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Autonomic dysfunction in pathologically confirmed multiple system atrophy and idiopathic Parkinson's disease--a retrospective comparison.
Acta Neurol Scand. 1995 Feb; 91(2):98-102.AN

Abstract

INTRODUCTION

Autonomic dysfunction (AD) can be a feature of both multiple system atrophy (MSA) and idiopathic Parkinson's disease (IPD), conditions that are frequently misdiagnosed in life. Most studies on AD in MSA and IPD are based on clinical cases without pathological verification.

MATERIAL AND METHODS

We retrospectively analysed AD in 135 pathologically confirmed cases of IPD and in 33 of MSA from the UK PD Society Brain Bank.

RESULTS

MSA started at a younger age than IPD (54.4 +/- 10.7 yrs versus 60.6 +/- 10.8 yrs), and AD began earlier in the course of the illness All MSA patients had some degree of AD in life whereas AD was absent in 24% of IPD patients. Although each of five autonomic domains was affected in variable numbers of IPD patients, AD in MSA generally involved more autonomic domains than in IPD, and to a more severe degree, in particular with regard to inspiratory stridor.

CONCLUSIONS

These results indicate that the presence of autonomic disturbance alone does not distinguish between MSA and IPD in individual cases. However, the presence of severe AD, of AD preceding parkinsonism, or of inspiratory stridor, are all individually suggestive of MSA.

Authors+Show Affiliations

University Department of Clinical Neurology, Institute of Neurology, London, England.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7785431

Citation

Magalhães, M, et al. "Autonomic Dysfunction in Pathologically Confirmed Multiple System Atrophy and Idiopathic Parkinson's Disease--a Retrospective Comparison." Acta Neurologica Scandinavica, vol. 91, no. 2, 1995, pp. 98-102.
Magalhães M, Wenning GK, Daniel SE, et al. Autonomic dysfunction in pathologically confirmed multiple system atrophy and idiopathic Parkinson's disease--a retrospective comparison. Acta Neurol Scand. 1995;91(2):98-102.
Magalhães, M., Wenning, G. K., Daniel, S. E., & Quinn, N. P. (1995). Autonomic dysfunction in pathologically confirmed multiple system atrophy and idiopathic Parkinson's disease--a retrospective comparison. Acta Neurologica Scandinavica, 91(2), 98-102.
Magalhães M, et al. Autonomic Dysfunction in Pathologically Confirmed Multiple System Atrophy and Idiopathic Parkinson's Disease--a Retrospective Comparison. Acta Neurol Scand. 1995;91(2):98-102. PubMed PMID: 7785431.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autonomic dysfunction in pathologically confirmed multiple system atrophy and idiopathic Parkinson's disease--a retrospective comparison. AU - Magalhães,M, AU - Wenning,G K, AU - Daniel,S E, AU - Quinn,N P, PY - 1995/2/1/pubmed PY - 1995/2/1/medline PY - 1995/2/1/entrez SP - 98 EP - 102 JF - Acta neurologica Scandinavica JO - Acta Neurol Scand VL - 91 IS - 2 N2 - INTRODUCTION: Autonomic dysfunction (AD) can be a feature of both multiple system atrophy (MSA) and idiopathic Parkinson's disease (IPD), conditions that are frequently misdiagnosed in life. Most studies on AD in MSA and IPD are based on clinical cases without pathological verification. MATERIAL AND METHODS: We retrospectively analysed AD in 135 pathologically confirmed cases of IPD and in 33 of MSA from the UK PD Society Brain Bank. RESULTS: MSA started at a younger age than IPD (54.4 +/- 10.7 yrs versus 60.6 +/- 10.8 yrs), and AD began earlier in the course of the illness All MSA patients had some degree of AD in life whereas AD was absent in 24% of IPD patients. Although each of five autonomic domains was affected in variable numbers of IPD patients, AD in MSA generally involved more autonomic domains than in IPD, and to a more severe degree, in particular with regard to inspiratory stridor. CONCLUSIONS: These results indicate that the presence of autonomic disturbance alone does not distinguish between MSA and IPD in individual cases. However, the presence of severe AD, of AD preceding parkinsonism, or of inspiratory stridor, are all individually suggestive of MSA. SN - 0001-6314 UR - https://www.unboundmedicine.com/medline/citation/7785431/Autonomic_dysfunction_in_pathologically_confirmed_multiple_system_atrophy_and_idiopathic_Parkinson's_disease__a_retrospective_comparison_ DB - PRIME DP - Unbound Medicine ER -