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Selenoprotein P and glutathione peroxidase (EC 1.11.1.9) in plasma as indices of selenium status in relation to the intake of fish.
Br J Nutr 1995; 73(3):455-61BJ

Abstract

In Sweden fish is considered to be an important source of dietary Se. Therefore Se status was assessed in forty-one middle-aged men with widely varying fish consumption. Glutathione peroxidase (EC 1.11.1.9) and selenoprotein P in plasma were measured by radioimmunoassay. Plasma Se among the men increased slightly with increasing consumption of fish, but no such increases in the concentrations of glutathione peroxidase and selenoprotein P in plasma were observed. Moreover, no correlation was found between plasma Se and glutathione peroxidase or selenoprotein P. Instead, glutathione peroxidase was significantly correlated with selenoprotein P (r 0.73, P < 0.001), indicating that both glutathione peroxidase and selenoprotein P were functional indicators of Se status in this group. The proportion of plasma Se located in glutathione peroxidase decreased with increasing plasma Se. The results suggest that the Se consumed from fish had no apparent effect on the amount of Se incorporated into the functional selenoproteins of plasma. It is concluded that in some cases selenoproteins may be better biological markers of Se status than the total concentration of Se.

Authors+Show Affiliations

Department of Applied Nutrition and Food Chemistry, University of Lund, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7766568

Citation

Huang, W, et al. "Selenoprotein P and Glutathione Peroxidase (EC 1.11.1.9) in Plasma as Indices of Selenium Status in Relation to the Intake of Fish." The British Journal of Nutrition, vol. 73, no. 3, 1995, pp. 455-61.
Huang W, Akesson B, Svensson BG, et al. Selenoprotein P and glutathione peroxidase (EC 1.11.1.9) in plasma as indices of selenium status in relation to the intake of fish. Br J Nutr. 1995;73(3):455-61.
Huang, W., Akesson, B., Svensson, B. G., Schütz, A., Burk, R. F., & Skerfving, S. (1995). Selenoprotein P and glutathione peroxidase (EC 1.11.1.9) in plasma as indices of selenium status in relation to the intake of fish. The British Journal of Nutrition, 73(3), pp. 455-61.
Huang W, et al. Selenoprotein P and Glutathione Peroxidase (EC 1.11.1.9) in Plasma as Indices of Selenium Status in Relation to the Intake of Fish. Br J Nutr. 1995;73(3):455-61. PubMed PMID: 7766568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenoprotein P and glutathione peroxidase (EC 1.11.1.9) in plasma as indices of selenium status in relation to the intake of fish. AU - Huang,W, AU - Akesson,B, AU - Svensson,B G, AU - Schütz,A, AU - Burk,R F, AU - Skerfving,S, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 455 EP - 61 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 73 IS - 3 N2 - In Sweden fish is considered to be an important source of dietary Se. Therefore Se status was assessed in forty-one middle-aged men with widely varying fish consumption. Glutathione peroxidase (EC 1.11.1.9) and selenoprotein P in plasma were measured by radioimmunoassay. Plasma Se among the men increased slightly with increasing consumption of fish, but no such increases in the concentrations of glutathione peroxidase and selenoprotein P in plasma were observed. Moreover, no correlation was found between plasma Se and glutathione peroxidase or selenoprotein P. Instead, glutathione peroxidase was significantly correlated with selenoprotein P (r 0.73, P < 0.001), indicating that both glutathione peroxidase and selenoprotein P were functional indicators of Se status in this group. The proportion of plasma Se located in glutathione peroxidase decreased with increasing plasma Se. The results suggest that the Se consumed from fish had no apparent effect on the amount of Se incorporated into the functional selenoproteins of plasma. It is concluded that in some cases selenoproteins may be better biological markers of Se status than the total concentration of Se. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/7766568/Selenoprotein_P_and_glutathione_peroxidase__EC_1_11_1_9__in_plasma_as_indices_of_selenium_status_in_relation_to_the_intake_of_fish_ L2 - https://www.cambridge.org/core/product/identifier/S0007114595000481/type/journal_article DB - PRIME DP - Unbound Medicine ER -