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Molluscicidal saponins from Catunaregam nilotica.
Phytochemistry. 1995 May; 39(1):63-8.P

Abstract

Two new saponins were isolated from the fruits of Catunaregam nilotica Stapf, syn. Lachnosiphonium nilotica; Randia nilotica; Xeromphis nilotica. Their structures were determined mainly by spectroscopic methods as 3- O-[O-alpha-L-rhamnopyranosyl-(1-->3)-O-[O-beta-D-glucopyranosyl-(1 -->3)]- beta-D-glucopyranosyl]oleanolic acid and 28-O-beta-D- glucopyranosyl-3-O-[O-alpha-L-rhamnopyranosyl-(1-->3)-O[O-beta-D- glucopyranosyl]-beta-D-glycopyranosyl]oleanolate. The monodesmosidic saponin is a potent molluscicide against the schistosomiasis transmitting snail Biomphalaria glabrata with a LC50 value of 3 ppm. In addition two known saponins, 3-O-[2', 3'-di-O-(beta-D-glucopyranosyl)-beta-D- glucopyranosyl]oleanolic acid and 3-O-[O-beta-D-glucopyranosyl(1-->3)- beta-D-glucopyranosyl]oleanolic acid, were identified and their molluscicidal activity determined, the LC50 values being 26 and 3 ppm, respectively. Initial molluscicidal screening of the crude water and ethanol extracts revealed 100% snail mortality at concentrations of 100 and 50 ppm, respectively. The haemolytic activity of the molluscicidal saponins was determined as well and the HC50 values towards bovine erythrocytes found to be 3 ppm for the new saponin, and 16 and 2 ppm, respectively, for the two known saponins.

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Authors+Show Affiliations

Lemmich E
Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Copenhagen.
Cornett C
No affiliation info available
Furu P
No affiliation info available
Jørstian CL
No affiliation info available
Knudsen AD
No affiliation info available
Olsen CE
No affiliation info available
Salih A
No affiliation info available
Thilborg ST
No affiliation info available

MeSH

AnimalsCarbohydrate SequenceMagnetic Resonance SpectroscopyMolecular Sequence DataMolluscacidesOleanolic AcidSaponinsTrees

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7786492

Citation

Lemmich, E, et al. "Molluscicidal Saponins From Catunaregam Nilotica." Phytochemistry, vol. 39, no. 1, 1995, pp. 63-8.
Lemmich E, Cornett C, Furu P, et al. Molluscicidal saponins from Catunaregam nilotica. Phytochemistry. 1995;39(1):63-8.
Lemmich, E., Cornett, C., Furu, P., Jørstian, C. L., Knudsen, A. D., Olsen, C. E., Salih, A., & Thilborg, S. T. (1995). Molluscicidal saponins from Catunaregam nilotica. Phytochemistry, 39(1), 63-8.
Lemmich E, et al. Molluscicidal Saponins From Catunaregam Nilotica. Phytochemistry. 1995;39(1):63-8. PubMed PMID: 7786492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molluscicidal saponins from Catunaregam nilotica. AU - Lemmich,E, AU - Cornett,C, AU - Furu,P, AU - Jørstian,C L, AU - Knudsen,A D, AU - Olsen,C E, AU - Salih,A, AU - Thilborg,S T, PY - 1995/5/1/pubmed PY - 1995/5/1/medline PY - 1995/5/1/entrez SP - 63 EP - 8 JF - Phytochemistry JO - Phytochemistry VL - 39 IS - 1 N2 - Two new saponins were isolated from the fruits of Catunaregam nilotica Stapf, syn. Lachnosiphonium nilotica; Randia nilotica; Xeromphis nilotica. Their structures were determined mainly by spectroscopic methods as 3- O-[O-alpha-L-rhamnopyranosyl-(1-->3)-O-[O-beta-D-glucopyranosyl-(1 -->3)]- beta-D-glucopyranosyl]oleanolic acid and 28-O-beta-D- glucopyranosyl-3-O-[O-alpha-L-rhamnopyranosyl-(1-->3)-O[O-beta-D- glucopyranosyl]-beta-D-glycopyranosyl]oleanolate. The monodesmosidic saponin is a potent molluscicide against the schistosomiasis transmitting snail Biomphalaria glabrata with a LC50 value of 3 ppm. In addition two known saponins, 3-O-[2', 3'-di-O-(beta-D-glucopyranosyl)-beta-D- glucopyranosyl]oleanolic acid and 3-O-[O-beta-D-glucopyranosyl(1-->3)- beta-D-glucopyranosyl]oleanolic acid, were identified and their molluscicidal activity determined, the LC50 values being 26 and 3 ppm, respectively. Initial molluscicidal screening of the crude water and ethanol extracts revealed 100% snail mortality at concentrations of 100 and 50 ppm, respectively. The haemolytic activity of the molluscicidal saponins was determined as well and the HC50 values towards bovine erythrocytes found to be 3 ppm for the new saponin, and 16 and 2 ppm, respectively, for the two known saponins. SN - 0031-9422 UR - https://www.unboundmedicine.com/medline/citation/7786492/Molluscicidal_saponins_from_Catunaregam_nilotica_ L2 - https://linkinghub.elsevier.com/retrieve/pii/003194229400866R DB - PRIME DP - Unbound Medicine ER -