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Discriminative value of biochemical markers of bone turnover in assessing the activity of Paget's disease.
J Bone Miner Res. 1995 Mar; 10(3):458-65.JB

Abstract

Clinical biochemical markers of bone turnover are usually increased in Paget's disease. However, the analysis of "new" markers, such as serum bone alkaline phosphatase (BAP), carboxy-terminal propeptide of type I procollagen (PICP), tartrate-resistant acid phosphatase (TRAP), telopeptide carboxy-terminal propeptide of type I collagen (ICTP), and urinary pyridinoline (PYR) and deoxipyridinoline (D-PYR), may improve the diagnostic efficacy and the evaluation of Paget's disease compared with conventional markers, such as serum total alkaline phosphatase (TAP) and urinary hydroxyproline (HYP). To evaluate the diagnostic accuracy and the changes of biochemical markers of bone turnover according to Paget's disease activity, we measured the levels of all these markers in three groups of pagetic patients classified according to their serum TAP activity: G-I, patients with serum TAP lower than 250 U/l (upper limit) (n = 15); G-II, patients with serum TAP between 251 and 500 U/l (n = 18); and G-III, patients with serum TAP greater than 501 U/l (n = 26). Serum TAP and BAP showed the highest diagnostic accuracy among the markers of bone formation with a sensitivity of 78% and 84%, respectively, when the specificity was 100%. Urinary PYR was the most sensitive marker of bone resorption. Also, urinary PYR showed the highest proportion of increased values in pagetic patients (73%) compared with urinary HYP (64%), urinary D-PYR (60%), serum ICTP (41%), or serum TRAP (39%). In pagetic patients with normal serum TAP activity (G-I), serum BAP concentration was increased in 60% of patients, and urinary PYR was increased in 40% of patients.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Service of Clinical Biochemistry, Hospital Clínic, University of Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

7785468

Citation

Alvarez, L, et al. "Discriminative Value of Biochemical Markers of Bone Turnover in Assessing the Activity of Paget's Disease." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 10, no. 3, 1995, pp. 458-65.
Alvarez L, Guañabens N, Peris P, et al. Discriminative value of biochemical markers of bone turnover in assessing the activity of Paget's disease. J Bone Miner Res. 1995;10(3):458-65.
Alvarez, L., Guañabens, N., Peris, P., Monegal, A., Bedini, J. L., Deulofeu, R., Martinez de Osaba, M. J., Muñoz-Gomez, J., Rivera-Fillat, F., & Ballesta, A. M. (1995). Discriminative value of biochemical markers of bone turnover in assessing the activity of Paget's disease. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 10(3), 458-65.
Alvarez L, et al. Discriminative Value of Biochemical Markers of Bone Turnover in Assessing the Activity of Paget's Disease. J Bone Miner Res. 1995;10(3):458-65. PubMed PMID: 7785468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Discriminative value of biochemical markers of bone turnover in assessing the activity of Paget's disease. AU - Alvarez,L, AU - Guañabens,N, AU - Peris,P, AU - Monegal,A, AU - Bedini,J L, AU - Deulofeu,R, AU - Martinez de Osaba,M J, AU - Muñoz-Gomez,J, AU - Rivera-Fillat,F, AU - Ballesta,A M, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 458 EP - 65 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J Bone Miner Res VL - 10 IS - 3 N2 - Clinical biochemical markers of bone turnover are usually increased in Paget's disease. However, the analysis of "new" markers, such as serum bone alkaline phosphatase (BAP), carboxy-terminal propeptide of type I procollagen (PICP), tartrate-resistant acid phosphatase (TRAP), telopeptide carboxy-terminal propeptide of type I collagen (ICTP), and urinary pyridinoline (PYR) and deoxipyridinoline (D-PYR), may improve the diagnostic efficacy and the evaluation of Paget's disease compared with conventional markers, such as serum total alkaline phosphatase (TAP) and urinary hydroxyproline (HYP). To evaluate the diagnostic accuracy and the changes of biochemical markers of bone turnover according to Paget's disease activity, we measured the levels of all these markers in three groups of pagetic patients classified according to their serum TAP activity: G-I, patients with serum TAP lower than 250 U/l (upper limit) (n = 15); G-II, patients with serum TAP between 251 and 500 U/l (n = 18); and G-III, patients with serum TAP greater than 501 U/l (n = 26). Serum TAP and BAP showed the highest diagnostic accuracy among the markers of bone formation with a sensitivity of 78% and 84%, respectively, when the specificity was 100%. Urinary PYR was the most sensitive marker of bone resorption. Also, urinary PYR showed the highest proportion of increased values in pagetic patients (73%) compared with urinary HYP (64%), urinary D-PYR (60%), serum ICTP (41%), or serum TRAP (39%). In pagetic patients with normal serum TAP activity (G-I), serum BAP concentration was increased in 60% of patients, and urinary PYR was increased in 40% of patients.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/7785468/Discriminative_value_of_biochemical_markers_of_bone_turnover_in_assessing_the_activity_of_Paget's_disease_ L2 - https://doi.org/10.1002/jbmr.5650100318 DB - PRIME DP - Unbound Medicine ER -