Tags

Type your tag names separated by a space and hit enter

SAG-2 oral rabies vaccine.
Onderstepoort J Vet Res. 1993 Dec; 60(4):459-62.OJ

Abstract

The live modified rabies virus vaccine strain SAG-2 was selected from SADBerne in a two step process employing anti-rabies glycoprotein monoclonal antibodies. The first two nucleotides coding for the amino acid in position 333 of the rabies glycoprotein are mutated. Arginine at position 333, which is associated with rabies pathogenicity, was substituted first by lysine and then by glutamic acid. The two nucleotide differences at position 333 in SAG-2 to any of six possible arginine triplets translated into excellent genetic stability and apathogenicity for adult mice, foxes, cats and dogs. The vaccination of foxes and dogs by the oral route provided protection against a lethal challenge with rabies virus.

Authors+Show Affiliations

Virbac Laboratories, Biological Division R & D, Carros, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7777336

Citation

Schumacher, C L., et al. "SAG-2 Oral Rabies Vaccine." The Onderstepoort Journal of Veterinary Research, vol. 60, no. 4, 1993, pp. 459-62.
Schumacher CL, Coulon P, Lafay F, et al. SAG-2 oral rabies vaccine. Onderstepoort J Vet Res. 1993;60(4):459-62.
Schumacher, C. L., Coulon, P., Lafay, F., Bénéjean, J., Aubert, M. F., Barrat, J., Aubert, A., & Flamand, A. (1993). SAG-2 oral rabies vaccine. The Onderstepoort Journal of Veterinary Research, 60(4), 459-62.
Schumacher CL, et al. SAG-2 Oral Rabies Vaccine. Onderstepoort J Vet Res. 1993;60(4):459-62. PubMed PMID: 7777336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SAG-2 oral rabies vaccine. AU - Schumacher,C L, AU - Coulon,P, AU - Lafay,F, AU - Bénéjean,J, AU - Aubert,M F, AU - Barrat,J, AU - Aubert,A, AU - Flamand,A, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 459 EP - 62 JF - The Onderstepoort journal of veterinary research JO - Onderstepoort J Vet Res VL - 60 IS - 4 N2 - The live modified rabies virus vaccine strain SAG-2 was selected from SADBerne in a two step process employing anti-rabies glycoprotein monoclonal antibodies. The first two nucleotides coding for the amino acid in position 333 of the rabies glycoprotein are mutated. Arginine at position 333, which is associated with rabies pathogenicity, was substituted first by lysine and then by glutamic acid. The two nucleotide differences at position 333 in SAG-2 to any of six possible arginine triplets translated into excellent genetic stability and apathogenicity for adult mice, foxes, cats and dogs. The vaccination of foxes and dogs by the oral route provided protection against a lethal challenge with rabies virus. SN - 0030-2465 UR - https://www.unboundmedicine.com/medline/citation/7777336/SAG_2_oral_rabies_vaccine_ L2 - https://medlineplus.gov/rabies.html DB - PRIME DP - Unbound Medicine ER -