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Ionized serum magnesium and potassium levels in pregnant women with preeclampsia and eclampsia.
J Reprod Med. 1995 Mar; 40(3):201-8.JR

Abstract

A prospective, cross-sectional study was performed to determine whether patients with preeclampsia or eclampsia had difficult serum levels or fractions of the active, ionized form of magnesium (IMg2+) as compared to normal, pregnant women. Using a novel ion selective electrode, we determined the IMg2+ levels and fractions as well as ionized calcium, sodium and potassium (K) in venous serum drawn on admission from 33 normal, pregnant women; 12 women with preeclampsia; and 2 women with postpartum eclampsia. Levels in 42 nonpregnant, age-matched, healthy women were also measured. We found that in normal pregnancy, levels and fractions of IMg2+ were significantly decreased as compared to levels and fractions in nonpregnant women (0.48 +/- 0.01 [SE] versus 0.60 +/- 0.005 mmol/L, and 63.2 +/- 1.0% versus 71.6 +/- 0.6%; P < .001 for both), but the levels and fractions in preeclamptics (0.48 +/- 0.01 mmol/L and 64.2 +/- 1.7%) were not significantly different (P > .05) from those in normal, pregnant women. Similarly, the levels and fractions of IMg2+ in the two eclamptic patients were within the ranges of normal and preeclamptic pregnancies. When the other cations were analyzed, a highly significant elevation (P < .001) in the mean K+ level and the K+/IMg2+ ratio in the preeclamptic patients was noted. Thus, it appears that serum IMg2+ levels are maintained in preeclampsia and eclampsia, but disturbances in K homeostasis and in the interrelationships between K and IMg2+ may occur.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, New York Hospital Medical Center of Queens, Flushing, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

7776305

Citation

Handwerker, S M., et al. "Ionized Serum Magnesium and Potassium Levels in Pregnant Women With Preeclampsia and Eclampsia." The Journal of Reproductive Medicine, vol. 40, no. 3, 1995, pp. 201-8.
Handwerker SM, Altura BT, Altura BM. Ionized serum magnesium and potassium levels in pregnant women with preeclampsia and eclampsia. J Reprod Med. 1995;40(3):201-8.
Handwerker, S. M., Altura, B. T., & Altura, B. M. (1995). Ionized serum magnesium and potassium levels in pregnant women with preeclampsia and eclampsia. The Journal of Reproductive Medicine, 40(3), 201-8.
Handwerker SM, Altura BT, Altura BM. Ionized Serum Magnesium and Potassium Levels in Pregnant Women With Preeclampsia and Eclampsia. J Reprod Med. 1995;40(3):201-8. PubMed PMID: 7776305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ionized serum magnesium and potassium levels in pregnant women with preeclampsia and eclampsia. AU - Handwerker,S M, AU - Altura,B T, AU - Altura,B M, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 201 EP - 8 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 40 IS - 3 N2 - A prospective, cross-sectional study was performed to determine whether patients with preeclampsia or eclampsia had difficult serum levels or fractions of the active, ionized form of magnesium (IMg2+) as compared to normal, pregnant women. Using a novel ion selective electrode, we determined the IMg2+ levels and fractions as well as ionized calcium, sodium and potassium (K) in venous serum drawn on admission from 33 normal, pregnant women; 12 women with preeclampsia; and 2 women with postpartum eclampsia. Levels in 42 nonpregnant, age-matched, healthy women were also measured. We found that in normal pregnancy, levels and fractions of IMg2+ were significantly decreased as compared to levels and fractions in nonpregnant women (0.48 +/- 0.01 [SE] versus 0.60 +/- 0.005 mmol/L, and 63.2 +/- 1.0% versus 71.6 +/- 0.6%; P < .001 for both), but the levels and fractions in preeclamptics (0.48 +/- 0.01 mmol/L and 64.2 +/- 1.7%) were not significantly different (P > .05) from those in normal, pregnant women. Similarly, the levels and fractions of IMg2+ in the two eclamptic patients were within the ranges of normal and preeclamptic pregnancies. When the other cations were analyzed, a highly significant elevation (P < .001) in the mean K+ level and the K+/IMg2+ ratio in the preeclamptic patients was noted. Thus, it appears that serum IMg2+ levels are maintained in preeclampsia and eclampsia, but disturbances in K homeostasis and in the interrelationships between K and IMg2+ may occur. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/7776305/Ionized_serum_magnesium_and_potassium_levels_in_pregnant_women_with_preeclampsia_and_eclampsia_ L2 - http://www.diseaseinfosearch.org/result/5920 DB - PRIME DP - Unbound Medicine ER -