role of humoral substances in the stria vascularis, a cerium-based method was used to investigate the ultracytochemical effects of intraperitoneal dopamine administration on ouabain-sensitive, K(+)-dependent, p-nitrophenylphosphatase (K-NPPase) activity, which is the second step in the formation of the Na-K ATPase complex, in the stria vascularis of guinea pigs. Na-K ATPase activity was shown to be completely inhibited after dopamine administration. This observation suggests that dopamine inhibits Na-K ATPase activity in the marginal cells of the stria vascularis, and that the stria vascularis may have dopamine receptors. Catecholamines may play an important role in the maintenance and/or control of stria vascularis function.

Authors+Show Affiliations

Department of Otolaryngology, Hyogo College of Medicine, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7762379

Citation

Kanoh, N. "Dopamine Inhibits the Na-K ATPase Activity of the Stria Vascularis in the Cochlea. in Vivo Ultracytochemical Study." Acta Oto-laryngologica, vol. 115, no. 1, 1995, pp. 27-30.
Kanoh N. Dopamine inhibits the Na-K ATPase activity of the stria vascularis in the cochlea. In vivo ultracytochemical study. Acta Otolaryngol. 1995;115(1):27-30.
Kanoh, N. (1995). Dopamine inhibits the Na-K ATPase activity of the stria vascularis in the cochlea. In vivo ultracytochemical study. Acta Oto-laryngologica, 115(1), 27-30.
Kanoh N. Dopamine Inhibits the Na-K ATPase Activity of the Stria Vascularis in the Cochlea. in Vivo Ultracytochemical Study. Acta Otolaryngol. 1995;115(1):27-30. PubMed PMID: 7762379.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dopamine inhibits the Na-K ATPase activity of the stria vascularis in the cochlea. In vivo ultracytochemical study. A1 - Kanoh,N, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 27 EP - 30 JF - Acta oto-laryngologica JO - Acta Otolaryngol VL - 115 IS - 1 N2 - It is believed that the function of the stria vascularis in the cochlea is to produce endolymph. However, the mechanisms that maintain and control the function of the stria vascularis remain unclear. In the present study, to clarify the role of humoral substances in the stria vascularis, a cerium-based method was used to investigate the ultracytochemical effects of intraperitoneal dopamine administration on ouabain-sensitive, K(+)-dependent, p-nitrophenylphosphatase (K-NPPase) activity, which is the second step in the formation of the Na-K ATPase complex, in the stria vascularis of guinea pigs. Na-K ATPase activity was shown to be completely inhibited after dopamine administration. This observation suggests that dopamine inhibits Na-K ATPase activity in the marginal cells of the stria vascularis, and that the stria vascularis may have dopamine receptors. Catecholamines may play an important role in the maintenance and/or control of stria vascularis function. SN - 0001-6489 UR - https://www.unboundmedicine.com/medline/citation/7762379/Dopamine_inhibits_the_Na_K_ATPase_activity_of_the_stria_vascularis_in_the_cochlea__In_vivo_ultracytochemical_study_ L2 - https://www.tandfonline.com/doi/full/10.3109/00016489509133341 DB - PRIME DP - Unbound Medicine ER -