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Role of nephrocalcin in inhibition of calcium oxalate crystallization and nephrolithiasis.
Miner Electrolyte Metab. 1994; 20(6):378-84.ME

Abstract

Kidney cells produce at least three proteins that slow the rate of calcium oxalate crystallization. Nephrocalcin (NC), one of the three, is an acidic glycoprotein that contains gamma-carboxyglutamic acid (GLA), and inhibits nucleation, aggregation and growth of calcium oxalate crystals. Nephrocalcin is abnormal in urine of stone-forming patients, in lacking GLA. It acts by absorbing to crystal surfaces. NC is produced by cultured renal proximal tubule cells, and by some lines of renal carcinoma cells, but its regulation is not yet characterized. Its sequence is not known, nor do we known the molecular basis for the abnormal character of NC is stone-forming patients. Compared to Tamm-Horsefall protein and uropontin, the two other inhibitors, NC is very potent, and is probably of major importance in protecting kidneys against supersaturations caused by normal water conservation.

Authors+Show Affiliations

Nephrology Section MC5100, University of Chicago, School of Medicine, IL 60637, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

7783700

Citation

Coe, F L., et al. "Role of Nephrocalcin in Inhibition of Calcium Oxalate Crystallization and Nephrolithiasis." Mineral and Electrolyte Metabolism, vol. 20, no. 6, 1994, pp. 378-84.
Coe FL, Nakagawa Y, Asplin J, et al. Role of nephrocalcin in inhibition of calcium oxalate crystallization and nephrolithiasis. Miner Electrolyte Metab. 1994;20(6):378-84.
Coe, F. L., Nakagawa, Y., Asplin, J., & Parks, J. H. (1994). Role of nephrocalcin in inhibition of calcium oxalate crystallization and nephrolithiasis. Mineral and Electrolyte Metabolism, 20(6), 378-84.
Coe FL, et al. Role of Nephrocalcin in Inhibition of Calcium Oxalate Crystallization and Nephrolithiasis. Miner Electrolyte Metab. 1994;20(6):378-84. PubMed PMID: 7783700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of nephrocalcin in inhibition of calcium oxalate crystallization and nephrolithiasis. AU - Coe,F L, AU - Nakagawa,Y, AU - Asplin,J, AU - Parks,J H, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 378 EP - 84 JF - Mineral and electrolyte metabolism JO - Miner Electrolyte Metab VL - 20 IS - 6 N2 - Kidney cells produce at least three proteins that slow the rate of calcium oxalate crystallization. Nephrocalcin (NC), one of the three, is an acidic glycoprotein that contains gamma-carboxyglutamic acid (GLA), and inhibits nucleation, aggregation and growth of calcium oxalate crystals. Nephrocalcin is abnormal in urine of stone-forming patients, in lacking GLA. It acts by absorbing to crystal surfaces. NC is produced by cultured renal proximal tubule cells, and by some lines of renal carcinoma cells, but its regulation is not yet characterized. Its sequence is not known, nor do we known the molecular basis for the abnormal character of NC is stone-forming patients. Compared to Tamm-Horsefall protein and uropontin, the two other inhibitors, NC is very potent, and is probably of major importance in protecting kidneys against supersaturations caused by normal water conservation. SN - 0378-0392 UR - https://www.unboundmedicine.com/medline/citation/7783700/Role_of_nephrocalcin_in_inhibition_of_calcium_oxalate_crystallization_and_nephrolithiasis_ L2 - https://antibodies.cancer.gov/detail/CPTC-SPP1-1 DB - PRIME DP - Unbound Medicine ER -