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Antitumor-active heteroglycans from niohshimeji mushroom, Tricholoma giganteum.
Biosci Biotechnol Biochem. 1995 Apr; 59(4):568-71.BB

Abstract

Water-soluble polysaccharide FI and water-insoluble polysaccharides FII, FIII-1, and FIII-2 were obtained from fruiting bodies of Tricholoma giganteum. Polysaccharides were further fractionated by ion-exchange chromatography, gel filtration, and affinity chromatography. The 24 polysaccharide fractions obtained were examined for their antitumor effect on Sarcoma 180 implanted in mice. The following antitumor-active polysaccharides were identified: FIo-a, a mixture of alpha-D-glucan and xyloglucomannan with an average molecular weight of 1.6 x 10(6); FA-1, a beta-D-glucan containing 1% protein and with a molecular weight of 4.0 x 10(4); FII-1, a (1-->3)-beta-D-glucan containing 7.8% protein, with a molecular weight of 5.2 x 10(4); FIII-1-b, a protein-polysaccharide complex (ratio, 37.5:62.5, w/w), with a molecular weight of 6.8 x 10(4) and with xylose, galactose, mannose, and glucose in the polysaccharide moiety (proportions of 8.9:14.9:29.3:46.9 by weight), and FIII-2-a, b, and c, three (1-->6)-beta-D-glucosyl-branched (1-->3)-beta-D-glucans with a molecular weight from 2.6 x 10(5) to 4.1 x 10(5) and containing small amounts of xylose and galactose and 3.5-8.3% protein.

Authors+Show Affiliations

Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7772819

Citation

Mizuno, T, et al. "Antitumor-active Heteroglycans From Niohshimeji Mushroom, Tricholoma Giganteum." Bioscience, Biotechnology, and Biochemistry, vol. 59, no. 4, 1995, pp. 568-71.
Mizuno T, Kinoshita T, Zhuang C, et al. Antitumor-active heteroglycans from niohshimeji mushroom, Tricholoma giganteum. Biosci Biotechnol Biochem. 1995;59(4):568-71.
Mizuno, T., Kinoshita, T., Zhuang, C., Ito, H., & Mayuzumi, Y. (1995). Antitumor-active heteroglycans from niohshimeji mushroom, Tricholoma giganteum. Bioscience, Biotechnology, and Biochemistry, 59(4), 568-71.
Mizuno T, et al. Antitumor-active Heteroglycans From Niohshimeji Mushroom, Tricholoma Giganteum. Biosci Biotechnol Biochem. 1995;59(4):568-71. PubMed PMID: 7772819.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antitumor-active heteroglycans from niohshimeji mushroom, Tricholoma giganteum. AU - Mizuno,T, AU - Kinoshita,T, AU - Zhuang,C, AU - Ito,H, AU - Mayuzumi,Y, PY - 1995/4/1/pubmed PY - 1995/4/1/medline PY - 1995/4/1/entrez SP - 568 EP - 71 JF - Bioscience, biotechnology, and biochemistry JO - Biosci Biotechnol Biochem VL - 59 IS - 4 N2 - Water-soluble polysaccharide FI and water-insoluble polysaccharides FII, FIII-1, and FIII-2 were obtained from fruiting bodies of Tricholoma giganteum. Polysaccharides were further fractionated by ion-exchange chromatography, gel filtration, and affinity chromatography. The 24 polysaccharide fractions obtained were examined for their antitumor effect on Sarcoma 180 implanted in mice. The following antitumor-active polysaccharides were identified: FIo-a, a mixture of alpha-D-glucan and xyloglucomannan with an average molecular weight of 1.6 x 10(6); FA-1, a beta-D-glucan containing 1% protein and with a molecular weight of 4.0 x 10(4); FII-1, a (1-->3)-beta-D-glucan containing 7.8% protein, with a molecular weight of 5.2 x 10(4); FIII-1-b, a protein-polysaccharide complex (ratio, 37.5:62.5, w/w), with a molecular weight of 6.8 x 10(4) and with xylose, galactose, mannose, and glucose in the polysaccharide moiety (proportions of 8.9:14.9:29.3:46.9 by weight), and FIII-2-a, b, and c, three (1-->6)-beta-D-glucosyl-branched (1-->3)-beta-D-glucans with a molecular weight from 2.6 x 10(5) to 4.1 x 10(5) and containing small amounts of xylose and galactose and 3.5-8.3% protein. SN - 0916-8451 UR - https://www.unboundmedicine.com/medline/citation/7772819/Antitumor_active_heteroglycans_from_niohshimeji_mushroom_Tricholoma_giganteum_ DB - PRIME DP - Unbound Medicine ER -