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Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function.
Eur J Clin Nutr. 1995 Mar; 49(3):169-78.EJ

Abstract

OBJECTIVE

To compare the effects of supplementing a low fat diet with an alpha-linolenic acid-rich (C18:3 n-3) oil with a linoleic acid-rich (C18:2 n-6) oil on platelet composition and function.

DESIGN

Prospective study with random allocation to one of the two oils.

SETTING

Free-living study.

SUBJECTS

Eleven healthy young males recruited from within the University.

INTERVENTIONS

Subjects were allocated to consume 40 g of either flaxseed oil (n = 5) or sunflowerseed oil (n = 6) daily for 23 days. Fasting blood samples were collected at commencement and completion of supplementation for analysis of platelet fatty acids and platelet aggregation.

RESULTS

The platelet eicosapentaenoic acid (EPA) more than doubled in the group taking flaxseed oil (P < 0.05) but was unchanged in the sunflowerseed group. As a result the platelet EPA:arachidonic acid ratio, considered a marker for thromboxane production and platelet aggregation potential, increased in the flaxseed group (P < 0.05). The aggregation response induced by 0.75 and 2 micrograms of collagen was decreased in those taking flaxseed oil (P < 0.05).

CONCLUSION

This study provides further evidence that consumption of alpha-linolenic acid-rich oils may offer protective effects against cardiovascular disease over linoleic acid-rich oils via their ability to decrease the tendency of platelets to aggregate.

Authors+Show Affiliations

Department of Biochemistry, University of Sydney, Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7774533

Citation

Allman, M A., et al. "Supplementation With Flaxseed Oil Versus Sunflowerseed Oil in Healthy Young Men Consuming a Low Fat Diet: Effects On Platelet Composition and Function." European Journal of Clinical Nutrition, vol. 49, no. 3, 1995, pp. 169-78.
Allman MA, Pena MM, Pang D. Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Eur J Clin Nutr. 1995;49(3):169-78.
Allman, M. A., Pena, M. M., & Pang, D. (1995). Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. European Journal of Clinical Nutrition, 49(3), 169-78.
Allman MA, Pena MM, Pang D. Supplementation With Flaxseed Oil Versus Sunflowerseed Oil in Healthy Young Men Consuming a Low Fat Diet: Effects On Platelet Composition and Function. Eur J Clin Nutr. 1995;49(3):169-78. PubMed PMID: 7774533.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. AU - Allman,M A, AU - Pena,M M, AU - Pang,D, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 169 EP - 78 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 49 IS - 3 N2 - OBJECTIVE: To compare the effects of supplementing a low fat diet with an alpha-linolenic acid-rich (C18:3 n-3) oil with a linoleic acid-rich (C18:2 n-6) oil on platelet composition and function. DESIGN: Prospective study with random allocation to one of the two oils. SETTING: Free-living study. SUBJECTS: Eleven healthy young males recruited from within the University. INTERVENTIONS: Subjects were allocated to consume 40 g of either flaxseed oil (n = 5) or sunflowerseed oil (n = 6) daily for 23 days. Fasting blood samples were collected at commencement and completion of supplementation for analysis of platelet fatty acids and platelet aggregation. RESULTS: The platelet eicosapentaenoic acid (EPA) more than doubled in the group taking flaxseed oil (P < 0.05) but was unchanged in the sunflowerseed group. As a result the platelet EPA:arachidonic acid ratio, considered a marker for thromboxane production and platelet aggregation potential, increased in the flaxseed group (P < 0.05). The aggregation response induced by 0.75 and 2 micrograms of collagen was decreased in those taking flaxseed oil (P < 0.05). CONCLUSION: This study provides further evidence that consumption of alpha-linolenic acid-rich oils may offer protective effects against cardiovascular disease over linoleic acid-rich oils via their ability to decrease the tendency of platelets to aggregate. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/7774533/Supplementation_with_flaxseed_oil_versus_sunflowerseed_oil_in_healthy_young_men_consuming_a_low_fat_diet:_effects_on_platelet_composition_and_function_ DB - PRIME DP - Unbound Medicine ER -