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Antitumor active protein-containing glycans from the Chinese mushroom songshan lingzhi, Ganoderma tsugae mycelium.
Biosci Biotechnol Biochem. 1994 Jul; 58(7):1202-5.BB

Abstract

A water-soluble polysaccharide, FI, extracted from the mycelium of Granoderma tsugae, was fractionated and purified by ion-exchange chromatography, gel filtration, and affinity chromatography. Sixteen polysaccharides obtained were examined for antitumor effects on Sarcoma 180 in mice. The three active polysaccharides obtained were as follows: FIo-a: A glycan-protein complex containing 9.3% protein, and having a hetero-glyco-chain of mannose and xylose. FIo-b-alpha: Molecular weight 10,000, glucan-protein complex containing 25.8% protein. The inhibition ratio was 61.8% against the solid cancer Sarcoma 180/mice; the survival ratio was more than 194% of the control group (100). FA-1-b-alpha: Molecular weight 16,000, a complex of glycan:protein = 42:58 w/w, consisting of glucose as a main component, and associated with arabinose, mannose, xylose, and galactose. This had a tumor inhibition ratio of 56% and a survival ratio of more than 182%. Comparison of active glycan with the fruiting body and mycelium: Among water-soluble polysaccharides of fruiting body, FIo-a and FA-1, with antitumor activity, were both glucogalactan-protein complexes of molecular weight 10,000, but that of mycelium was a homoglucan protein complex in FIo-b-alpha and heteroglucan protein in both FA-1-a and FA-1-b-alpha. The heteroglucan had a low tumor inhibition ratio, but caused a high survival ratio in mice.

Authors+Show Affiliations

Department of Traditional Chinese Pharmacy, Changchun College of Traditional Chinese Medicine, Jilin.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

7765245

Citation

Zhang, J, et al. "Antitumor Active Protein-containing Glycans From the Chinese Mushroom Songshan Lingzhi, Ganoderma Tsugae Mycelium." Bioscience, Biotechnology, and Biochemistry, vol. 58, no. 7, 1994, pp. 1202-5.
Zhang J, Wang G, Li H, et al. Antitumor active protein-containing glycans from the Chinese mushroom songshan lingzhi, Ganoderma tsugae mycelium. Biosci Biotechnol Biochem. 1994;58(7):1202-5.
Zhang, J., Wang, G., Li, H., Zhuang, C., Mizuno, T., Ito, H., Mayuzumi, H., Okamoto, H., & Li, J. (1994). Antitumor active protein-containing glycans from the Chinese mushroom songshan lingzhi, Ganoderma tsugae mycelium. Bioscience, Biotechnology, and Biochemistry, 58(7), 1202-5.
Zhang J, et al. Antitumor Active Protein-containing Glycans From the Chinese Mushroom Songshan Lingzhi, Ganoderma Tsugae Mycelium. Biosci Biotechnol Biochem. 1994;58(7):1202-5. PubMed PMID: 7765245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antitumor active protein-containing glycans from the Chinese mushroom songshan lingzhi, Ganoderma tsugae mycelium. AU - Zhang,J, AU - Wang,G, AU - Li,H, AU - Zhuang,C, AU - Mizuno,T, AU - Ito,H, AU - Mayuzumi,H, AU - Okamoto,H, AU - Li,J, PY - 1994/7/1/pubmed PY - 1994/7/1/medline PY - 1994/7/1/entrez SP - 1202 EP - 5 JF - Bioscience, biotechnology, and biochemistry JO - Biosci Biotechnol Biochem VL - 58 IS - 7 N2 - A water-soluble polysaccharide, FI, extracted from the mycelium of Granoderma tsugae, was fractionated and purified by ion-exchange chromatography, gel filtration, and affinity chromatography. Sixteen polysaccharides obtained were examined for antitumor effects on Sarcoma 180 in mice. The three active polysaccharides obtained were as follows: FIo-a: A glycan-protein complex containing 9.3% protein, and having a hetero-glyco-chain of mannose and xylose. FIo-b-alpha: Molecular weight 10,000, glucan-protein complex containing 25.8% protein. The inhibition ratio was 61.8% against the solid cancer Sarcoma 180/mice; the survival ratio was more than 194% of the control group (100). FA-1-b-alpha: Molecular weight 16,000, a complex of glycan:protein = 42:58 w/w, consisting of glucose as a main component, and associated with arabinose, mannose, xylose, and galactose. This had a tumor inhibition ratio of 56% and a survival ratio of more than 182%. Comparison of active glycan with the fruiting body and mycelium: Among water-soluble polysaccharides of fruiting body, FIo-a and FA-1, with antitumor activity, were both glucogalactan-protein complexes of molecular weight 10,000, but that of mycelium was a homoglucan protein complex in FIo-b-alpha and heteroglucan protein in both FA-1-a and FA-1-b-alpha. The heteroglucan had a low tumor inhibition ratio, but caused a high survival ratio in mice. SN - 0916-8451 UR - https://www.unboundmedicine.com/medline/citation/7765245/Antitumor_active_protein_containing_glycans_from_the_Chinese_mushroom_songshan_lingzhi_Ganoderma_tsugae_mycelium_ L2 - https://joi.jlc.jst.go.jp/JST.Journalarchive/bbb1992/58.1202?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -