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Analysis of glucose and insulin mass transfer in a novel 2-channel bioartificial pancreas.

Abstract

This paper introduces a newly developed 2-channel bioartificial pancreas for the treatment of type I diabetes. In this device, insulin secreting cells (islets of Langerhans) are placed between 2 semi-permeable membranes that form a flat rectangular chamber. One side of the chamber is in contact with blood from an artery and the other side with blood from a vein. In addition to the diffusive transfer of glucose and insulin, the pressure difference between the artery and the vein creates an ultrafiltration flux through the islet chamber. This diffusion and ultrafiltration flux carries glucose from the artery to the islets, and insulin from the islets to the vein. The bioartificial pancreas has a compact geometry and the blood channels were designed to prevent blood clotting. The predicted insulin release in response to a square-wave and a triangular-wave glucose stimulation is given for the bioartificial pancreas of dimensions necessary for implantation in diabetic patients.

Authors+Show Affiliations

Johns Hopkins University, Department of Mechanical Engineering, Baltimore, MD 21218-2686, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7767439

Citation

Moussy, Y, and F Moussy. "Analysis of Glucose and Insulin Mass Transfer in a Novel 2-channel Bioartificial Pancreas." Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, vol. 23, no. 2, 1995, pp. 163-73.
Moussy Y, Moussy F. Analysis of glucose and insulin mass transfer in a novel 2-channel bioartificial pancreas. Artif Cells Blood Substit Immobil Biotechnol. 1995;23(2):163-73.
Moussy, Y., & Moussy, F. (1995). Analysis of glucose and insulin mass transfer in a novel 2-channel bioartificial pancreas. Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, 23(2), 163-73.
Moussy Y, Moussy F. Analysis of Glucose and Insulin Mass Transfer in a Novel 2-channel Bioartificial Pancreas. Artif Cells Blood Substit Immobil Biotechnol. 1995;23(2):163-73. PubMed PMID: 7767439.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of glucose and insulin mass transfer in a novel 2-channel bioartificial pancreas. AU - Moussy,Y, AU - Moussy,F, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 163 EP - 73 JF - Artificial cells, blood substitutes, and immobilization biotechnology JO - Artif Cells Blood Substit Immobil Biotechnol VL - 23 IS - 2 N2 - This paper introduces a newly developed 2-channel bioartificial pancreas for the treatment of type I diabetes. In this device, insulin secreting cells (islets of Langerhans) are placed between 2 semi-permeable membranes that form a flat rectangular chamber. One side of the chamber is in contact with blood from an artery and the other side with blood from a vein. In addition to the diffusive transfer of glucose and insulin, the pressure difference between the artery and the vein creates an ultrafiltration flux through the islet chamber. This diffusion and ultrafiltration flux carries glucose from the artery to the islets, and insulin from the islets to the vein. The bioartificial pancreas has a compact geometry and the blood channels were designed to prevent blood clotting. The predicted insulin release in response to a square-wave and a triangular-wave glucose stimulation is given for the bioartificial pancreas of dimensions necessary for implantation in diabetic patients. SN - 1073-1199 UR - https://www.unboundmedicine.com/medline/citation/7767439/Analysis_of_glucose_and_insulin_mass_transfer_in_a_novel_2_channel_bioartificial_pancreas_ L2 - https://www.tandfonline.com/doi/full/10.3109/10731199509117936 DB - PRIME DP - Unbound Medicine ER -