Tags

Type your tag names separated by a space and hit enter

T2/3 vulva cancer: a case-control study of triple incision versus en bloc radical vulvectomy and inguinal lymphadenectomy.
Gynecol Oncol. 1995 Jun; 57(3):335-9.GO

Abstract

The purpose of this case-control study was to compare outcome in T2/3 vulvar cancer patients treated with radical vulvectomy and inguinal lymphadenectomy using either a triple incision or en bloc technique. All T2/3 vulvar cancer patients treated by the triple incision technique were identified and compared to a control group consisting of similar T2/3 patients treated with an en bloc procedure at the same institution. Survival by surgical stage, lesion diameter, nodal status, and margin status was analyzed and compared between the two groups. Twenty-seven vulvar cancer patients with a T2/3 lesion underwent radical vulvectomy and inguinal lymphadenectomy using the triple incision technique; the control group consisted of 20 T2/3 vulvar cancer patients treated by en bloc resection. The two groups were matched for age, surgical stage, grade, lesion diameter, margin status, nodal status, and adjuvant treatment. The recurrence rate in the triple incision group was 37% compared to 35% in the en bloc group. (OR, 1.092, 95% CI, [0.327, 3.649], P = 0.9). There was no difference in the local recurrence rate between the two groups (80% in the triple incision group and 72% in the en bloc group) (P = 0.5). Five-year survival for the triple incision and the en bloc groups was similar, 64 and 82%, respectively (P = 0.15). Survival between the groups was not statistically different when analyzed according to surgical stage, lesion diameter, nodal status, and negative margin status. These data indicate that the triple incision technique provides survival outcomes similar to the standard en bloc radical vulvectomy in patients with T2/3 vulva cancer. Due to the significant morbidity that has been associated with the en bloc radical vulvectomy and inguinal lymphadenectomy, the triple incision technique should be considered as the preferred method of treatment for most vulvar cancer patients.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University of Alabama at Birmingham 35233-7333, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

7774837

Citation

Siller, B S., et al. "T2/3 Vulva Cancer: a Case-control Study of Triple Incision Versus En Bloc Radical Vulvectomy and Inguinal Lymphadenectomy." Gynecologic Oncology, vol. 57, no. 3, 1995, pp. 335-9.
Siller BS, Alvarez RD, Conner WD, et al. T2/3 vulva cancer: a case-control study of triple incision versus en bloc radical vulvectomy and inguinal lymphadenectomy. Gynecol Oncol. 1995;57(3):335-9.
Siller, B. S., Alvarez, R. D., Conner, W. D., McCullough, C. H., Kilgore, L. C., Partridge, E. E., & Austin, J. M. (1995). T2/3 vulva cancer: a case-control study of triple incision versus en bloc radical vulvectomy and inguinal lymphadenectomy. Gynecologic Oncology, 57(3), 335-9.
Siller BS, et al. T2/3 Vulva Cancer: a Case-control Study of Triple Incision Versus En Bloc Radical Vulvectomy and Inguinal Lymphadenectomy. Gynecol Oncol. 1995;57(3):335-9. PubMed PMID: 7774837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - T2/3 vulva cancer: a case-control study of triple incision versus en bloc radical vulvectomy and inguinal lymphadenectomy. AU - Siller,B S, AU - Alvarez,R D, AU - Conner,W D, AU - McCullough,C H, AU - Kilgore,L C, AU - Partridge,E E, AU - Austin,J M, PY - 1995/6/1/pubmed PY - 1995/6/1/medline PY - 1995/6/1/entrez SP - 335 EP - 9 JF - Gynecologic oncology JO - Gynecol Oncol VL - 57 IS - 3 N2 - The purpose of this case-control study was to compare outcome in T2/3 vulvar cancer patients treated with radical vulvectomy and inguinal lymphadenectomy using either a triple incision or en bloc technique. All T2/3 vulvar cancer patients treated by the triple incision technique were identified and compared to a control group consisting of similar T2/3 patients treated with an en bloc procedure at the same institution. Survival by surgical stage, lesion diameter, nodal status, and margin status was analyzed and compared between the two groups. Twenty-seven vulvar cancer patients with a T2/3 lesion underwent radical vulvectomy and inguinal lymphadenectomy using the triple incision technique; the control group consisted of 20 T2/3 vulvar cancer patients treated by en bloc resection. The two groups were matched for age, surgical stage, grade, lesion diameter, margin status, nodal status, and adjuvant treatment. The recurrence rate in the triple incision group was 37% compared to 35% in the en bloc group. (OR, 1.092, 95% CI, [0.327, 3.649], P = 0.9). There was no difference in the local recurrence rate between the two groups (80% in the triple incision group and 72% in the en bloc group) (P = 0.5). Five-year survival for the triple incision and the en bloc groups was similar, 64 and 82%, respectively (P = 0.15). Survival between the groups was not statistically different when analyzed according to surgical stage, lesion diameter, nodal status, and negative margin status. These data indicate that the triple incision technique provides survival outcomes similar to the standard en bloc radical vulvectomy in patients with T2/3 vulva cancer. Due to the significant morbidity that has been associated with the en bloc radical vulvectomy and inguinal lymphadenectomy, the triple incision technique should be considered as the preferred method of treatment for most vulvar cancer patients. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/7774837/T2/3_vulva_cancer:_a_case_control_study_of_triple_incision_versus_en_bloc_radical_vulvectomy_and_inguinal_lymphadenectomy_ DB - PRIME DP - Unbound Medicine ER -