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Successful liver treatment of a juvenile granulosa cell tumor in a 4-year-old child by regional deep hyperthermia, systemic chemotherapy, and irradiation.
Gynecol Oncol. 1995 Jun; 57(3):417-22.GO

Abstract

Juvenile granulosa cell tumors (JGCT) of the ovary are rare in children and adolescents. About 90% are diagnosed in early-stage FIGO I with favorable prognosis. More advanced stages (FIGO II-IV) have a poor clinical outcome and chemotherapy alone cannot avoid tumor progression. Regional deep hyperthermia (RHT) induced by microwave technique has been established as an additional modality for treatment of different tumors. However, in cases with liver involvement there are technical problems which have not yet been solved. We report on a 4-year-old child who suffered from diffuse liver metastases 10 months after JGCT of the left ovary. After chemotherapy including ifosfamide, etoposide, and carboplatin in combination with RHT and consolidation radiotherapy, the patient has been in complete remission for 1 year of follow-up. This Case Report indicates the feasibility of combining surgery, chemotherapy, hyperthermia, and radiation therapy (which can also be an effective treatment modality for advanced granulosa cell tumor) for the treatment of liver metastases of JGCT, but does not allow comparisons of these treatments.

Authors+Show Affiliations

Department of Pediatrics, Heinrich-Heine University, Düsseldorf, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7774848

Citation

Wessalowski, R, et al. "Successful Liver Treatment of a Juvenile Granulosa Cell Tumor in a 4-year-old Child By Regional Deep Hyperthermia, Systemic Chemotherapy, and Irradiation." Gynecologic Oncology, vol. 57, no. 3, 1995, pp. 417-22.
Wessalowski R, Spaar HJ, Pape H, et al. Successful liver treatment of a juvenile granulosa cell tumor in a 4-year-old child by regional deep hyperthermia, systemic chemotherapy, and irradiation. Gynecol Oncol. 1995;57(3):417-22.
Wessalowski, R., Spaar, H. J., Pape, H., Willers, R., Harms, D., & Göbel, U. (1995). Successful liver treatment of a juvenile granulosa cell tumor in a 4-year-old child by regional deep hyperthermia, systemic chemotherapy, and irradiation. Gynecologic Oncology, 57(3), 417-22.
Wessalowski R, et al. Successful Liver Treatment of a Juvenile Granulosa Cell Tumor in a 4-year-old Child By Regional Deep Hyperthermia, Systemic Chemotherapy, and Irradiation. Gynecol Oncol. 1995;57(3):417-22. PubMed PMID: 7774848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Successful liver treatment of a juvenile granulosa cell tumor in a 4-year-old child by regional deep hyperthermia, systemic chemotherapy, and irradiation. AU - Wessalowski,R, AU - Spaar,H J, AU - Pape,H, AU - Willers,R, AU - Harms,D, AU - Göbel,U, PY - 1995/6/1/pubmed PY - 1995/6/1/medline PY - 1995/6/1/entrez SP - 417 EP - 22 JF - Gynecologic oncology JO - Gynecol. Oncol. VL - 57 IS - 3 N2 - Juvenile granulosa cell tumors (JGCT) of the ovary are rare in children and adolescents. About 90% are diagnosed in early-stage FIGO I with favorable prognosis. More advanced stages (FIGO II-IV) have a poor clinical outcome and chemotherapy alone cannot avoid tumor progression. Regional deep hyperthermia (RHT) induced by microwave technique has been established as an additional modality for treatment of different tumors. However, in cases with liver involvement there are technical problems which have not yet been solved. We report on a 4-year-old child who suffered from diffuse liver metastases 10 months after JGCT of the left ovary. After chemotherapy including ifosfamide, etoposide, and carboplatin in combination with RHT and consolidation radiotherapy, the patient has been in complete remission for 1 year of follow-up. This Case Report indicates the feasibility of combining surgery, chemotherapy, hyperthermia, and radiation therapy (which can also be an effective treatment modality for advanced granulosa cell tumor) for the treatment of liver metastases of JGCT, but does not allow comparisons of these treatments. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/7774848/Successful_liver_treatment_of_a_juvenile_granulosa_cell_tumor_in_a_4_year_old_child_by_regional_deep_hyperthermia_systemic_chemotherapy_and_irradiation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(85)71165-1 DB - PRIME DP - Unbound Medicine ER -