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Dietary fat and age-related maculopathy.
Arch Ophthalmol 1995; 113(6):743-8AO

Abstract

OBJECTIVE

To describe the relationship between type and level of fat in the diet and the prevalence of age-related maculopathy.

DESIGN

Retrospective population-based study.

SETTING AND PARTICIPANTS

Residents of Beaver Dam, Wis, between the ages of 45 and 84 years, participating in the Beaver Dam Eye Study and Nutritional Factors in Eye Disease Study.

DATA COLLECTION

Presence and severity of age-related maculopathy were determined from masked grading of fundus photographs taken from 1988 through 1990. Diets in the past (1978 through 1980) were assessed retrospectively using a food frequency questionnaire during in-person home interviews.

RESULTS

Persons with intake of saturated fat and cholesterol in the highest compared with the lowest quintile had 80% and 60% increased odds for early age-related maculopathy, respectively, after adjusting for age and intake of beer. These relationships were not influenced by adjusting for several other potential confounding variables (carotenoid intake, intake of vitamins C or E in supplements, smoking, body mass index, time spent outdoors in the summer, gender, and history of diabetes, hypertension, or cardiovascular disease). Odds ratios for late age-related maculopathy were in similar directions but were not statistically significant.

CONCLUSIONS

High intake of saturated fat and cholesterol is associated with increased risk for early age-related maculopathy in the Beaver Dam population. This supports the hypothesis that atherosclerosis or its risk factors are related to age-related maculopathy. Confirmation of this finding in other populations and in prospective studies is needed.

Authors+Show Affiliations

Department of Ophthalmology, University of Wisconsin Medical School, Madison, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7786215

Citation

Mares-Perlman, J A., et al. "Dietary Fat and Age-related Maculopathy." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 113, no. 6, 1995, pp. 743-8.
Mares-Perlman JA, Brady WE, Klein R, et al. Dietary fat and age-related maculopathy. Arch Ophthalmol. 1995;113(6):743-8.
Mares-Perlman, J. A., Brady, W. E., Klein, R., VandenLangenberg, G. M., Klein, B. E., & Palta, M. (1995). Dietary fat and age-related maculopathy. Archives of Ophthalmology (Chicago, Ill. : 1960), 113(6), pp. 743-8.
Mares-Perlman JA, et al. Dietary Fat and Age-related Maculopathy. Arch Ophthalmol. 1995;113(6):743-8. PubMed PMID: 7786215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fat and age-related maculopathy. AU - Mares-Perlman,J A, AU - Brady,W E, AU - Klein,R, AU - VandenLangenberg,G M, AU - Klein,B E, AU - Palta,M, PY - 1995/6/1/pubmed PY - 1995/6/1/medline PY - 1995/6/1/entrez SP - 743 EP - 8 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 113 IS - 6 N2 - OBJECTIVE: To describe the relationship between type and level of fat in the diet and the prevalence of age-related maculopathy. DESIGN: Retrospective population-based study. SETTING AND PARTICIPANTS: Residents of Beaver Dam, Wis, between the ages of 45 and 84 years, participating in the Beaver Dam Eye Study and Nutritional Factors in Eye Disease Study. DATA COLLECTION: Presence and severity of age-related maculopathy were determined from masked grading of fundus photographs taken from 1988 through 1990. Diets in the past (1978 through 1980) were assessed retrospectively using a food frequency questionnaire during in-person home interviews. RESULTS: Persons with intake of saturated fat and cholesterol in the highest compared with the lowest quintile had 80% and 60% increased odds for early age-related maculopathy, respectively, after adjusting for age and intake of beer. These relationships were not influenced by adjusting for several other potential confounding variables (carotenoid intake, intake of vitamins C or E in supplements, smoking, body mass index, time spent outdoors in the summer, gender, and history of diabetes, hypertension, or cardiovascular disease). Odds ratios for late age-related maculopathy were in similar directions but were not statistically significant. CONCLUSIONS: High intake of saturated fat and cholesterol is associated with increased risk for early age-related maculopathy in the Beaver Dam population. This supports the hypothesis that atherosclerosis or its risk factors are related to age-related maculopathy. Confirmation of this finding in other populations and in prospective studies is needed. SN - 0003-9950 UR - https://www.unboundmedicine.com/medline/citation/7786215/full_citation L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/vol/113/pg/743 DB - PRIME DP - Unbound Medicine ER -