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Comparison of the effects of a range of dietary lipids upon serum and tissue lipid composition in the rat.
Int J Biochem Cell Biol 1995; 27(3):297-310IJ

Abstract

Since the type of fat consumed in the diet may play a role in the development of several disorders, it is important to ascertain the effects of different dietary fats upon parameters such as serum lipid levels and adipose deposition. The aim of this study was to determine the effects of feeding rats a range of fats with differing fatty acid compositions. Weanling male rats were fed for 10 weeks on a low fat (LF) diet or on one of five high fat diets, which contained 20% by weight of either hydrogenated coconut oil (HCO), olive oil (OO), safflower oil (SO), evening primrose oil (EPO) or menhaden (fish) oil (MO). Food intake, animal growth, tissue weights at sacrifice, serum and liver lipid concentrations and serum, heart, brain and adipose tissue fatty acid compositions were studied. The food intake of the LF-fed animals was greater than that of animals fed on the high fat diets; there were no differences in food intake between animals fed the high fat diets. The total energy intake was lower for animals fed on the HCO diet than for those fed on the LF, OO, EPO or MO diets; there were no other differences in energy intake between the groups. Animals fed the different diets had almost identical rates of weight gain up to 5 weeks; after this period of rapid growth, the increase in weight was slower in all groups but especially in the LF-fed animals. The LF-fed rats had a lower total weight gain and smaller final weights than rats fed on the high fat diets. Animals fed on the MO diet had a greater weight gain than those fed on the OO or EPO diets and their final weights were greater. The MO diet resulted in greatly increased liver weight compared with each of the other diets. The HCO, OO and EPO diets also increased liver weight compared with the LF diet. The total lipid content of the livers from rats fed the high fat diets was greater than that of those from rats fed the LF diet; the livers from animals fed the MO diet contained more lipid than those from animals fed each of the other diets. MO feeding increased the free cholesterol, cholesterol ester and triacylglycerol contents of the liver.(

ABSTRACT

TRUNCATED AT 400 WORDS)

Authors+Show Affiliations

Department of Biochemistry, University of Oxford, England.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7780834

Citation

Yaqoob, P, et al. "Comparison of the Effects of a Range of Dietary Lipids Upon Serum and Tissue Lipid Composition in the Rat." The International Journal of Biochemistry & Cell Biology, vol. 27, no. 3, 1995, pp. 297-310.
Yaqoob P, Sherrington EJ, Jeffery NM, et al. Comparison of the effects of a range of dietary lipids upon serum and tissue lipid composition in the rat. Int J Biochem Cell Biol. 1995;27(3):297-310.
Yaqoob, P., Sherrington, E. J., Jeffery, N. M., Sanderson, P., Harvey, D. J., Newsholme, E. A., & Calder, P. C. (1995). Comparison of the effects of a range of dietary lipids upon serum and tissue lipid composition in the rat. The International Journal of Biochemistry & Cell Biology, 27(3), pp. 297-310.
Yaqoob P, et al. Comparison of the Effects of a Range of Dietary Lipids Upon Serum and Tissue Lipid Composition in the Rat. Int J Biochem Cell Biol. 1995;27(3):297-310. PubMed PMID: 7780834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the effects of a range of dietary lipids upon serum and tissue lipid composition in the rat. AU - Yaqoob,P, AU - Sherrington,E J, AU - Jeffery,N M, AU - Sanderson,P, AU - Harvey,D J, AU - Newsholme,E A, AU - Calder,P C, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 297 EP - 310 JF - The international journal of biochemistry & cell biology JO - Int. J. Biochem. Cell Biol. VL - 27 IS - 3 N2 - Since the type of fat consumed in the diet may play a role in the development of several disorders, it is important to ascertain the effects of different dietary fats upon parameters such as serum lipid levels and adipose deposition. The aim of this study was to determine the effects of feeding rats a range of fats with differing fatty acid compositions. Weanling male rats were fed for 10 weeks on a low fat (LF) diet or on one of five high fat diets, which contained 20% by weight of either hydrogenated coconut oil (HCO), olive oil (OO), safflower oil (SO), evening primrose oil (EPO) or menhaden (fish) oil (MO). Food intake, animal growth, tissue weights at sacrifice, serum and liver lipid concentrations and serum, heart, brain and adipose tissue fatty acid compositions were studied. The food intake of the LF-fed animals was greater than that of animals fed on the high fat diets; there were no differences in food intake between animals fed the high fat diets. The total energy intake was lower for animals fed on the HCO diet than for those fed on the LF, OO, EPO or MO diets; there were no other differences in energy intake between the groups. Animals fed the different diets had almost identical rates of weight gain up to 5 weeks; after this period of rapid growth, the increase in weight was slower in all groups but especially in the LF-fed animals. The LF-fed rats had a lower total weight gain and smaller final weights than rats fed on the high fat diets. Animals fed on the MO diet had a greater weight gain than those fed on the OO or EPO diets and their final weights were greater. The MO diet resulted in greatly increased liver weight compared with each of the other diets. The HCO, OO and EPO diets also increased liver weight compared with the LF diet. The total lipid content of the livers from rats fed the high fat diets was greater than that of those from rats fed the LF diet; the livers from animals fed the MO diet contained more lipid than those from animals fed each of the other diets. MO feeding increased the free cholesterol, cholesterol ester and triacylglycerol contents of the liver.(ABSTRACT TRUNCATED AT 400 WORDS) SN - 1357-2725 UR - https://www.unboundmedicine.com/medline/citation/7780834/Comparison_of_the_effects_of_a_range_of_dietary_lipids_upon_serum_and_tissue_lipid_composition_in_the_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/1357-2725(94)00065-J DB - PRIME DP - Unbound Medicine ER -