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Humoral hypercalcemia of malignancy: some enigmas on the clinical features.
J Cell Biochem. 1995 Mar; 57(3):384-91.JC

Abstract

Humoral hypercalcemia of malignancy (HHM) is a common paraneoplastic syndrome mediated by tumor-derived parathyroid hormone-related peptide (PTHRP), which bears structural and functional similarities to PTH. Thus the clinical features of HHM are very similar to those of primary hyperparathyroidism (1 degree HPT), a prototype of humoral hypercalcemia caused by PTH. On the other hand, HHM syndrome differs from 1 degree HPT in several aspects, including serum 1,25(OH)2D levels, acid-base balance, and bone remodeling process, the reason of which remains largely unknown. We approached these questions using a unique animal model of HHM, nude rats implanted with PTHRP-overproducing human carcinomas. In this review we will summarize the results and discuss the implications in understanding the disease mechanism.

Authors+Show Affiliations

Ikeda K
Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan.
Ogata E
No affiliation info available

MeSH

AnimalsHumansHypercalcemiaNeoplasm ProteinsNeoplasmsNeoplasms, ExperimentalParaneoplastic SyndromesParathyroid HormoneParathyroid Hormone-Related ProteinProtein Structure, TertiaryProteinsRats

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

7768974

Citation

Ikeda, K, and E Ogata. "Humoral Hypercalcemia of Malignancy: some Enigmas On the Clinical Features." Journal of Cellular Biochemistry, vol. 57, no. 3, 1995, pp. 384-91.
Ikeda K, Ogata E. Humoral hypercalcemia of malignancy: some enigmas on the clinical features. J Cell Biochem. 1995;57(3):384-91.
Ikeda, K., & Ogata, E. (1995). Humoral hypercalcemia of malignancy: some enigmas on the clinical features. Journal of Cellular Biochemistry, 57(3), 384-91.
Ikeda K, Ogata E. Humoral Hypercalcemia of Malignancy: some Enigmas On the Clinical Features. J Cell Biochem. 1995;57(3):384-91. PubMed PMID: 7768974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Humoral hypercalcemia of malignancy: some enigmas on the clinical features. AU - Ikeda,K, AU - Ogata,E, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 384 EP - 91 JF - Journal of cellular biochemistry JO - J Cell Biochem VL - 57 IS - 3 N2 - Humoral hypercalcemia of malignancy (HHM) is a common paraneoplastic syndrome mediated by tumor-derived parathyroid hormone-related peptide (PTHRP), which bears structural and functional similarities to PTH. Thus the clinical features of HHM are very similar to those of primary hyperparathyroidism (1 degree HPT), a prototype of humoral hypercalcemia caused by PTH. On the other hand, HHM syndrome differs from 1 degree HPT in several aspects, including serum 1,25(OH)2D levels, acid-base balance, and bone remodeling process, the reason of which remains largely unknown. We approached these questions using a unique animal model of HHM, nude rats implanted with PTHRP-overproducing human carcinomas. In this review we will summarize the results and discuss the implications in understanding the disease mechanism. SN - 0730-2312 UR - https://www.unboundmedicine.com/medline/citation/7768974/Humoral_hypercalcemia_of_malignancy:_some_enigmas_on_the_clinical_features_ L2 - https://doi.org/10.1002/jcb.240570303 DB - PRIME DP - Unbound Medicine ER -